山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (1): 81-87.doi: 10.6040/j.issn.1673-3770.1.2018.026

• 论著 • 上一篇    下一篇

大气污染物对于变应性鼻炎症状严重度的影响

李丽莎1,2,关凯1,2,王子熹1,2,崔乐1,2   

  1. 1.中国医学科学院 北京协和医学院 北京协和医院变态(过敏)反应科, 北京 100730;
    2.过敏性疾病精准诊疗研究北京市重点实验室, 北京 100730
  • 出版日期:2019-01-20 发布日期:2019-01-28
  • 作者简介:李丽莎. E-mail:doctorlilisha@163.com
  • 基金资助:
    北京自然科学基金面上项目(7172179)

The effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen

LI Lisha1,2, GUAN Kai1,2, WANG Zixi1,2, CUI Le1,2   

  1. Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing 100730, China
  • Online:2019-01-20 Published:2019-01-28

HTML

PDF (PC)

457

摘要： 目的 以柏树花粉过敏所致变应性鼻炎(AR)为研究对象,探讨大气污染物对变应性鼻炎严重程度的影响。 方法 招募柏树花粉AR患者81例,2016~2018年间每年在柏树花粉授粉期间记录患者每日鼻结膜炎症状评分,同时从中国气象局气象数据中心获取气象数据,从国家环境监测站数据库获取大气污染数据,应用多元线性回归分析探讨大气污染物浓度对于AR日均症状评分的影响。 结果 在控制柏树花粉浓度与气象因素影响的前提下,AR患者日均症状评分与大气中SO2浓度有统计学意义的正相关,多元线性回归分析显示其相关系数=0.038, 95% CI (0.004, 0.072), P=0.027;而大气中PM2.5, PM10, CO, NO2, O3指标的浓度与AR日均症状评分均无统计学意义的关联。 结论 柏树花粉过敏性AR患者的症状严重度受到大气污染物的影响,SO2浓度越高,AR症状越重。

关键词: 变应性鼻炎, 症状评分, 大气污染, 二氧化硫, 柏树花粉

Abstract: Objective The association between allergic disorder prevalence and monitored air pollutants has been supported by past research evidence. The aim of this study was to evaluate the effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen. Methods Eighty-one patients with allergic rhinitis(AR)caused by cypress pollen were recruited. From 2016 to 2018, patients recorded daily average symptom scores during the cypress pollen season. Meanwhile, the meteorological data were acquired from the Meteorological Data Center of the China Meteorological Administration, and air pollutant data were acquired from the database of the China National Environmental Monitoring Center. The effects of air pollutant concentrations on the daily average symptom scores of patients with AR were then analyzed using the multiple linear regression model. Results A statistical correlation between the concentration of SO2 and daily average AR symptom score was found in this study(regression coefficient=0.038, 95% CI［0.004, 0.072］, P=0.027)after adjusting for the effects of cypress pollen concentration and meteorological variables, while the associations between average symptom score and other air pollutants including PM2.5, PM10, CO, NO2, and O3 were insignificant. Conclusion The severity of AR caused by cypress pollen is correlated with air pollutant concentrations, and SO2 might significantly increase the severity of AR symptoms.

Key words: Allergic rhinitis, Symptom score, Air pollution, Sulfur dioxide, Cypress pollens

中图分类号: 

  • R765
[1] Suárez-Varela MM, Gallardo-Juan A, García-Marcos L, et al. The impact of atmospheric pollutants on the prevalence of atopic eczema in 6-7-year-old schoolchildren in Spain; ISAAC Phase III[J]. Iran J Allergy Asthma Immunol, 2013, 12(3):220-227.
[2] Miyamoto T, Takafuji S. Environment and Allergy[M] // Miyamoto T, Takafuji S. eds. New Trends in Allergy III. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991:459-466. doi:10.1007/978-3-642-46717-2_61
[3] Halonen JI, Lanki T, Yli-Tuomi T, et al. Urban air pollution, and asthma and COPD hospital emergency room visits[J]. Thorax, 2008, 63(7):635-641. doi:10.1136/thx.2007.091371.
[4] Akinbami LJ, Lynch CD, Parker JD, et al. The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001-2004[J]. Environ Res, 2010, 110(3):294-301. doi:10.1016/j.envres.2010.01.001.
[5] Ngoc LTN, Park D, Lee Y, et al. Systematic review and meta-analysis of human skin diseases due to particulate matter[J]. Int J Environ Res Public Health, 2017, 14(12):E1458. doi:10.3390/ijerph14121458.
[6] Canonica GW, Bousquet J, Mullol J, et al. A survey of the burden of allergic rhinitis in Europe[J]. Allergy, 2007, 62(Suppl 85):17-25. doi:10.1111/j.1398-9995.2007.01549.x.
[7] Wang KY, Chau TT. An association between air pollution and daily outpatient visits for respiratory disease in a heavy industry area[J]. PLoS One, 2013, 8(10):e75220. doi:10.1371/journal.pone.0075220.
[8] Lindgren A, Stroh E, Nihlén U, et al. Traffic exposure associated with allergic asthma and allergic rhinitis in adults. A cross-sectional study in southern Sweden[J]. Int J Health Geogr, 2009, 8:25. doi:10.1186/1476-072X-8-25.
[9] Nordling E, Berglind N, Melén E, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies[J]. Epidemiology, 2008, 19(3):401-408. doi:10.1097/EDE.0b013e31816a1ce3.
[10] Ackaert C, Kofler S, Horejs-Hoeck J, et al. The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101[J]. PLoS One, 2014, 9(8):e104520. doi:10.1371/journal.pone.0104520.
[11] Zou QY, Shen Y, Ke X, et al. Exposure to air pollution and risk of prevalence of childhood allergic rhinitis: a meta-analysis[J]. Int J Pediatr Otorhinolaryngol, 2018, 112:82-90. doi:10.1016/j.ijporl.2018.06.039.
[12] Zhang FY, Wang WY, Lv J, et al. Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China[J]. Sci Total Environ, 2011, 409(13):2486-2492. doi:10.1016/j.scitotenv.2011.04.007.
[13] Liu MM, Wang D, Zhao Y, et al. Effects of outdoor and indoor air pollution on respiratory health of Chinese children from 50 kindergartens[J]. J Epidemiol, 2013, 23(4):280-287.
[14] Hwang BF, Jaakkola JJ, Lee YL, et al. Relation between air pollution and allergic rhinitis in Taiwanese schoolchildren[J]. Respir Res, 2006, 7:23. doi:10.1186/1465-9921-7-23.
[15] Meng Z. Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide is a systemic oxidative damage agent[J]. Inhal Toxicol,2003,15(2):181-195. doi:10.1080/08958370304476.
[16] Bateson TF, Schwartz J. Children's response to air pollutants[J]. J Toxicol Environ Health Part A, 2008, 71(3):238-243. doi:10.1080/15287390701598234.
[17] Li XJ, Huang LQ, Wang N, et al. Sulfur dioxide exposure enhances Th2 inflammatory responses via activating STAT6 pathway in asthmatic mice[J]. Toxicol Lett, 2018, 285:43-50. doi:10.1016/j.toxlet.2017.12.020.
[18] Cai C, Xu J, Zhang M, et al. Prior SO2 exposure promotes airway inflammation and subepithelial fibrosis following repeated ovalbumin challenge[J]. Clin Exp Allergy, 2008, 38(10):1680-1687. doi:10.1111/j.1365-2222.2008.03053.x.
[19] 王晨霞, 袁芳. 空气污染对变应性鼻炎发病的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(18):1455-1458. doi:10.13201/j.issn.1001-1781.2017.18.019. WANG Chenxia, YUAN Fang. The influence of air pollution on the pathogenesis of allergic rhinitis[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2017, 31(18):1455-1458. doi:10.13201/j.issn.1001-1781.2017.18.019.
[20] Behrendt H, Alessandrini F, Buters J, et al. Environmental pollution and allergy: historical aspects[J]. Chem Immunol Allergy, 2014, 100:268-277. doi:10.1159/000359918.
[21] Lu C, Deng QH, Ou CY, et al. Effects of ambient air pollution on allergic rhinitis among preschool children in Changsha, China[J]. Chin Sci Bull, 2013, 58(34):4252-4258. doi:10.1007/s11434-013-5725-2.
[22] Tecer LH, Alagha O, Karaca F, et al. Particulate matter(PM(2.5), PM(10-2.5), and PM(10))and children's hospital admissions for asthma and respiratory diseases: a bidirectional case-crossover study[J]. J Toxicol Environ Health Part A, 2008, 71(8):512-520. doi:10.1080/15287390801907459.
[23] 何珊, 牟喆, 彭丽, 等. 气象环境因素对儿童变应性鼻炎自觉症状影响的研究[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(16):1458-1462,1466. doi:10.13201/j.issn.1001-1781.2015.16.012. HE Shan, MOU Zhe, PENG Li, et al. Effects of meteorological and environmental factors on subjective symptoms of allergic rhinitis in children[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2015, 29(16):1458-1462,1466. doi:10.13201/j.issn.1001-1781.2015.16.012.
[24] Gent JF, Belanger K, Triche EW, et al. Association of pediatric asthma severity with exposure to common household dust allergens[J]. Environ Res, 2009, 109(6):768-774. doi:10.1016/j.envres.2009.04.010.
[25] Do DC, Zhao Y, Gao P. Cockroach allergen exposure and risk of asthma[J]. Allergy, 2016, 71(4):463-474. doi:10.1111/all.12827.
[26] 李挚, 何海娟, 孙国强, 等. 北京市区与过敏相关的气传花粉[J]. 基础医学与临床, 2015, 35(6):734-738. doi:10.3390/ijerph14030226. LI Zhi, HE Haijuan, SUN Guoqiang, et al. Allergy-related airborne pollen in urban area of Beijing[J]. Basic Medical Sciences and Clinics, 2015, 35(6):734-738.doi:10.3390/ijerph14030226.
[27] Teng B, Zhang XL, Yi CH, et al. The association between ambient air pollution and allergic rhinitis: further epidemiological evidence from Changchun, northeastern China[J]. Int J Environ Res Public Health, 2017, 14(3):E226. doi:10.3390/ijerph14030226.
[28] Baroody FM, Assanasen P, Chung J, et al. Hot, humid air partially inhibits the nasal response to allergen provocation[J]. Arch Otolaryngol Head Neck Surg, 2000, 126(6):749-754.
[1] 秦雅楠,王琳,姜彦,闫舒,陈敏,于龙刚,李娜. 2008~2017年青岛地区变应性鼻炎常见吸入性变应原分布[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 67-72.
[2] 杜经纬,冯俊,马鹏,李志勇,李红光. 鼻腔冲洗联合鼻用糖皮质激素对AR患者FeNO、肺功能及生活质量的影响[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 124-127.
[3] 洪冬冬,刘元献,邹练强,翁镌凌,邓文娴. 变应性鼻炎患者粉尘螨皮肤点刺试验阳性764例结果分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 119-123.
[4] 齐岩,刘俊其,彭舒娅,罗凯,张名霞,王振霖. 鼻内镜下选择性翼管神经切断术对伴有变应性鼻炎的慢性鼻窦炎的疗效观察[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 109-113.
[5] 郭胤仕,卢慧. Ⅱ型固有淋巴细胞在变应性鼻炎发病机制中的作用[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 9-12.
[6] 曹成,许昱. 变应性鼻炎患者舌下免疫治疗的临床依从性192例分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 114-118.
[7] 邱前辉,高俊潇. 特异性免疫治疗对过敏性鼻炎和哮喘的同步控制和远期疗效[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 33-37.
[8] 金兴,胡大宇,朱丽,邓芙蓉,刘俊秀. PM2.5与变应性鼻炎患者上气道阻力的相关性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 77-80.
[9] 洪海裕, 许光福, 杨烁伟,苏荣飞,黄伊厘,池梦诗,王玮豪,杨钦泰. 探究广东地区变应性鼻炎合并支气管哮喘的危险因素[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 94-98.
[10] 卢汉桂,林歆胜,姚丹勉,魏永新,李创伟. 变应性鼻炎大鼠IL-35的表达及对辅助性T细胞免疫调节的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 66-70.
[11] 王坛,武珂,李连庆,宫丽丽. 皮下免疫治疗注射后出现全身不良反应的伴发因素及处理[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 71-74.
[12] 浦洪波,杜晓东. 无锡地区2 000例变应性鼻炎变应原检测结果分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 105-107.
[13] 陈鸣,俞雪飞. 浅谈伴有变应性鼻炎的慢性鼻窦炎的治疗[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 18-22.
[14] 吴湘萍. 患者管理方式对变应性鼻炎舌下含服粉尘螨滴剂疗效的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 68-72.
[15] 李松,王宗贵,杨景朴,张竹萍. 鼻内镜下翼管神经切断术进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(1): 72-76.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 杨长亮,黄治物,姚行齐,诸勇,孙艺 . 正常气骨导听性脑干反应及其应用[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 9 -13 .
[2] 万俐佳,鲁海涛,姜义道,刘 辉,李 琴,佘腊枝 . 改良腭咽成形术治疗阻塞性睡眠呼吸暂停综合征41例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 204 -205 .
[3] 刘 艳,刘新义,王金平,李大健 . 后鼓室解剖结构测量观察及临床意义[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 218 -221 .
[4] 于青青 综述,王跃建 审校 . 硬质耳内镜的临床应用进展[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 222 -224 .
[5] 刘强和,罗香林,耿宛平,陈 晨,雷 迅,刘芳贤,邓 明 . 快速老化小鼠的听功能和耳蜗螺旋神经元的增龄性变化[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 215 -217 .
[6] 杨淑娟,袁 英,刘付星,秦海平 . 美宝湿润烧伤膏联合蛋膜贴补治疗外伤性鼓膜穿孔40例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 227 -227 .
[7] 林峰,梁勇,卢永田,万丽霞 . 鼻内翻性乳头状瘤临床分型和术式选择[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 231 -233 .
[8] 白广平,李 俊,董 频 . 鼻内镜下手术治疗慢性鼻窦炎、鼻息肉180例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 242 -243 .
[9] 赵 敏,王守森,甄泽年,陈贤明,王茂鑫 . 鼻内镜联合显微镜行蝶窦及经蝶鞍区微创手术[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 244 -245 .
[10] 楼正才,楼放毅,金忠海 . 咽异感症405例病因分析[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 271 -275 .
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发