山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (1): 86-91.doi: 10.6040/j.issn.1673-3770.0.2020.157

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降钙素原在甲状腺髓样癌荷瘤鼠血清中的含量及相关性研究

曾博,田兴德   

  1. 长江大学附属第一医院 耳鼻咽喉头颈外科, 湖北 荆州 434000
  • 发布日期:2021-02-01
  • 通讯作者: 田兴德. E-mail:jztian0716@sina.com

Relationship between serum procalcitonin level of tumor-bearing mice and medullary thyroid carcinoma

ZENG Bo, TIAN Xingde   

  1. Department of Otolaryngology & Head and Neck Surgery, the First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei,  China
  • Published:2021-02-01

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摘要： 目的 探讨甲状腺髓样癌血清中降钙素原含量与作为MTC的肿瘤标志物的血清降钙素含量之间的关系。 方法 建立MTC荷瘤小鼠模型,检测小鼠血清中PCT及CT的含量,测量MTC瘤体的瘤质量和体积,分析PCT及CT与MTC肿瘤之间的相关性。 结果 MTC荷瘤小鼠血清中PCT及CT的含量与瘤质量呈显著正相关;MTC荷瘤鼠血清中的PCT与CT含量呈显著正相关。 结论 MTC荷瘤小鼠血清中PCT的含量与CT的含量具有一致性,PCT可以作为MTC的肿瘤标志物。

关键词: 甲状腺髓样癌, 降钙素原, 降钙素, 血清, 含量, 小鼠

Abstract: Objective To study the relationship between serum procalcitonin(PCT)and calcitonin(CT)levels in medullary thyroid carcinoma(MTC). Methods We evaluated the serum PCT and CT levels, tumor weight and volume, and bodyweight using MTC mice models to ascertain the relationship between serum PCT and CT and tumors. Results Serum PCT and CT in the group A mice were significantly and positively correlated with tumor weight; serum PCT and CT were also positively correlated. Conclusions This experiment demonstrates that serum PCT may be used as a tumor marker for MTC, in addition to serum CT, which has demonstrated utility for the diagnosis of MTC.

Key words: Medullary thyroid carcinoma, Procalcitonin, Calcitonin, Serum, Level, Mice

中图分类号: 

  • R762
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