国内近10年干眼相关研究——基于Citespace的可视化分析

doi:10.6040/j.issn.1673-3770.0.2020.271

摘要/Abstract

摘要： 目的为了解国内干眼研究现状,以Citespace绘制的知识图谱为基础概述干眼近十年研究概况,并尝试识别此领域研究热点及热点演变趋势。方法以中国知网、Web of science核心数据集(SCI-EXPANDED)收录的近十年(2010~2020年6月)文献记录为研究对象,利用Citespace软件绘制研究机构的网络合作关系图谱;以关键词为节点,对关键词进行共现分析、Burst分析、聚类分析及Timeline分析,绘制并解读各图谱。结果合作高产机构并具有一定影响力的机构以中山大学、复旦大学、南昌大学第一附属医院眼科为代表。现研究热点相对集中于:(1)干眼的病因病机与干眼和睑板腺功能、眼表、泪膜及其他疾病(炎症、糖尿病、青光眼、白内障等)间的联系;(2)干眼症状及治疗方式,密蒙花相关药物、玻璃酸钠滴眼液与传统针刺、中药熏蒸等方式疗效及相关机制的临床试验与动物实验研究;(3)儿童患干眼的相关影响因素及其治疗等研究。预测:(1)发生机制与预防,干眼与白内障、白内障术后、睑板腺功能障碍之间的联系;(2)诊断与评估:眼表综合分析仪在干眼症中的应用;(3)治疗:探索干眼的多种治疗方式的疗效与相应机制,包括中医特色治疗方式,如针灸及具有现代特点的治疗方式,如强脉冲光(IPL)、新药利福舒特滴眼液等在内的新药等,以上主题可能持续为此领域未来一段时间内的研究热点,建议通过中西医结合的方式治疗干眼以进一步提高干眼症的临床疗效。结论研究明确了干眼研究领域较有影响力机构,概括现研究热点前沿并预测了热点演变趋势,以期为日后的相关研究提供指导。

关键词: 干眼, Citespace, 计量学分析, 综述, 可视化分析

Abstract: Objective We used the CitesSpace-based knowledge mapping to evaluate the research on dry eyes and identify the hotspots and foci and their evolutionary trend. Methods We used a collection of dry eye studies spanning nearly ten years(2010-June 2020). The institute was the node for the study on network cooperation and relationship mapping. Using keywords for the node, we performed the keyword co-occurrence analysis, Burst analysis, clustering analysis, and time evolution analysis. Subsequently, the mapping results were interpreted. Results The cooperative high-yield institutions were the Departments of Ophthalmology of Sun Yat-sen University, Fudan University, and the First Affiliated Hospital of Nanchang University. The following are current research hotspots for the etiology and pathogenesis of dry eye, dry eye and meibomian gland function, ocular surface, and tear film, among others:(1)Relationship between diseases such as inflammatory conditions, diabetes, glaucoma, and cataract;(2)Dry eye symptoms and treatment methods: the clinical efficacy and mechanisms of medicinal flowers, sodium hyaluronate eye drops, traditional acupuncture, and fumigation of traditional Chinese medicine, Research using animal experiments;(3)Research on related factors and treatment of dry eye in children. Prediction of dry eye:(1)Mechanism and prevention: the relationship between dry eye and cataract, cataract surgery, and meibomian gland dysfunction;(2)Diagnosis and evaluation: the application of ocular surface comprehensive analyzer in dry eye;(3)Treatment: exploring the curative effect and corresponding mechanisms of various treatment methods of dry eye, including traditional Chinese medicine treatment methods, such as acupuncture, and modern treatment methods such as intense pulsed light(IPL)and new drugs such as rifaxute eye drops. These may continue to be research hotspots in this field. Conclusions This study ascertains the institutions that are influential in the research field of dry eye, summarizes the current research hotspots, and predicts the evolution of these hotspots to guide future research.

Key words: Dry eyes, Citespace, Metrological analysis, Review, Visual analysis

中图分类号:

R779.6

肖西立,聂渝晓,陈婕. 国内近10年干眼相关研究——基于Citespace的可视化分析[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 86-97.

XIAO Xili, NIE Yuxiao, CHEN Jie. Visual analysis of domestic studies on dry eye syndrome in the past ten years using Citespace[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 86-97.

参考文献

[1] The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop(2007)[J]. Ocular Surf, 2007, 5(2): 75-92. doi:10.1016/s1542-0124(12)70081-2.
[2] Messmer EM. Novel current and future therapy options for treatment of dry eye disease[J]. Ophthalmologe, 2018, 115(2): 100-106. doi:10.1007/s00347-017-0608-6.
[3] 亚洲干眼协会中国分会, 海峡两岸医药卫生交流协会眼科学专业委员会眼表与泪液病学组, 中国医师协会眼科医师分会眼表与干眼学组. 中国干眼专家共识:定义和分类(2020年)[J]. 中华眼科杂志, 2020, 56(6): 418-422. doi:10.3760/cma.j.cn112142-20200316-00190.
[4] Shine WE, McCulley JP. Keratoconjunctivitis sicca associated with meibomian secretion polar lipid abnormality[J]. Arch Ophthalmol, 1998, 116(7): 849-852. doi:10.1001/archopht.116.7.849.
[5] Li J, Li Y, Zhang M, et al. Silencing of Rac1 expression via RNA interference inhibits retinal neovascularization in rats[J]. Mol Vis, 2012, 18: 1354-1360. doi: 10.1016/j.cbi.2012.04.005.
[6] 中华医学会眼科学分会角膜病学组. 干眼临床诊疗专家共识(2013年)[J]. 中华眼科杂志, 2013, 49(1): 73-75. doi:10.3760/cma.j.issn.0412-4081.2013.01.020.
[7] 朱丹, 年朝霞, 刘洋, 等. 眼科门诊患者干眼症流行病学调查分析[J]. 海峡预防医学杂志, 2018, 24(5): 33-35. doi: CNKI:SUN:HXYF.0.2018-05-014.
[8] 陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能[J]. 科学学研究, 2015, 33(2): 242-253. doi:10.16192/j.cnki.1003-2053.2015.02.009. CHEN Yue, CHEN Chaomei, LIU Zeyuan, et al. The methodology function of Cite Space mapping knowledge domains[J]. Studies in Science of Science, 2015, 33(2): 242-253. doi:10.16192/j.cnki.1003-2053.2015.02.009.
[9] 陈悦, 刘则渊. 悄然兴起的科学知识图谱[J]. 科学学研究, 2005, 23(2): 149-154. doi:10.16192/j.cnki.1003-2053.2005.02.002. CHEN Yue, LIU Zeyuan. The rise of mapping knowledge domain[J]. Studies in Science of Science, 2005, 23(2): 149-154. doi:10.16192/j.cnki.1003-2053.2005.02.002.
[10] 秦长江, 侯汉清. 知识图谱: 信息管理与知识管理的新领域[J]. 大学图书馆学报, 2009, 27(1): 30-37, 96. doi:10.3969/j.issn.1002-1027.2009.01.007. QIN Changjiang, HOU Hanqing. Mapping knowledge domain: a new field of information management and knowledge management[J]. Journal of Academic Libraries, 2009, 27(1): 30-37, 96. doi:10.3969/j.issn.1002-1027.2009.01.007.
[11] 孙继飞, 邵霖霖, 褚文丽, 等. 针灸治疗干眼的作用机制及疗效研究进展[J]. 中国中医眼科杂志, 2020, 30(4): 281-284. doi:10.13444/j.cnki.zgzyykzz.2020.04.013. SUN Jifei, SHAO Linlin, CHU Wenli, et al. Research progress on mechanism and curative effect of acupuncture on dry eye[J]. China Journal of Chinese Ophthalmology, 2020, 30(4): 281-284. doi:10.13444/j.cnki.zgzyykzz.2020.04.013.
[12] 周尚昆. 养血通络润目汤治疗睑板腺功能障碍性干眼的临床观察[J]. 中国中医眼科杂志, 2019, 29(4): 289-292. doi:10.13444/j.cnki.zgzyykzz.2019.04.008. ZHOU Shangkun. Clinical observation on the treatment of dry eyes due to meibomian gland dysfunction with Yangxue Tongluo Runmu decoction[J]. China Journal of Chinese Ophthalmology, 2019, 29(4): 289-292. doi:10.13444/j.cnki.zgzyykzz.2019.04.008.
[13] 陈水龄, 褚文丽, 张丛青, 等. 亢泽峰辨治干眼的思路[J]. 中华中医药杂志, 2019, 34(7): 3097-3100. doi: CNKI:SUN:BXYY.0.2019-07-074. CHEN Shuiling, CHU Wenli, ZHANG Congqing, et al. KANG Ze-feng's syndrome differentiation thoughts in treating dry eye[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2019, 34(7): 3097-3100. doi: CNKI:SUN:BXYY.0.2019-07-074.
[14] 丁宁, 高卫萍. 类风湿性关节炎与干眼的相关性研究[J]. 西部中医药, 2018, 31(3): 1-5. doi: CNKI:SUN:GSZY.0.2018-03-001. DING Ning, GAO Weiping. Study on the correlation of rheumatoid arthritis with xeroma[J]. Western Journal of Traditional Chinese Medicine, 2018, 31(3): 1-5. doi: CNKI:SUN:GSZY.0.2018-03-001.
[15] 孙利, 胡天明, 李长生. 滋阴润目颗粒治疗干眼症的临床疗效观察[J]. 现代中医药, 2020, 40(2): 90-93. doi:10.13424/j.cnki.mtcm.2020.02.025.
[16] 孙文秀, 何慧琴. 温胆汤加减治疗湿热内蕴型干眼经验[J]. 环球中医药, 2019, 12(6): 923-925. doi:10.3969/j.issn.1674-1749.2019.06.029.
[17] 王娇娇. 针刺调节水液缺乏性干眼的胆碱能信号转导通路的实验研究[D]. 南京: 南京中医药大学, 2019.
[18] 陈立浩, 时健, 刘倩宏, 等. 菊花总黄酮对去势所致干眼雄兔泪腺组织中AR、AR mRNA、Bax mRNA及形态学的影响[J]. 湖南中医药大学学报, 2020, 40(4): 406-411. doi:10.3969/j.issn.1674-070X.2020.04.005. CHEN Lihao, SHI Jian, LIU Qianhong, et al. Effects of total flavonoids from Chrysanthemum on AR, AR mRNA, bax mRNA and morphology in lacrimal gland of castrated dry eye male rabbits[J]. Journal of Traditional Chinese Medicine University of Hunan, 2020, 40(4): 406-411. doi:10.3969/j.issn.1674-070X.2020.04.005.
[19] 李玲, 李点, 袁娉, 等. 基于p38MAPK信号通路研究养阴润目丸治疗干眼兔的作用机制[J]. 湖南中医药大学学报, 2019, 39(10): 1189-1194. doi:10.3969/j.issn.1674-070X.2019.10.004. LI Ling, LI Dian, YUAN Ping, et al. Study on the mechanism of Yangyin runmu pills in the treatment of rabbit with dry eye based on p38 MAPK signaling pathway[J]. Journal of Traditional Chinese Medicine University of Hunan, 2019, 39(10): 1189-1194. doi:10.3969/j.issn.1674-070X.2019.10.004.
[20] 蒋鹏飞, 彭俊, 彭清华. 浅析从阳虚角度论治干眼[J]. 湖南中医药大学学报, 2018, 38(4): 410-412. doi:10.3969/j.issn.1674-070X.2018.04.011. JIANG Pengfei, PENG Jun, PENG Qinghua. Analysis on treatment of dry eye from Yang deficiency[J]. Journal of Traditional Chinese Medicine University of Hunan, 2018, 38(4): 410-412. doi:10.3969/j.issn.1674-070X.2018.04.011.
[21] 彭清华, 姚小磊, 彭俊, 等. 密蒙花提取物滴眼剂对实验性干眼症鼠泪腺组织细胞凋亡的影响[J]. 国际眼科杂志, 2010, 10(1): 40-43. doi:10.3969/j.issn.1672-5123.2010.01.011. PENG Qinghua, YAO Xiaolei, PENG Jun, et al. Effects of extract of Buddleja officinalis eye drops on lacrimal gland cells apoptosis of castrated rabbits with dry eye[J]. International Journal of Ophthalmology, 2010, 10(1): 40-43. doi:10.3969/j.issn.1672-5123.2010.01.011.
[22] Tsubota K, Yokoi N, Shimazaki J, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the Asia dry eye society[J]. Ocular Surf, 2017, 15(1): 65-76. doi:10.1016/j.jtos.2016.09.003.
[23] 赵建保. C iteS pac e可视化流程与分析范式研究[J]. 知识经济, 2014(16): 105-107. doi:10.3969/j.issn.1007-3825.2014.16.072.
[24] 李洁. 中药喷雾治疗干眼症30例[J]. 上海中医药杂志, 2003, 37(4): 38-39. doi:10.16305/j.1007-1334.2003.04.016. LI Jie. Chinese medical spray for xerophthalmia in 30 cases[J]. Shanghai Journal of Traditional Chinese Medicine, 2003, 37(4): 38-39. doi:10.16305/j.1007-1334.2003.04.016.
[25] Linna TU, Vesaluoma MH, Pérez-Santonja JJ, et al. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves[J]. Invest Ophthalmol Vis Sci, 2000, 41(2): 393-397.
[26] Albietz JM, Lenton LM, McLennan SG. Effect of laser in situ keratomileusis for hyperopia on tear film and ocular surface[J]. J Refract Surg, 2002, 18(2): 113-123. doi:10.3928/1081-597x-20020301-02.
[27] 信兆亭, 杨莎莎, 吴欣怡. 干眼影响因素的临床分析[J]. 山东大学耳鼻喉眼学报, 2011, 25(4): 83-86. doi:10.6040/j.issn.1673-3770.0.2011.04. XIN Zhaoting, YANG Shasha, WU Xinyi. Clinical analysis of risk factors of dry eye[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2011, 25(4): 83-86. doi:10.6040/j.issn.1673-3770.0.2011.04.
[28] Gipson IK, Spurr-Michaud SJ, Senchyna M, et al. Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye[J]. Cornea, 2011, 30(12): 1346-1352. doi:10.1097/ico.0b013e31820d852a.
[29] Mostafa S, Seamon V, Azzarolo AM. Influence of sex hormones and genetic predisposition in Sjögren's syndrome: a new clue to the immunopathogenesis of dry eye disease[J]. Exp Eye Res, 2012, 96(1): 88-97. doi:10.1016/j.exer.2011.12.016.
[30] Lurati AR. Menopause and dry eye syndrome[J]. Nurs Womens Health, 2019, 23(1): 71-78. doi:10.1016/j.nwh.2018.11.001.
[31] 孙子雯, 崔洪玮, 孙喜灵, 等. 干眼病的病因、发病机制及治疗进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(2): 159-166. doi:10.6040/j.issn.1673-3770.0.2018.411. SUN Ziwen, CUI Hongwei, SUN Xiling, et al. SUN Ziwen1, CUI Hongwei2, SUN XilingEtiology, pathogenesis, and management of dry eye[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 159-166. doi:10.6040/j.issn.1673-3770.0.2018.411.
[32] Foulks GN, Forstot SL, Donshik PC, et al. Clinical guidelines for management of dry eye associated with Sjögren disease[J]. Ocul Surf, 2015, 13(2): 118-132. doi:10.1016/j.jtos.2014.12.001.
[33] ??塁im??塂ek C, Do(ˇoverg)ru M, Kojima T, et al. Current management and treatment of dry eye disease[J]. Turk J Ophthalmol, 2018, 48(6): 309-313. doi:10.4274/tjo.69320.
[34] 涂雪峰. 重组牛碱性成纤维细胞生长因子联合玻璃酸钠治疗干眼症的疗效分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(6): 84-87. doi:10.6040/j.issn.1673-3770.0.2017.509. TU Xuefeng. Clinical effect of combination therapy of sodium hyaluronate and recombinant bovine basic fibroblast growth factor on dry eye after phacoemulsification[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 84-87. doi:10.6040/j.issn.1673-3770.0.2017.509.
[35] 张菊, 吴欣怡. 0.1%环孢素滴眼液联合玻璃酸钠滴眼液治疗眼干燥症[J]. 山东大学耳鼻喉眼学报, 2015(1): 49-51. doi:10.6040/j.issn.1673-3770.0.2014.342. ZHANG Ju, WU Xinyi. Effects of 0.1% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2015(1): 49-51. doi:10.6040/j.issn.1673-3770.0.2014.342.
[36] Higuchi A, Ueno R, Shimmura S, et al. Albumin rescues ocular epithelial cells from cell death in dry eye[J]. Curr Eye Res, 2007, 32(2): 83-88. doi:10.1080/02713680601147690.
[37] Kojima T, Ishida R, Dogru M, et al. The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study[J]. Am J Ophthalmol, 2005, 139(2): 242-246. doi:10.1016/j.ajo.2004.08.040.
[38] Marsh P, Pflugfelder SC. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome[J]. Ophthalmology, 1999, 106(4): 811-816. doi:10.1016/S0161-6420(99)90171-9.
[39] Calonge M. The treatment of dry eye[J]. Surv Ophthalmol, 2001, 45: S227-S239. doi:10.1016/S0039-6257(00)00205-8.
[40] Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop(2007)[J]. Ocul Surf, 2007, 5(2): 163-178. doi:10.1016/s1542-0124(12)70085-x.
[41] 郭胜, 杨君, 芦佳娜. 绝经后干眼症与性激素的关系[J]. 临床医药实践, 2008, 17(7): 502-504. doi:10.3969/j.issn.1671-8631.2008.07.010. GUO Sheng, YANG Jun, LU Jiana. The relation between postmenopause dry eye and sex hormone[J]. Proceeding of Clinical Medicine, 2008, 17(7): 502-504. doi:10.3969/j.issn.1671-8631.2008.07.010.
[42] Messmer EM. The pathophysiology, diagnosis, and treatment of dry eye disease[J]. Deutsches Aerzteblatt Online, 2015, 112: 71-82. doi:10.3238/arztebl.2015.0071.
[43] 肖秀林. 激素替代疗法在更年期妇女干眼症的应用[J]. 中国实用眼科杂志, 2006, 24(3): 329-330. doi:10.3760/cma.j.issn.1006-4443.2006.03.031.
[44] Chan TCY, Chow SSW, Wan KHN, et al. Update on the association between dry eye disease and meibomian gland dysfunction[J]. Hong Kong Med J, 2019, 25(1): 38-47. doi:10.12809/hkmj187331.
[45] Yin L, Zhang MX, He TG, et al. The expression of miRNA-146a-5p and its mechanism of treating dry eye syndrome[J]. J Clin Lab Anal, 2020, 1-17. doi: 10.21203/rs.3.rs-25725/v2.
[46] 武蓉, 张栩, 沈念慈. 干眼综合征的中西医结合治疗[J]. 山东医大基础医学院学报, 2000, 14(5): 260-261. doi:10.3969/j.issn.1673-3770.2000.05.002. WU Rong, ZHANG Xu, SHEN Nianci. Treatment of dry eye syndrome combined with traditional Chinese medicine[J]. Journal of Preclinical Medicine College of Shandong Medical University, 2000, 14(5): 260-261. doi:10.3969/j.issn.1673-3770.2000.05.002.
[47] 杨梓超, 王育良. 眼干燥症的病因、发病机制及中西医结合治疗进展[J]. 山东大学耳鼻喉眼学报, 2015(2): 91-93. doi:10.6040/j.issn.1673-3770.0.2014.394. YANG Zichao, WANG Yuliang. Etiology, mechanism of dye eye and advancement of traditional Chinese medicine in combination with western medicine for it[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2015(2): 91-93. doi:10.6040/j.issn.1673-3770.0.2014.394.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed