透明质酸在慢性鼻窦炎中的研究进展

doi:10.6040/j.issn.1673-3770.0.2021.226

摘要/Abstract

摘要： 慢性鼻窦炎(CRS)是耳鼻咽喉头颈外科的常见疾病,其病因学及病理生理机制复杂,可影响5%~12%的人群。无论药物还是手术治疗,相关方案均在不断完善及改进。透明质酸因其独特的生物学特性,在CRS患者中通过多种途径及方式,以达到治疗的作用和目的,在临床上应用广泛。阐述透明质酸在CRS中可能的作用机制及应用以达到治疗的方式,并探索透明质酸未来可能的治疗模式,为CRS的临床治疗提供新思路。

关键词: 透明质酸, 慢性鼻窦炎, 鼻内镜鼻窦手术, 细菌生物膜

Abstract: In otolaryngology-head and neck surgery, chronic sinusitis is a common disease that affects 5%-12% of the population with a complex etiology and pathophysiological mechanism. Drug and surgical treatment for this disease are constantly being improved. Hyaluronic acid(HA), through various pathways, is widely used in clinical practice in patients with chronic rhinosinusitis(CRS). This paper aims to explain the possible mechanism of action of hyaluronic acid in CRS and its current application in achieving the treatment mode, as well as explore the possible future treatment mode of HA to improve the clinical treatment of CRS.

Key words: Hyaluronic acid, Chronic rhinosinusitis, Endoscopic sinus surgery, Bacterial biofilm

中图分类号:

R765

曹轩,肖旭平,李云秋. 透明质酸在慢性鼻窦炎中的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 104-109.

CAO Xuan,XIAO Xuping, LI Yunqiu. Advances in the application of hyaluronic acid in chronic sinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 104-109.

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