咽喉反流与复发性呼吸道乳头状瘤病的关系及其机制探讨

doi:10.6040/j.issn.1673-3770.0.2023.010

摘要/Abstract

摘要： 咽喉反流(laryngopharyngeal reflux, LPR)作为一种独立风险因素,在咽喉部肿瘤的发生中有着不可忽视的作用。复发性呼吸道乳头状瘤病(recurrent respiratory papillomatosis, RRP)是一种复发率极高的疾病,多发生在喉部,虽为良性肿瘤但也有癌变可能。目前的主要治疗方式仍为手术治疗,干扰素、西多福韦等药物的应用可作为辅助治疗手段。有研究发现,在RRP病程中采取抗反流治疗对其发展有一定的控制作用,且有多项研究表明咽喉反流可能是导致RRP的危险因素。论文回顾国内外相关文献,介绍了目前国内外LPR与RRP的相关研究进展,并讨论LPR与RRP可能存在的关系及LPR在RRP发生、发展及恶性转变中的可能作用,以期为下一步深入探索LPR与RRP之间的具体机制提供理论依据,并为临床医生对RRP的诊治提供新的思路。

关键词: 咽喉反流, 复发性呼吸道乳头状瘤病, 人乳头瘤病毒, 胃蛋白酶

Abstract: Laryngopharyngeal reflux(LPR)has a non-negligible role in the development of laryngeal tumors as an independent risk factor. Recurrent respiratory papillomatosis(RRP)is a disease with a very high recurrence rate, mostly in the larynx, which is benign but can be cancerous. The main treatment remains surgery, and the application of drugs, such as interferon and cidofovir, can be used as adjuvant therapy. Some studies have found that anti-reflux treatment also controls its development, and several studies have shown that LPR may be a risk factor for recurrent respiratory papillomatosis. We review the relevant literature at home and abroad that introduce the current research progress in LPR and RRP and discuss the possible relationship between LPR and RRP and the possible role of LPR in the occurrence, development, and malignant transformation of RRP to provide a theoretical basis for the next in-depth exploration of the specific mechanism and provide clinicians with new ideas for the diagnosis and treatment of RRP.

Key words: Laryngopharyngeal reflux, Recurrent respiratory papillomatosis, Human papillomavirus, Pepsin

中图分类号:

R766.5

赵佳宁,崔元馨,王丹,赵明. 咽喉反流与复发性呼吸道乳头状瘤病的关系及其机制探讨[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 39-45.

ZHAO Jianing, CUI Yuanxin, WANG Dan, ZHAO Ming. Exploration of the relationship between laryngopharyngeal reflux and recurrent respiratory papilloma and its mechanism[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 39-45.

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