山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (4): 45-50.doi: 10.6040/j.issn.1673-3770.0.2020.481

• • 上一篇    下一篇

头颈部转移性透明细胞癌5例并文献复习

刘盼1,2,王川1,2,赵泽祺1,2,吴梅1,3,徐继峰1,2,李巍2,张伟强2,刘稳2   

  1. 1. 徐州医科大学 研究生学院, 江苏 徐州 221004;
    2. 徐州医科大学附属医院 耳鼻咽喉头颈外科, 江苏 徐州 221002;
    3. 徐州医科大学附属医院 病理科, 江苏 徐州 221002
  • 发布日期:2021-08-05
  • 通讯作者: 刘稳. E-mail:liuwen1972@163.com

Five cases of metastatic clear cell carcinoma of the head and neck: a case report and literature review

LIU Pan1,2, WANG Chuan1,2, ZHAO Zeqi1,2, WU Mei1,3, XU Jifeng1,2, LI Wei2, ZHANG Weiqiang2, LIU Wen2   

  1. 1. Graduate School of Xuzhou Medical University, Xuzhou 221004, Jiangsu, China;
    2. Department of Otolaryngology & Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China;
    3. Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China
  • Published:2021-08-05

PDF (PC)

283

摘要： 目的 探讨泌尿系统透明细胞癌转移至头颈的部位和治疗方法。 方法 总结我院2011年至2018年收治的具有完整临床资料的5例头颈部转移性透明细胞癌,分析原发疾病、原发病治疗方法、转移时间、转移部位、转移灶治疗方法、预后等临床资料。 结果 5例透明细胞癌原发灶位于肾脏4例、膀胱1例,原发灶均行根治性手术。转移时间为原发灶术后1~10年,转移至上颌窦1例、额窦额骨1例、额窦筛窦1例、室带1例、额部皮下1例。4例转移灶手术后均复发并死于全身转移,仅1例皮下转移患者存活。 结论 透明细胞癌转移至头颈部较为罕见,根治性手术切除是治疗头颈部转移性透明细胞癌的主要方法,患者多死于全身多发转移。

关键词: 头颈部, 透明细胞癌, 转移, 治疗, 预后

Abstract: Objective To explore the location and treatment of the metastasis of clear cell carcinoma of the urinary system to the head and neck. Methods Five cases of metastatic clear cell carcinoma of the head and neck admitted to our hospital during 2011-2018 were summarized. The clinical data and treatment method of the primary disease, time of metastasis, site of metastasis, treatment approach for the metastasis, and prognosis were recorded. Results Five cases of clear cell carcinoma involved primary lesions in the kidney(4 cases)and bladder(1 case), all of which underwent radical surgery. The metastases developed 1-10 years after the surgery of the primary lesions, including 1 case involving the maxillary sinus, 1 case involving the frontal sinus and bone, 1 case involving the frontal and ethmoid sinus, 1 case involving the ventricular band, and 1 case involving the frontal subcutaneous area. All four patients had recurrence and died of systemic metastasis, and only 1 patient with subcutaneous metastasis survived. Conclusion Metastasis of clear cell carcinoma to the head and neck is rare. Radical surgical resection is the main method for treating metastatic clear cell carcinoma of the head and neck. Most patients die due to multiple metastases throughout the body.

Key words: Head and neck, Clear cell carcinoma, Metastasis, Treatment, Prognosis

中图分类号: 

  • R739.62
[1] 王强, 沈毅, 孙坚. 唾液腺透明细胞癌的诊断与治疗[J]. 中国口腔颌面外科杂志, 2008, 6(4): 266-269. WANG Qiang, SHEN Yi, SUN Jian. Diagnosis and treatment of clear cell carcinoma of salivary gland[J]. China J Oral Maxillofac Surg, 2008, 6(4): 266-269.
[2] Aslıer M, Ecevit MC. Metastatic renal cell carcinoma of the nasal septum: a case report[J]. Turk Arch Otorhinolaryngol, 2018, 56(1): 51-53. doi:10.5152/tao.2018.2826.
[3] 陈孝平, 汪建平. 外科学[M]. 8版. 北京: 人民卫生出版社, 2013.
[4] Lee SM, Kim YM, Kim BM. Epistaxis as the first manifestation of silent renal cell carcinoma: a case report with relevant literature review[J]. Iran J Radiol, 2016, 13(1): e31208. doi:10.5812/iranjradiol.31208.
[5] 蔡葶, 刘稳, 倪道凤, 等. 肾透明细胞癌鼻窦转移2例[J]. 临床耳鼻咽喉头颈外科杂志, 2012,26(2): 87-88. doi:10.13201/j.issn.1001-1781.2012.02.002.
[6] 张剑伟, 张其昌, 庄汉, 等. 上颌窦内肾透明细胞癌转移1例报道[J]. 山东大学耳鼻喉眼学报, 2014(6): 96-97. doi:10.6040/j.issn.1673-3770.0.2014.175. ZHANG Jianwei, ZHANG Qichang, ZHUANG Han, et al. Renal clear cell carcinoma transferred to the maxillary sinus in 1 case[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2014(6): 96-97. doi:10.6040/j.issn.1673-3770.0.2014.175.
[7] Serra A, Caltabiano R, Giorlandino A, et al. Nasal metastasis as the first manifestation of a metachronous bilateral renal cell carcinoma[J]. Pathologica, 2017, 109(4): 421-425.
[8] 陆飞彩, 仝悦, 神平, 等. 头面部转移性透明细胞癌四例[J]. 中华耳鼻咽喉头颈外科杂志, 2017, 52(11): 855-856. doi:10.3760/cma.j.issn.1673-0860.2017.11.013. LU Feicai, TONG Yue, SHEN Ping, et al. Clear cell carcinoma of the head and face: a study of four cases[J]. Chin J Otorhinolaryngol Head Neck Surg, 2017, 52(11): 855-856. doi:10.3760/cma.j.issn.1673-0860.2017.11.013.
[9] Kovaăi c M, Krvavica A, Rudi c. Renal cell carcinoma metastasis to the sinonasal cavity: case report[J]. Acta Clin Croat, 2015, 54(2): 223-226.
[10] Allen A, Michals E, Karo A, et al. Renal cell carcinoma presenting as epistaxis from a nasal cavity metastasis[J]. Radiol Case Rep, 2019, 14(1): 116-120. doi:10.1016/j.radcr.2018.10.009.
[11] Ralli M, Altissimi G, Turchetta R, et al. Metastatic renal cell carcinoma presenting as a paranasal sinus mass: the importance of differential diagnosis[J]. Case Rep Otolaryngol, 2017, 2017:9242374. doi:10.1155/2017/9242374.
[12] Bastier PL, Dunion D, de Bonnecaze G, et al. Renal cell carcinoma metastatic to the sinonasal cavity: a review and report of 8 cases[J]. Ear Nose Throat J, 2018, 97(9): E6-E12. doi:10.1177/014556131809700902.
[13] 高天喜,李娜,李桔林,等.气囊导尿管在鼻腔鼻窦肿瘤切除术后术腔填塞中的应用[J]. 山东大学耳鼻喉眼学报,2021, 35(1): 11-15. doi: 10.6040/j.issn.1673-3770.0.2020.075. GAO Tian Xi, LI Na, LI Julin, et al. Application of air sac urinary catheter in nasal packing after endoscopic nasal surgery with a resection of sinonasal tumor[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 11-15. doi: 10.6040/j.issn.1673-3770.0.2020.075.
[14] Sahraoui S, Belaabidia B, Acharki A, et al. Carcinome à cellules claires du larynx: revue de la littérature, à propos d’un cas[J]. Cancer/Radiothérapie, 2001, 5(2): 155-158. doi:10.1016/S1278-3218(00)00015-9.
[15] Testa D, Galli V, de Rosa G, et al. Clinical and prognostic aspects of laryngeal clear cell carcinoma[J]. J Laryngol Otol, 2005, 119(12): 991-994. doi:10.1258/002221505775010715.
[16] Nayak DR, Balakrishnan R, Rao RV, et al. Clear cell carcinoma of the larynx: a case report[J]. Int J Pediatr Otorhinolaryngol, 2001, 57(2): 149-153. doi:10.1016/s0165-5876(00)00422-5.
[17] Demir L, Erten C, Somali I, et al. Metastases of renal cell carcinoma to the larynx and thyroid: Two case reports on metastasis developing years after nephrectomy[J]. J De L&apos, 2012, 6(5): E209-E212. doi:10.5489/cuaj.11255.
[18] Maiya S, Namiki S, Kudo T, et al. Isolated metastasis of renal cell carcinoma to the larynx: a case report[J]. Nihon Hinyokika Gakkai Zasshi Jpn J Urol, 2018, 109(3): 137-139. doi:10.5980/jpnjurol.109.137.
[19] Rossini M, Bolzoni A, Piazza C, et al. Renal cell carcinoma metastatic to the larynx[J]. Otolaryngol Head Neck Surg, 2004, 131(6): 1029-1030. doi:10.1016/j.otohns.2004.03.019.
[20] Nicolai P, Puxeddu R, Cappiello J, et al. Metastatic neoplasms to the larynx: report of three cases[J]. Laryngoscope, 1996, 106(7): 851-855. doi:10.1097/00005537-199607000-00013.
[21] Ndounga E, Peko JF, Mbon JBN. Clear cell kidney carcinoma revealed by cutaneous and sinus metastases: about a case and literature review[J]. Pan Afr Med J, 2018, 31: 66. doi:10.11604/pamj.2018.31.66.16721.
[22] Cui PF, Cong XF, Yin JX, et al. Metastases to the nose from clear cell renal cell carcinoma: a case report[J]. Medicine(Baltimore), 2019, 98(4): e14012. doi:10.1097/MD.0000000000014012.
[23] Adeniran AJ, Tamboli P. Clear cell adenocarcinoma of the urinary bladder: a short review[J]. Arch Pathol Lab Med, 2009, 133(6): 987-991. doi:10.1043/1543-2165-133.6.987.
[24] Moradi M, Shojaei S, Kaseb K, et al. Primary clear cell carcinoma of urinary bladder: a case report[J]. Urol Case Rep, 2018, 16: 41-43. doi:10.1016/j.eucr.2017.10.008.
[25] Venyo AK. Primary clear cell carcinoma of the urinary bladder[J]. Int Sch Res Notices, 2014: 593826. doi:10.1155/2014/593826.
[26] 姚琦, 郭时英, 顾苏宁. 膀胱透明细胞癌皮肤转移一例报告[J]. 中华泌尿外科杂志, 2003, 24(6): 379. doi:10.3760/j: issn: 1000-6702.2003.06.040.
[27] Peng XL, Sun PY, Yue ZZ, et al. Nephrogenic clear cell carcinoma of nasal cavity: a case report[J]. J Clin Otorhinolaryngol Head Neck Surg, 2019, 33(8): 773-774. doi:10.13201/j.issn.1001-1781.2019.08.023.
[28] McNichols DW, Segura JW, DeWeerd JH. Renal cell carcinoma: long-term survival and late recurrence[J]. J Urol, 1981, 126(1): 17-23. doi:10.1016/s0022-5347(17)54359-1.
[29] 张速勤, 王顺林, 王素敏. 原发于肾脏的鼻窦转移性透明细胞癌一例[J]. 中华耳鼻咽喉头颈外科杂志, 2005, 40(7): 551. doi:10.3760/j.issn: 1673-0860.2005.07.025. ZHANG Suqin, WANG Shunlin, WANG Sumin. One case of metastatic clear cell carcinoma from kidney to maxilla[J]. Chin J Otorhinolaryngol Head Neck Surg, 2005, 40(7): 551. doi:10.3760/j.issn: 1673-0860.2005.07.025.
[30] 张凯, 朱刚. 2020版EAU肾细胞癌诊疗指南更新解读之二[J]. 中华泌尿外科杂志, 2020, 41(8): 578-580. doi:10.3760/cma.j.cn112330-20200730-00019. ZHANG Kai, ZHU Gang. The update interpretation of 2020 EAU renal cell carcinoma guideline(Part Ⅱ)[J]. Chin J Urol, 2020, 41(8): 578-580. doi:10.3760/cma.j.cn112330-20200730-00019.
[1] 陈东彦,钱晔,魏东敏,李文明,夏同良,雷大鹏,潘新良. 高频超声诊断下咽鳞癌淋巴结转移的临床研究[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 18-23.
[2] 张钰曲毅. 眼弓形体病的发病机制及防治研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 70-76.
[3] 宋晴 宋西成. 安罗替尼联合治疗在肿瘤治疗中的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 106-112.
[4] 张可人, 雷春燕, 张美霞. 眼睑松弛综合征伴阻塞性睡眠呼吸暂停1例[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 125-128.
[5] 姜超,周炫辰,韩杰,岳志勇. IVc期下咽癌特征分析及列线图预后模型构建[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 49-54.
[6] 王媚 李志海. 喉癌干细胞:克服多药耐药性的潜在治疗靶点[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 120-128.
[7] 熊攀辉,沈暘,杨玉成. 基于表型和内在型的慢性鼻窦炎诊治进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 15-19.
[8] 王欢,胡俐,余洪猛. 慢性鼻窦炎相关嗅觉功能障碍研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 43-49.
[9] 谷钰,万鑫,肖自安. 中性粒细胞和嗜酸性粒细胞在慢性鼻窦炎中的相互影响及临床治疗思考[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 56-63.
[10] 曾宪廷,王广科,孙占伟,武天义,李世超,王卫卫. 伴咽喉反流的难治性鼻窦炎术后应用质子泵抑制剂的疗效观察[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 189-194.
[11] 刘勇,袁存立,曹慧,郑成彩,晁方, 许风雷. CHD1L通过EMT促进喉鳞状细胞癌细胞的增殖、侵袭和转移[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 32-39.
[12] 程瑶,张震,杨吉,冯成敏,邓启成,张西,赵锐,朱鑫,吴俊志,刘海,邓世山. CIP2A在下咽癌中的表达及临床意义[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 40-44.
[13] 张陶然,王薇,李明铭,黄映湘. IVR治疗mCNV患者黄斑中心凹下脉络膜厚度分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 68-71.
[14] 狄宇，李莹. 干眼炎症反应机制及抗炎治疗的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 144-150.
[15] 庞冲,边赛男,张冰,尹旭,陆颖霞,叶鹏飞,王湛,赵晶,高彦,关凯. 儿童过敏性鼻炎粉尘螨特异性舌下免疫治疗短期疗效评估[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 70-74.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张晗,黄一飞 . 抗角膜移植排斥的研究进展[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 84 -87 .
[2] 牛善利,柴茂文,李振秀 . 鼻内镜下鼻甲成形术治疗慢性肥厚性鼻炎60例[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 16 -18 .
[3] 孟庆国,卢永田,范献良 . 杀伤细胞免疫球蛋白样受体基因多态性与鼻咽癌的关联性[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 196 -199 .
[4] 马玉起,孔祥春 . 先天性双侧下唇窦道1例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 199 -199 .
[5] 万俐佳,鲁海涛,姜义道,刘 辉,李 琴,佘腊枝 . 改良腭咽成形术治疗阻塞性睡眠呼吸暂停综合征41例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 204 -205 .
[6] 于青青 ,王跃建 . 硬质耳内镜的临床应用进展[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 222 -224 .
[7] 吉晓滨,邓家德,臧林泉,王 磊,谢 军 . 豚鼠变应性鼻炎模型血清组胺的测定[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 228 -230 .
[8] 向登,卢永田,孙焕吉 . 鼻内镜下修补脑脊液鼻漏19例并文献复习[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 234 -236 .
[9] 邱恩惠,李志春,方文旭 . 嗅觉障碍的中西医治疗[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 253 -257 .
[10] 殷国华,钟 笑 . 激光减容术治疗舌扁桃体肥大的远期疗效[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 280 -282 .
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发