miRNA-29b参与上皮间质转化相关信号通路调控的研究进展

doi:10.6040/j.issn.1673-3770.0.2021.096

摘要/Abstract

摘要： 上皮间质转化(EMT)是上皮细胞转化为间质细胞的生物学过程,它赋予细胞转移和入侵的能力,与器官纤维化和肿瘤发生发展密切相关。miRNA-29b是一类与EMT过程密切相关的非编码小RNA,直接或间接调控TGF-β/Smad、PI3K/AKT、Wnt/β-catenin等多条信号通路,参与Ⅱ型和Ⅲ型EMT的发展过程,进而延缓器官纤维化进程,调控肿瘤的侵袭转移。针对miRNA-29b的靶向治疗,有望为临床诊断、治疗器官纤维化和肿瘤侵袭转移提供新视角。本文就miRNA-29b通过多条EMT相关信号通路调控器官纤维化和肿瘤侵袭转移过程的研究现状进行综述。

关键词: miRNA-29b, 上皮间质转化, 器官纤维化, 肿瘤侵袭转移, 信号通路

Abstract: Epithelial-mesenchymal transition(EMT)is a biological process of epithelial cells transforming into mesenchymal cells, conferring the ability of cell metastasis and invasion. This process is closely related to the progression of organ fibrosis and tumors. MiRNA-29b is a small noncoding RNA closely related to the EMT process. By modulating TGF-β/Smad, PI3K/AKT, Wnt/β-catenin, and other signaling pathways, miRNA-29b mediates the development of type II and type III EMT, and then delays the process of organ fibrosis, regulates the invasion and metastasis of tumors. The targeted therapy of miRNA-29b is expected to provide a new perspective for the clinical diagnosis and treatment of organ fibrosis and tumor invasion and metastasis. The research status of miRNA-29b regulating the process of organ fibrosis and tumor invasion and metastasis through various EMT-related signaling pathways was reviewed in this study.

Key words: MiRNA-29b, Epithelial-mesenchymal transition, Organ fibrosis, Tumor invasion and metastasis, Signaling pathway

中图分类号:

R762

王俊鑫,孙岩. miRNA-29b参与上皮间质转化相关信号通路调控的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 132-137.

WANG Junxin,SUN Yan. Research progress of miRNA-29b involved in EMT-related signaling pathway regulation[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 132-137.

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