NLRP3炎症小体在慢性鼻窦炎和变应性鼻炎中的研究进展

doi:10.6040/j.issn.1673-3770.0.2021.584

摘要/Abstract

摘要： 慢性鼻窦炎(CRS)和变应性鼻炎(AR)作为上气道常见的炎症性疾病,其发生发展机制与炎症小体Nod样受体(NLRs)过度激活相关。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)作为NLRs家族中最受关注的炎症小体,近年来在CRS和AR中的报道也越来越多。本综述既往文献,阐述NLPR3炎症小体在CRS和AR的发病机制、病情进展和疾病治疗等方面所起的作用,为临床工作中探索治疗靶点提供借鉴。

关键词: 慢性鼻窦炎, 变应性鼻炎, NLRP3炎症小体, Nod样受体

Abstract: Chronic rhinosinusitis(CRS)and allergic rhinitis(AR)are common upper airway inflammatory diseases. CRS and AR pathogenesis may be related to the overactivation of inflammasomes containing nucleotide-binding oligomerization domain-like receptor family(NLRs). NLR protein 3(NLRP3)is the most clinically important inflammasome in the NLR family. The reported frequency of NLRP3 has increased in recent years. This review summarizes the influence of NLPR3 on CRS and AR from three aspects: pathogenesis, disease progression, and disease treatment. Our goal is to provide a deeper understanding of the occurrence and development of these diseases and provide references for exploring various therapeutic targets.

Key words: Chronic rhinosinusitis, Allergic rhinitis, NLRP3 inflammasome, Nod-like receptors

中图分类号:

R765.4+1

刘一潼,周穗子,邱前辉. NLRP3炎症小体在慢性鼻窦炎和变应性鼻炎中的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 142-146.

LIU Yitong, ZHOU Suizi,QIU Qianhui. Research progress on NLRP3 inflammasome in chronic rhinosinusitis and allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 142-146.

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