探讨血清胆红素水平对急性会厌炎患者预后的影响

doi:10.6040/j.issn.1673-3770.0.2024.120

摘要/Abstract

摘要： 目的探讨急性会厌炎患者的血清胆红素水平变化及其对急性会厌炎预后的影响。方法采用单中心回顾性病例对照设计,纳入急性会厌炎患者105例、声带小结患者52例进行对照研究。收集患者一般临床资料、住院时长、胆红素水平以及炎症指标。对两组之间胆红素水平差异进行比较。通过相关性分析以及多元线性回归模型评估年龄、胆红素以及炎症指标与急性会厌炎患者住院时长之间的关联,及进一步分析胆红素与炎症指标之间相关性。结果入院时急性会厌炎患者与对照组相比,胆红素水平升高,且差异有统计学意义(P<0.001)。急性会厌炎患者出院前与入院时相比,胆红素降低(P<0.001)。相关性分析结果显示患者住院时长与入院时胆红素水平呈负相关(P=0.030),而与年龄、C反应蛋白、白细胞计数呈正相关(P<0.05)。多元线性回归模型显示,患者入院时胆红素是住院时长的独立影响因素(P=0.003)。患者入院时胆红素水平与全身炎症指标白细胞计数、C反应蛋白、中性粒细胞绝对值以及淋巴细胞绝对值之间未发现线性相关。结论急性会厌炎患者血清胆红素水平升高,胆红素可作为急性会厌炎患者潜在的风险评估指标。

关键词: 急性会厌炎, 胆红素, 声带小结, C反应蛋白, 白细胞, 中性粒细胞, 淋巴细胞

Abstract: Objective To investigate the serum bilirubin levels in patients with acute epiglottitis and their impact on the prognosis of the disease. Methods This single-center retrospective case-control study included 105 patients diagnosed with acute epiglottitis and 52 patients with vocal cord nodules as the control group. General clinical data, hospitalization duration, bilirubin levels, and inflammatory markers were collected. Differences in bilirubin levels between the two groups were compared. Correlation analysis and multiple linear regression models were used to assess the associations between age, bilirubin levels, inflammatory markers, and the duration of hospital stay in patients with acute epiglottitis, and to further analyze the correlation between bilirubin and inflammatory markers. Results Upon admission, patients with acute epiglottitis had significantly higher bilirubin levels compared to the control group(P<0.001). Bilirubin levels decreased before discharge compared to at admission(P<0.001). Correlation analysis showed that the duration of hospital stay was negatively correlated with bilirubin levels at admission(P=0.030), and positively correlated with age, C-reactive protein, and white blood cell count(P<0.05). Multiple linear regression models indicated that bilirubin levels at admission were an independent factor influencing the duration of hospital stay(P=0.003). No linear correlation was found between admission bilirubin levels and systemic inflammatory markers such as white blood cell count, C-reactive protein, absolute neutrophil count, and absolute lymphocyte count(P>0.05). Conclusion Serum bilirubin levels are elevated in patients with acute epiglottitis, and bilirubin may serve as a potential risk assessment indicator for these patients.

Key words: Acute Epiglottitis, Bilirubin, Vocal Cord Nodule, C-reactive Protein, Leukocyte, Neu-trophil, Lymphocyte

中图分类号:

R767.5

申博珺,刘素茹,李春燕,苏开明. 探讨血清胆红素水平对急性会厌炎患者预后的影响[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 26-31.

SHEN Bojun, LIU Suru, LI Chunyan, SU Kaiming. Investigating the impact of serum bilirubin levels on the prognosis of patients with acute epiglottitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 26-31.

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