山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (2): 122-127.doi: 10.6040/j.issn.1673-3770.0.2022.516

• 综述 • 上一篇    下一篇

IL-29和TLR4在嗜酸性粒细胞浸润鼻息肉中的表达及临床意义

晏慧娟,肖旭平,钟宇   

  1. 湖南师范大学附属第一医院/湖南省人民医院 耳鼻咽喉头颈外科, 湖南 长沙 410005
  • 出版日期:2024-03-20 发布日期:2024-03-29
  • 通讯作者: 钟宇. E-mail:4914816@qq.com

Expression and clinical significance of IL-29 and TLR4 in eosinophil infiltrated nasal polyps

YAN Huijuan, XIAO Xuping, ZHONG Yu   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Hunan Normal University / Hunan provincial People's Hospital, Changsha 410005, Hunan, China
  • Online:2024-03-20 Published:2024-03-29

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摘要： 鼻息肉是鼻腔及鼻窦黏膜上皮组织的慢性炎症性疾病,是耳鼻咽喉科的常见病之一。鼻息肉的发生与上皮屏障功能障碍、接触过敏原或病原体以及免疫功能失调有关,是炎症和纤维蛋白沉积的结果。尽管鼻内镜手术已较成熟,仍有部分鼻息肉难治疗且复发率高,研究发现超过50%慢性鼻窦炎伴鼻息肉患者可出现复发。白细胞介素-29(interleukin-29,IL-29)是新发现的Ⅲ型干扰素成员。它通过与其受体复合物结合介导信号转导并激活下游信号通路,从而诱导炎症成分的产生。Toll样受体4(Toll-like receptor 4,TLR4)是Toll样受体家族的成员,参与先天免疫,并通过识别脂多糖或细菌内毒素介导炎症反应。研究表明,TLR4在鼻息肉组织中的表达明显升高。IL-29和TLR4在炎症反应的调控中发挥重要作用,但两者与嗜酸性粒细胞浸润鼻息肉的相关性目前尚不明确。探究发现与嗜酸性粒细胞浸润鼻息肉相关的临床指标,能为鼻息肉的诊治提供新的思路。

关键词: 嗜酸性粒细胞, 鼻息肉, 白细胞介素-29, Toll样受体4

Abstract: Nasal polyp is a chronic inflammatory disease of the nasal cavity and the nasal sinus mucosal epithelium. It is a common condition in otorhinolaryngology. Nasal polyp result from inflammation and fibrin deposition and are related to epithelial barrier dysfunction. Although endoscopic sinus surgery is relatively mature, some nasal polyps are difficult to treat and the condition has a high recurrence rate. Previous studies reported a 50% recurrence in patients with. Interleukin-29(IL-29), a newly discovered member of type Ⅲ interferon, mediates signal transduction by binding to its receptor complex, activates downstream signalling pathways, and induces the generation of inflammatory components. Toll-like receptor 4(TLR4), a member of the Toll-like receptor family, is involved in innate immunity and mediates inflammatory responses by recognizing lipopolysaccharide or bacterial endotoxins. Studies have shown that the expression of TLR4 in patients with nasal polyps is significantly increased. Although IL-29 and TLR4 are important in regulating inflammatory responses, their relationship and their correlation with eosinophil infiltration in patients with nasal polyps are unclear. An exploration of the clinical indicators related to eosinophil infiltration in nasal polyps may provide new ideas for the diagnosis and treatment of nasal polyps.

Key words: Eosinophil, Nasal polyp, Interleukin-29, Toll-like receptor 4

中图分类号: 

  • R765.25
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