山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (4): 153-159.doi: 10.6040/j.issn.1673-3770.0.2022.192

• 综述 • 上一篇    

2型固有淋巴细胞在慢性鼻窦炎中的作用及调节机制研究进展

崔宁,王云梦,杨景朴   

  1. 吉林大学第二医院 耳鼻咽喉头颈外科, 吉林 长春 130041;
  • 发布日期:2023-07-27
  • 通讯作者: 杨景朴. E-mail:jingpuyangent@163.com
  • 基金资助:
    吉林省科技厅项目(20200201517JC)

Research progress on the role and regulatory mechanism of group 2 innate lymphoid cells in chronic rhinosinusitis

CUI Ning, WANG Yunmeng, YANG Jingpu   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Second Hospital of Jilin University, Changchun 130041, Jilin, China
  • Published:2023-07-27

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摘要： 慢性鼻窦炎是一种发生于鼻窦黏膜的慢性炎症疾病,主要表现为鼻塞、流涕等鼻部症状,其次是头面部胀痛、嗅觉减退或丧失,病程不少于12星期,常合并哮喘及慢性阻塞性肺疾病等呼吸道疾病。作为一种多因素病因的炎症性疾病,涉及免疫系统和上皮屏障,受微生物组群、环境和遗传因素的影响。目前其发病机制尚未明确。固有淋巴细胞是T淋巴细胞的先天对应细胞,缺乏遗传因素重组产生的适应性抗原受体。其中2型固有淋巴细胞(group 2 innate lymphoid celles, ILC2s)激活后释放大量2型细胞因子,与Th2免疫反应密切相关。论文就慢性鼻窦炎伴鼻息肉中ILC2s的作用及其调节机制,尤其是与调节性T细胞之间的相互作用进行综述。

关键词: 2型固有淋巴细胞, 鼻窦炎, 鼻息肉, Th2炎症, 调节性T细胞

Abstract: Chronic rhinosinusitis is a chronic inflammatory disease that occurs in the mucosa of the sinuses, mainly manifested by nasal symptoms such as nasal congestion and runny nose, followed by head and facial swelling, and decreased or lost sense of smell. The course of disease is no less than 12 weeks. It is often complicated with respiratory diseases such as asthma and chronic obstructive pulmonary disease. As an inflammatory disease with a multifactorial etiology, it involves the immune system and epithelial barrier and is influenced by microbiota, environmental and genetic factors. Its pathogenesis is not yet clear. Innate lymphoid cells are the innate counterparts of T lymphocytes and lack adaptive antigen receptors generated by recombination of genetic factors. Among them, group 2 innate lymphoid cells(ILC2s)release large amounts of type 2 cytokines after activation, which is closely related to Th2 inflammation. This article reviews the role of ILC2s in chronic rhinosinusitis with nasal polyps and its regulatory mechanism, especially its interaction with regulatory T cells.

Key words: Group 2 innate lymphoid cells, Sinusitis, Nasal polyps, Th2 inflammation, Regulatory T cells

中图分类号: 

  • R765.4+
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