会厌原发神经内分泌癌1例并文献复习

doi:10.6040/j.issn.1673-3770.0.2023.337

摘要/Abstract

摘要： 目的探讨喉神经内分泌癌的临床表现、病理类型、治疗手段及预后。方法回顾1例会厌原发神经内分泌癌患者的临床资料并复习相关文献。结果喉神经内分泌癌的确诊主要依靠病理学检查,病理类型不同,肿瘤的生物学行为、治疗方案及患者预后均存在显著差异。结论喉神经内分泌癌治疗仍有争议,最佳治疗方案仍未确定,对于术后淋巴结转移阳性的患者,辅以放疗可能有助于提高患者预后,对于颈淋巴结阴性的患者,是否有必要放化疗仍值得商榷。

关键词: 会厌, 神经内分泌癌, 喉, 放射治疗

Abstract: Objective This study aims to investigate the clinical manifestations, pathological types, treatment modalities, and prognosis of laryngeal neuroendocrine carcinoma. Methods The clinical data from a case of neuroendocrine carcinoma are presented, accompanied by a comprehensive review of related literature. Results A diagnosis of laryngeal neuroendocrine carcinoma was primarily established through pathological examination. The literature revealed significant differences in biological behavior, treatment approaches, and prognosis among various pathological types. Conclusion The best practice for treating laryngeal neuroendocrine carcinoma remains controversial, with no established gold standard treatment plan in cases where postoperative lymph nodes show metastasis, radiotherapy may contribute to an improved prognosis However, for patients with negative lymph nodes, the necessity of radiotherapy and chemotherapy remains uncertain.

Key words: Epiglottis, Neuroendocrine carcinoma, Throat, Radiotherapy

中图分类号:

R767.5

刘玉柱,苑铁君,李波. 会厌原发神经内分泌癌1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 97-100.

LIU Yuzhu, YUAN Tiejun, LI Bo. Primary epiglottic neuroendocrine carcinoma: a case report and literature review[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 97-100.

参考文献

[1] Strojan P, Šifrer R, Ferlito A, et al. Neuroendocrine carcinoma of the larynx and pharynx: a clinical and histopathological study[J]. Cancers, 2021, 13(19): 4813. doi:10.3390/cancers13194813
[2] Ghosh R, Dutta R, Dubal PM, et al. Laryngeal neuroendocrine carcinoma: a population-based analysis of incidence and survival[J]. Otolaryngol Head Neck Surg, 2015, 153(6): 966-972. doi:10.1177/0194599815594386
[3] Wang Y, Liu DL, She CP. Clinical diagnosis and treatment of primary laryngeal neuroendocrine carcinoma[J]. Ear Nose Throat J, 2023: 1455613231155853. doi:10.1177/01455613231155853
[4] 余冉, 刘世喜. 喉神经内分泌癌的研究进展[J]. 西部医学, 2023, 35(9): 1400-1404 YU Ran, LIU Shixi. Update on neuroendocrine carcinomas of the larynx[J]. Medical Journal of West China, 2023, 35(9): 1400-1404
[5] 毛泽凡, 陈曦, 程雷. 喉神经内分泌癌的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 114-119. doi:10.6040/j.issn.1673-3770.1.2021.152 MAO Zefan, CHEN Xi, CHENG Lei. Research advances in neuroendocrine carcinoma of the larynx[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 114-119. doi:10.6040/j.issn.1673-3770.1.2021.152
[6] 代元飞, 吕星旺, 魏洁. 舌根部神经内分泌癌1例[J]. 临床肿瘤学杂志, 2021, 26(5): 479-480. doi:10.3969/j.issn.1009-0460.2021.05.016 DAI Yuanfei, LÜ Xingwang, WEI Jie. A case of neuroendocrine carcinoma at the base of tongue[J]. Chinese Clinical Oncology, 2021, 26(5): 479-480. doi:10.3969/j.issn.1009-0460.2021.05.016
[7] 钱敏, 沈月洪, 吴利, 等. 舌根转移性小细胞神经内分泌癌1例报告及文献复习[J]. 中国口腔颌面外科杂志, 2022, 20(2): 202-205. doi:10.19438/j.cjoms.2022.02.019 QIAN Min, SHEN Yuehong, WU Li, et al. Metastatic small cell neuroendocrine carcinoma of tongue base: a case report and review[J]. China Journal of Oral and Maxillofacial Surgery, 2022, 20(2): 202-205. doi:10.19438/j.cjoms.2022.02.019
[8] Faquin WC. High-risk HPV and neuroendocrine carcinomas of the head and neck[J]. Cancer Cytopathol, 2019, 127(1): 13-14. doi:10.1002/cncy.22094
[9] 赵春丽, 路承, 张奥博, 等. 扁桃体原发神经内分泌癌2例[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(23): 1904-1906. doi:10.13201/j.issn.1001-1781.2016.23.018 ZHAO Chunli, LU Cheng, ZHANG Aobo, et al. Primary neuroendocrine carcinoma of the tonsil: two case reports and review of the literature[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2016, 30(23): 1904-1906. doi:10.13201/j.issn.1001-1781.2016.23.018
[10] 汤英姿, 吕亮, 于晓东, 等. 喉神经内分泌癌2例[J]. 临床与实验病理学杂志, 2021, 37(8): 1015-1016. doi:10.13315/j.cnki.cjcep.2021.08.031 TANG Yingzi, LÜ Liang, YU Xiaodong, et al. Two cases of laryngeal neuroendocrine carcinoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2021, 37(8): 1015-1016. doi:10.13315/j.cnki.cjcep.2021.08.031
[11] 袁波, 王荟, 张治军. 喉小细胞神经内分泌癌一例并文献复习[J]. 海南医学, 2021, 32(8): 1076-1078. doi:10.3969/j.issn.1003-6350.2021.08.033 YUAN Bo, WANG Hui, ZHANG Zhijun. Small cell neuroendocrine carcinoma of larynx: a case report and literature review[J]. Hainan Medical Journal, 2021, 32(8): 1076-1078. doi:10.3969/j.issn.1003-6350.2021.08.033
[12] Strosberg C, Ferlito A, Triantafyllou A, et al. Update on neuroendocrine carcinomas of the larynx[J]. Am J Clin Pathol, 2019, 152(6): 686-700. doi:10.1093/ajcp/aqz106
[13] 刘其鑫, 申霖, 申良方. 喉大细胞神经内分泌癌1例[J]. 中国耳鼻咽喉头颈外科, 2022, 29(7): 468. doi:10.16066/j.1672-7002.2022.07.016 LIU Qixin, SHEN Lin, SHEN Liangfang. Large cell neuroendocrine carcinoma of larynx: a case report[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2022, 29(7): 468. doi:10.16066/j.1672-7002.2022.07.016
[14] Mete O, Wenig BM. Update from the 5th edition of the World Health Organization classification of head and neck tumors: overview of the 2022 WHO classification of head and neck neuroendocrine neoplasms[J]. Head Neck Pathol, 2022, 16(1): 123-142. doi:10.1007/s12105-022-01435-8
[15] 陈学军, 高文, 尹高菲, 等. 鼻腔鼻窦神经内分泌癌8例并文献复习[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 77-82. doi:10.6040/j.issn.1673-3770.0.2020.537 CHEN Xuejun, GAO Wen, YIN Gaofei, et al. Neuroendocrine carcinoma of the nasal cavity and paranasal sinus: eight cases and literature review[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 77-82. doi:10.6040/j.issn.1673-3770.0.2020.537
[16] Wang QY, Chen HH, Zhou SH. Typical laryngeal carcinoid tumor with recurrence and lymph node metastasis: a case report and review of the literature[J]. Int J Clin Exp Pathol, 2014, 7(12): 9028-9031
[17] Pein MK, Holzhausen H, K sling S, et al. Atypical carcinoid of the larynx. Case report and review of literature[J]. HNO, 2010, 58(8): 812-817. doi:10.1007/s00106-010-2081-2
[18] Hanakawa H, Inokuchi I, Ayada N, et al. Laryngeal atypical carcinoid combined with squamous cell carcinoma: a case report[J]. Nihon Jibiinkoka Gakkai Kaiho, 2015, 118(1): 34-39. doi:10.3950/jibiinkoka.118.34
[19] Pointer KB, Ko HC, Brower JV, et al. Small cell carcinoma of the head and neck: an analysis of the National Cancer Database[J]. Oral Oncol, 2017, 69: 92-98. doi:10.1016/j.oraloncology.2017.04.009
[20] 张瑾, 丁德涛, 宋攀攀, 等. 喉神经内分泌癌1例[J]. 中国耳鼻咽喉头颈外科, 2023, 30(8): 537-538. doi:10.16066/j.1672-7002.2023.08.016 ZHANG Jin, DING Detao, SONG Panpan, et al. A case of laryngeal neuroendocrine carcinoma[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2023, 30(8): 537-538. doi:10.16066/j.1672-7002.2023.08.016
[21] Gillenwater A, Lewin J, Roberts D, et al. Moderately differentiated neuroendocrine carcinoma(atypical carcinoid)of the larynx: a clinically aggressive tumor[J]. Laryngoscope, 2005, 115(7): 1191-1195. doi:10.1097/01.MLG.0000166179.40750.1B

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