microRNA在鼻咽癌中的作用及其研究进展

doi:10.6040/j.issn.1673-3770.0.2023.339

摘要/Abstract

摘要： 鼻咽癌是一种发生于鼻咽黏膜的上皮性恶性肿瘤,多数患者伴有潜伏性EB病毒感染,在亚洲人群中较为常见。在鼻咽癌中,微小RNA(microRNA, miRNA)同时具有抑癌基因和致癌基因的功能,miRNA通过调控参与多种细胞过程和通路的特异靶基因,在鼻咽癌的发病机制中发挥重要作用。miRNAs的失调与鼻咽癌患者预后和临床结果有关,miRNA及其靶基因可作为治疗靶点改善鼻咽癌对放疗和化疗的敏感性。因此,了解miRNA的重要特征与其在鼻咽癌诊断、预后评估及治疗中的应用具有重要的临床价值。

关键词: 鼻咽癌, 微小RNA, EB病毒, 生物标志物

Abstract: Nasopharyngeal carcinoma is a type of cancer that affects the mucous membrane in the nasopharynx. It is often associated with latent Epstein-Barr virus infection and is most common in the Asian population. In this type of cancer, microRNA(miRNA)plays a crucial role as both a tumor suppressor and an oncogene. By regulating specific target genes involved in various cellular processes and pathways, miRNA contributes to the development of nasopharyngeal carcinoma, and miRNA disorder is also related to patient prognosis and clinical outcome. Targeting miRNAs and their associated genes can be used as a therapeutic approach to enhance the sensitivity of nasopharyngeal carcinoma to radiotherapy and chemotherapy. Therefore, understanding the characteristics of miRNA and its application in the diagnosis, prognosis evaluation, and treatment of nasopharyngeal carcinoma is of great clinical importance.

Key words: Nasopharyngeal carcinoma, MicroRNA, EB virus, Biomarker

中图分类号:

R739.6

王盛,李银丹,杨金姬. microRNA在鼻咽癌中的作用及其研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 125-131.

WANG Sheng, LI Yindan, YANG Jinji. The role of microRNA in nasopharyngeal carcinoma and its research progress[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 125-131.

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