ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (6): 46-54.doi: 10.6040/j.issn.1673-3770.0.2024.122
• 研究进展 • 上一篇
张杉,陈秋,周方伟,马亦飞
ZHANG Shan, CHEN Qiu, ZHOU Fangwei, MA Yifei
摘要： 咽喉反流性疾病(laryngopharyngeal reflux disease, LPRD)是耳鼻咽喉科一种常见的疾病,目前LPRD的诊断标准尚不统一,以临床表现结合多种辅助检查为主要诊断方法。在LPRD患者中,存在某些含量与正常人群有差异的物质,可以通过各种机制导致咽喉部黏膜损伤。与LPRD发病相关的生物标志物众多,除最常见的反流物质胃酸外,近年越来越多的物质受到了关注。如胃蛋白酶、胰蛋白酶、神经源性炎症因子、胆汁酸、紧密连接蛋白、碳酸酐酶、黏蛋白、基质金属蛋白酶-7以及细胞钙黏蛋白等。生物标志物具有较高的特异性、敏感性及高效性,可以减少喉镜、pH阻抗监测等诊断仪器设备的使用。因此建立LPRD生物标志物诊断体系,可以帮助LPRD诊断更加便捷、准确。现总结LPRD相关生物标志物,回顾其在LPRD诊疗过程的研究进展。
中图分类号:
| [1] Lechien JR, Schindler A, De Marrez LG, et al. Instruments evaluating the clinical findings of laryngopharyngeal reflux: a systematic review[J]. Laryngoscope, 2019, 129(3): 720-736. doi:10.1002/lary.27537 [2] Sereg-Bahar M, Jerin A, Jansa R, et al. Pepsin and bile acids in saliva in patients with laryngopharyngeal reflux - a prospective comparative study[J]. Clin Otolaryngol, 2015, 40(3): 234-239. doi:10.1111/coa.12358 [3] Lechien JR, Finck C, Khalife M, et al. Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease[J]. Clin Otolaryngol, 2018, 43(5): 1273-1282. doi:10.1111/coa.13140 [4] 徐志宇, 刘旭, 陈世彩, 等. 咽喉反流性疾病的发病机制及其与耳鼻咽喉疾病相关性研究进展[J]. 听力学及言语疾病杂志, 2022, 30(6): 587-590. doi:10.3969/j.issn.1006-7299.2022.06.004 [5] Lechien JR, Chiesa-Estomba CM, Calvo Henriquez C, et al. Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: a systematic review[J]. PLoS One, 2020, 15(8): e0237581. doi:10.1371/journal.pone.0237581 [6] Lechien J R, Saussez S, Nacci A, et al. Association between laryngopharyngeal reflux and benign vocal folds lesions: A systematic review[J]. Laryngoscope, 2019,129(9):E329-E341. doi:10.1002/lary.27932 [7] 赵博, 杨启梅, 王鑫, 等. 咽喉反流与分泌性中耳炎的相关研究进展[J]. 听力学及言语疾病杂志, 2018, 26(6): 681-684. doi:10.3969/j.issn.1006-7299.2018.06.028 [8] Lechien JR. Personalized treatments based on laryngopharyngeal reflux patient profiles: a narrative review[J]. J Pers Med, 2023, 13(11): 1567. doi:10.3390/jpm13111567 [9] 郎永耀, 杨云, 刘晴, 等. 咽喉反流性疾病的影响因素及治疗效果分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 119-123. doi:10.6040/j.issn.1673-3770.0.2018.472 LANG Yongyao, YANG Yun, LIU Qing, et al. Analysis of influencing factors and observation of therapeutic effects in patients with laryngopharyngeal reflux disease[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 119-123. doi:10.6040/j.issn.1673-3770.0.2018.472 [10] Lechien Jerome R,Saussez Sven,Karkos Petros D.Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018[J].Curr Opin Otolaryngol Head Neck Surg, 2018, 26: 392-402.doi: 10.1097/MOO.0000000000000486. [11] Brown J, Shermetaro C. Laryngopharyngeal Reflux[M].Treasure Island(FL): StatPearls Publishing,2024,Jan. PMID: 30137832. [12] McCormick CA, Samuels TL, Battle MA, et al. H+/K+ATPase expression in the larynx of laryngopharyngeal reflux and laryngeal cancer patients[J]. Laryngoscope, 2021, 131(1): 130-135. doi:10.1002/lary.28643 [13] Becker V, Bajbouj M, Waller K, et al. Clinical trial: persistent gastro-oesophageal reflux symptoms despite standard therapy with proton pump inhibitors-a follow-up study of intraluminal-impedance guided therapy[J]. Aliment Pharmacol Ther, 2007, 26(10): 1355-1360. doi:10.1111/j.1365-2036.2007.03529.x [14] Becker V, Drabner R, Graf S, et al. New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease[J]. World J Gastroenterol, 2015, 21(3): 982-987. doi:10.3748/wjg.v21.i3.982 [15] Li YD, Xu GF, Zhou BD, et al. Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets[J]. Eur Arch Otorhinolaryngol, 2022, 279(6): 2743-2752. doi:10.1007/s00405-021-07201-w [16] 郑彦焱, 颜冬惠, 陈十燕, 等. 胃蛋白酶在不同pH条件下对咽喉黏膜上皮的作用[J/OL]. 听力学及言语疾病杂志,2024:1-5(2024-01-15). https://kns.cnki.net/kcms/detail/42.1391.R.20240111.1707.008.html. ZHENG Yanyan, YAN Donghui, CHEN Shiyan, et al. The effects of pepsin on the mucosal epithelium of the laryngopharynx under different pH condition[J/OL]. Journal of Audiology and Speech Pathology, 2024: 1-5(2024-01-15). https://kns.cnki.net/kcms/detail/42.1391.R.20240111.1707.008.html. [17] 李进让. 咽喉反流性疾病规范化诊断和治疗[J]. 中国耳鼻咽喉头颈外科, 2015, 22(9): 435-437. doi:10.16066/j.1672-7002.2015.09.001 [18] Formánek M, Jan catová D,Komínek P et al. Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis(prospective case-control study)[J].Clin Otolaryngol,2017,42(3):597-601. doi: 10.1111/coa.12779 [19] Zub ci c Ž, Mendeš T, V ceva A, et al. Presence of pepsin in laryngeal tissue and saliva in benign and malignant neoplasms[J]. Biosci Rep, 2020, 40(11): BSR20200216. doi:10.1042/BSR20200216 [20] 陶艳丽, 苑铁君. 唾液胃蛋白酶检测在反流性咽喉炎诊断中的价值[J]. 山东大学耳鼻喉眼学报, 2018, 32(6): 52-55. doi:10.6040/j.issn.1673-3770.0.2018.219 TAO Yanli, YUAN Tiejun. Diagnostic value of detection of pepsin in the saliva for laryngopharyngeal reflux[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 52-55. doi:10.6040/j.issn.1673-3770.0.2018.219 [21] Hurley BP, Jugo RH, Snow RF, et al. Pepsin triggers neutrophil migration across acid damaged lung epithelium[J]. Sci Rep, 2019, 9(1): 13778. doi:10.1038/s41598-019-50360-4 [22] Gtari W, Bey H, Aschi A, et al. Impact of macromolecular crowding on structure and properties of pepsin and trypsin[J]. Mater Sci Eng C Mater Biol Appl, 2017, 72: 98-105. doi:10.1016/j.msec.2016.11.046 [23] Kowalik K, Krzeski A. The role of pepsin in the laryngopharyngeal reflux[J]. Otolaryngol Pol, 2017, 71(6): 7-13. doi:10.5604/01.3001.0010.7194 [24] Samuels TL, Zimmermann MT, Zeighami A, et al. RNA sequencing reveals cancer-associated changes in laryngeal cells exposed to non-acid pepsin[J]. Laryngoscope, 2021, 131(1): 121-129. doi:10.1002/lary.28636 [25] Tan JJ, Wang L, Mo TT, et al. Pepsin promotes IL-8 signaling-induced epithelial–mesenchymal transition in laryngeal carcinoma[J]. Cancer Cell Int, 2019, 19(1): 64. doi:10.1186/s12935-019-0772-7 [26] Johnston N, Yan JC, Hoekzema CR, et al. Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells[J]. Laryngoscope, 2012, 122(6): 1317-1325. doi:10.1002/lary.23307 [27] Wang CP, Wang CC, Lien HC, et al. Saliva pepsin detection and proton pump inhibitor response in suspected laryngopharyngeal reflux[J]. Laryngoscope, 2019, 129(3): 709-714. doi:10.1002/lary.27502 [28] 万苡辰, 闫燕, 马芙蓉. 咽喉反流的机制及诊断方法[J]. 听力学及言语疾病杂志, 2013, 21(2): 200-204. doi:10.3969/j.issn.1006-7299.2013.02.032 [29] Landry V, Coburn P, Kost K, et al. Diagnostic accuracy of liquid biomarkers in airway diseases: toward point-of-care applications[J]. Front Med, 2022, 9: 855250. doi:10.3389/fmed.2022.855250 [30] 高竞逾, 罗仁婧, 阮标, 等. 胃蛋白酶免疫组织化学与胃蛋白酶检测试剂盒在咽喉反流诊断中的一致性分析[J]. 临床耳鼻咽喉头颈外科杂志, 2023, 37(2): 97-102, 106. doi:10.13201/j.issn.2096-7993.2023.02.004 GAO Jingyu, LUO Renjing, RUAN Biao, et al. Consistency analysis of pepsin immunohistochemistry and pepsin test box in the diagnosis of laryngopharyngeal reflux[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2023, 37(2): 97-102, 106. doi:10.13201/j.issn.2096-7993.2023.02.004 [31] Saritas Yuksel E, Hong SK, Strugala V, et al. Rapid salivary pepsin test: blinded assessment of test performance in gastroesophageal reflux disease[J]. Laryngoscope, 2012, 122(6): 1312-1316. doi:10.1002/lary.23252 [32] Bor S, Capanoglu D, Vardar R, et al. Validation of peptestTM in patients with gastro-esophageal reflux disease and laryngopharyngeal reflux undergoing impedance testing[J]. J Gastrointestin Liver Dis, 2019, 28(4): 383-387. doi:10.15403/jgld-335 [33] Na SY, Kwon OE, Lee YC, et al. Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux[J]. Laryngoscope, 2016, 126(12): 2770-2773. doi:10.1002/lary.26018 [34] Klimara MJ, Johnston N, Samuels TL, et al. Correlation of salivary and nasal lavage pepsin with MII-pH testing[J]. Laryngoscope, 2020, 130(4): 961-966. doi:10.1002/lary.28182 [35] Jing WY, Luo WL, Lou L. Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis[J]. Braz J Otorhinolaryngol, 2023, 89(2): 339-347. doi:10.1016/j.bjorl.2022.10.050 [36] Pearson JP, Parikh S, Orlando RC, et al. Review article: reflux and its consequences: the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin(ISHP)Kingston-upon-Hull, UK, 21-23 April 2010[J]. Aliment Pharmacol Ther, 2011, 33(1): 1-71. doi:10.1111/j.1365-2036.2011.04581.x [37] Naito Y, Uchiyama K, Kuroda M, et al. Role of pancreatic trypsin in chronic esophagitis induced by gastroduodenal reflux in rats[J]. J Gastroenterol, 2006, 41(3): 198-208. doi:10.1007/s00535-005-1742-5 [38] Tanaka Y, Ihara E, Hirano K, et al. Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter[J]. Eur J Pharmacol, 2015, 752: 97-105. doi:10.1016/j.ejphar.2015.02.008 [39] Bai XP, Tanaka Y, Ihara E, et al. Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body[J]. Eur J Pharmacol, 2017, 797: 65-74. doi:10.1016/j.ejphar.2017.01.004 [40] Cao J, Zhang LH, Liu YJ, et al. Properties of a novel animal model of LPRD[J]. J Voice, 2021, 35(5): P805.e17-805.e26. doi:10.1016/j.jvoice.2020.01.021 [41] Silva RO, Bingana RD, Sales TMAL, et al. Role of TRPV1 receptor in inflammation and impairment of esophageal mucosal integrity in a murine model of nonerosive reflux disease[J]. Neurogastroenterol Motil, 2018: e13340. doi:10.1111/nmo.13340 [42] Suzuki N, Mihara H, Nishizono H, et al. Protease-activated receptor-2 up-regulates transient receptor potential vanilloid 4 function in mouse esophageal keratinocyte[J]. Dig Dis Sci, 2015, 60(12): 3570-3578. doi:10.1007/s10620-015-3822-6 [43] De Corso E, Baroni S, Agostino S, et al. Bile acids and total bilirubin detection in saliva of patients submitted to gastric surgery and in particular to subtotal Billroth II resection[J]. Ann Surg, 2007, 245(6): 880-885. doi:10.1097/01.sla.0000255574.22821.a1 [44] Wang L, Liu X, Liu YL, et al. Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs[J]. Otolaryngol Head Neck Surg, 2010, 143(6): 765-771. doi:10.1016/j.otohns.2010.08.018 [45] Fiorucci S, Distrutti E, di Matteo F, et al. Circadian variations in gastric acid and pepsin secretion and intragastric bile acid in patients with reflux esophagitis and in healthy controls[J]. Am J Gastroenterol, 1995, 90(2): 270-276 [46] Sereg-Bahar M, Jerin A, Jansa R, et al. Pepsin and bile acids in saliva in patients with laryngopharyngeal reflux - a prospective comparative study[J]. Clin Otolaryngol, 2015, 40(3): 234-239. doi:10.1111/coa.12358 [47] De Corso E, Baroni S, Salonna G, et al. Impact of bile acids on the severity of laryngo-pharyngeal reflux[J]. Clin Otolaryngol, 2021, 46(1): 189-195. doi:10.1111/coa.13643 [48] Laird JM, Olivar T, Roza C, et al. Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene[J]. Neuroscience, 2000, 98(2): 345-352. doi:10.1016/s0306-4522(00)00148-2 [49] Ali MS, Parikh S, Chater P, et al. Bile acids in laryngopharyngeal refluxate: will they enhance or attenuate the action of pepsin?[J]. Laryngoscope, 2013, 123(2): 434-439. doi:10.1002/lary.23619 [50] Sereg-Bahar M, Jerin A, Hocevar-Boltezar I. Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer[J]. Radiol Oncol, 2015, 49(1): 59-64. doi:10.2478/raon-2014-0020 [51] Vageli DP, Doukas SG, Doukas PG, et al. Bile reflux and hypopharyngeal cancer(Review)[J]. Oncol Rep, 2021, 46(5): 244. doi:10.3892/or.2021.8195 [52] Galli J, Calò L, Agostino S, et al. Bile reflux as possible risk factor in laryngopharyngeal inflammatory and neoplastic lesions[J]. Acta Otorhinolaryngol Ital, 2003, 23(5): 377-382 [53] De Corso E, Baroni S, Agostino S, et al. Bile acids and total bilirubin detection in saliva of patients submitted to gastric surgery and in particular to subtotal Billroth II resection[J]. Ann Surg, 2007, 245(6): 880-885. doi:10.1097/01.sla.0000255574.22821.a1 [54] 王刚,林春兰,刘蔓林,等.咽喉反流性疾病中SP、NK-1R、IL-8、PGP9.5的表达及意义[J].听力学及言语疾病杂志,2022, 30(6): 582-586. doi:10.3969/i.issn.1006-7299.2022.06.003 WANG Gang, LIN Chunlan, LIU Manlin, et al. Expression and Significance of SP, NK-1R, IL-8, PGP9.5 in Laryngopharyngeal Reflux Disease[J]. Journal of Audiology and Speech Pathology, 2022, 30(6): 582-586. doi:10.3969/i.issn.1006-7299.2022.06.003 [55] 孙建梅, 刘彤彤, 唐宗湘. 神经源性炎症痛的分子机制及研究进展[J]. 中国疼痛医学杂志, 2022, 28(7): 486-493. doi:10.3969/j.issn.1006-9852.2022.07.003 SUN Jianmei, LIU Tongtong, TANG Zongxiang. Molecular mechanism and research progress of neurogenic inflammatory pain[J]. Chinese Journal of Pain Medicine, 2022, 28(7): 486-493. doi:10.3969/j.issn.1006-9852.2022.07.003 [56] Wood JM, Hussey DJ, Woods CM, et al. Biomarkers and laryngopharyngeal reflux[J]. J Laryngol Otol, 2011, 125(12): 1218-1224. doi:10.1017/S0022215111002234 [57] Chen W, Zhang Y, Cheng Y, et al. The role of NF-κB signaling pathway in laryngeal leukoplakia recurrent with laryngeal reflux[J]. Chin J Otorhinolaryngol Head Neck Surg, 2018, 53(8): 597-603. doi:10.3760/cma.j.issn.1673-0860.2018.08.008 [58] 曹杰, 张立红, 王文伦, 等. 白细胞介素-8在兔咽喉反流中的作用[J]. 中国耳鼻咽喉颅底外科杂志, 2020, 26(3): 278-282. doi:10.11798/j.issn.1007-1520.202003010 CAO Jie, ZHANG Lihong, WANG Wenlun, et al. A preliminary study on the role of interleukin-8(IL-8)in laryngopharyngeal reflux of rabbits[J]. Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2020, 26(3): 278-282. doi:10.11798/j.issn.1007-1520.202003010 [59] 李明航, 刘海林, 刁俊玲, 等. 紧密连接蛋白Claudin-3的研究进展[J]. 现代医药卫生, 2022, 38(11): 1896-1899. doi:10.3969/j.issn.1009-5519.2022.11.022 [60] Zeissig S, Bürgel N, Günzel D, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease[J]. Gut, 2007, 56(1): 61-72. doi:10.1136/gut.2006.094375 [61] Oguro M, Koike M, Ueno T, et al. Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease[J]. J Gastroenterol, 2011, 46(5): 629-638. doi:10.1007/s00535-011-0390-1 [62] Björkman EVC, Edebo A, Oltean M, et al. Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro[J]. Scand J Gastroenterol, 2013, 48(10): 1118-1126. doi:10.3109/00365521.2013.828772 [63] Xu XB, Hu Y, Wang Y, et al. Expression of claudin-3 in the esophagus and larynx of rat reflux model[J]. Auris Nasus Larynx, 2014, 41(6): 539-542. doi:10.1016/j.anl.2014.05.011 [64] Meloni M, Buratti P, Carriero F, et al. In vitro modelling of barrier impairment associated with gastro-oesophageal reflux disease(GERD)[J]. Clin Exp Gastroenterol, 2021, 14: 361-373. doi:10.2147/CEG.S325346 [65] Okimoto K, Arai M, Ishigami H, et al. A prospective study of eosinophilic esophagitis and the expression of tight junction proteins in patients with gastroesophageal reflux disease symptoms[J]. Gut Liver, 2018, 12(1): 30-37. doi:10.5009/gnl16600 [66] 李秋霞, 罗茂林, 李茹柳, 等. 紧密连接蛋白ZO-1研究概述[J]. 广州中医药大学学报, 2007, 24(6): 523-526. doi:10.3969/j.issn.1007-3213.2007.06.024 [67] Neumann H, Mönkemüller K, Fry LC, et al. Intercellular space volume is mainly increased in the basal layer of esophageal squamous epithelium in patients with GERD[J]. Dig Dis Sci, 2011, 56(5): 1404-1411. doi:10.1007/s10620-010-1458-0 [68] Orlando LA, Orlando RC. Dilated intercellular spaces as a marker of GERD[J]. Curr Gastroenterol Rep, 2009, 11(3): 190-194. doi:10.1007/s11894-009-0030-6 [69] 吴昆旻, 李泽卿, 朱春晖, 等. 紧密连接蛋白在声带白斑伴咽喉反流患者声带黏膜中的表达[J]. 中国耳鼻咽喉颅底外科杂志, 2017, 23(6): 541-545. doi:10.11798/j.issn.1007-1520.201706009 WU Kunmin, LI Zeqing, ZHU Chunhui, et al. Expressions of tight junction proteins in vocal mucosa of patients suffering from vocal leukoplakia accompanied with laryngopharyngeal reflux[J]. Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2017, 23(6): 541-545. doi:10.11798/j.issn.1007-1520.201706009 [70] Gill GA, Buda A, Moorghen M, et al. Characterisation of adherens and tight junctional molecules in normal animal larynx; determining a suitable model for studying molecular abnormalities in human laryngopharyngeal reflux[J]. J Clin Pathol, 2005, 58(12): 1265-1270. doi:10.1136/jcp.2004.016972 [71] 郝梅, 蒋兴旺, 陈浩, 等. 睡眠剥夺大鼠喉上皮细胞屏障功能改变在咽喉反流发病机制中的作用[J]. 听力学及言语疾病杂志, 2022, 30(6): 577-581. doi:10.3969/j.issn.1006-7299.2022.06.002 HAO Mei, JIANG Xingwang, CHEN Hao, et al. The role of barrier function of laryngeal epithelial cells in the pathogenesis of laryngopharyngeal reflux in sleep deprived rats[J]. Journal of Audiology and Speech Pathology, 2022, 30(6): 577-581. doi:10.3969/j.issn.1006-7299.2022.06.002 [72] Campagnolo AM, Priston J, Thoen RH, et al. Laryngopharyngeal reflux: diagnosis, treatment, and latest research[J]. Int Arch Otorhinolaryngol, 2014, 18(2): 184-191. doi:10.1055/s-0033-1352504 [73] Johnston N, Dettmar PW, Bishwokarma B, et al. Activity/stability of human pepsin: implications for reflux attributed laryngeal disease[J]. Laryngoscope, 2007, 117(6): 1036-1039. doi:10.1097/MLG.0b013e31804154c3 [74] Johnston N, Knight J, Dettmar PW, et al. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease[J]. Laryngoscope, 2004, 114(12): 2129-2134. doi:10.1097/01.mlg.0000149445.07146.03 [75] Johnston N, Bulmer D, Gill GA, et al. Cell biology of laryngeal epithelial defenses in health and disease: further studies[J]. Ann Otol Rhinol Laryngol, 2003, 112(6): 481-491. doi:10.1177/000348940311200601 [76] Im NR, Lee DY, Kim B, et al. Role of matrix metalloproteinases 7 in the pathogenesis of laryngopharyngeal reflux: decreased E-cadherin in acid exposed primary human pharyngeal epithelial cells[J]. Int J Mol Sci, 2019, 20(21): 5276. doi:10.3390/ijms20215276 [77] Im NR, Kim B, Jung KY, et al. Correction to: matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway[J]. J Mol Med, 2022, 100(7): 1091. doi:10.1007/s00109-022-02212-4 [78] Lechien JR, Mouawad F, Bobin F, et al. Review of management of laryngopharyngeal reflux disease[J]. Eur Ann Otorhinolaryngol Head Neck Dis, 2021, 138(4): 257-267. doi:10.1016/j.anorl.2020.11.002 |
| [1] | 吴玮,王磊,陈升,李连勇,王刚. 胃食管气道反流性疾病多学科研究及进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 1-14. |
| [2] | 刘莲莲,李进让. 阻塞性睡眠呼吸暂停与咽喉反流[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 15-22. |
| [3] | 张利,张梦茹,阿丽米热·艾尔肯,邱忠民. 咽喉反流性疾病在常见呼吸道疾病中的作用[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 23-29. |
| [4] | 胡志伟,陈冬,杨栋,吴继敏. 胃食管气道反流性疾病的诊断和治疗:基于2020~2024年相关共识和指南[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 30-38. |
| [5] | 赵佳宁,崔元馨,王丹,赵明. 咽喉反流与复发性呼吸道乳头状瘤病的关系及其机制探讨[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 39-45. |
| [6] | 王璐,张云云,郭华,崔小川. 脂质代谢标志物在早期筛查阻塞性睡眠呼吸暂停患者中阿尔兹海默症的应用价值[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 68-74. |
| [7] | 王磊,李保卫,王刚,刘红丹,韩浩伦,张晓丽,吴玮. 阻塞性睡眠呼吸暂停低通气综合征患者夜间碱反流初步研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 75-79. |
| [8] | 张竹萍,叶琪,郭蓓,林凌. 叶酸受体阳性循环肿瘤细胞检测在喉鳞状细胞癌诊断中的应用价值[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 50-53. |
| [9] | 邵娜,张青青,刘小红,谢萌,郭瑞昕,马思敬,刘海琴,任晓勇,罗花南. 幽门螺旋杆菌感染对症状性咽喉反流患者唾液胃蛋白酶浓度的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 89-95. |
| [10] | 秦铭,孙占伟,王卫卫,李世超,武天义,王广科. 咽喉反流症状或体征评分阳性的慢性鼻窦炎患者鼻内镜术后碱性等渗盐水冲洗的疗效观察[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 147-153. |
| [11] | 曾宪廷,王广科,孙占伟,武天义,李世超,王卫卫. 伴咽喉反流的难治性鼻窦炎术后应用质子泵抑制剂的疗效观察[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 189-194. |
| [12] | 侯波,梁程程,魏东敏,雍蓉,雷大鹏,李梅. 耳鼻咽喉门诊咽喉良性病变老年患者喉镜观察与嗓音声学分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 20-25. |
| [13] | 吴迪盼盼,崔新华,郭颖,耿博,高芳芳,梁辉. 窄带成像技术在咽喉反流诊断中的优势应用[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 31-36. |
| [14] | 张轶轶,薛刚,金春亭. 外泌体在甲状腺癌的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 131-135. |
| [15] | 王宏艳,王三春滕博,葛敏. 阻塞性睡眠呼吸暂停综合征与咽喉反流性疾病相关研究进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(4): 134-138. |
|
||