Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (2): 110-114.doi: 10.6040/j.issn.1673-3770.0.2019.530

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Prognostic role of preoperative fibrinogen levels in patients with laryngeal squamous cell carcinoma

CHEN Huijun, SONG Shenghua, DONG Weida, ZHOU Han   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Published:2020-04-07

Abstract: Objective This study aimed to evaluate the impact of preoperative fibrinogen(FIB)on the prognosis of patients with laryngeal squamous cell carcinoma. Methods The clinical data of 458 patients with laryngeal squamous cell carcinoma who underwent primary surgery in the First Affiliated Hospital of Nanjing Medical University were analyzed retrospectively. On observation of preoperative FIB levels, a receiver operating characteristic curve(ROC)was drawn to determine the FIB threshold, and then the patients were divided into lower and higher groups. Chi-square test, Kaplan-Meier analysis and Cox risk model were used to analyze the relationship between FIB, other clinicopathological parameters and overall survival. Results The area under the ROC curve(AUC)of FIB for overall survival(OS)of patients with laryngeal squamous cell carcinoma was 0.67. Univariate analysis showed that FIB, tumor classification, TNM stages, pathological differentiation, invasion of thyroid cartilage plate, lymph nodes metastasis and age were associated with OS of patients with laryngeal squamous cell carcinoma. Cox regression model identified high FIB level, TNM stages III and IV, and age as independent risk factors for the OS of patients with laryngeal squamous cell carcinoma (P<0.001; P=0.014; P=0.003). Conclusion Patients with laryngeal squamous cell carcinoma and high preoperative FIB levels are more likely to have lower OS. It could be a clinical biomarker for the prognosis of laryngeal squamous cell carcinoma.

Key words: Laryngeal squamous cell carcinoma, Fibrinogen, Overall survival, Prognosis

CLC Number: 

  • R767
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