Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 41-45.doi: 10.6040/j.issn.1673-3770.0.2023.342

• Research Progress • Previous Articles     Next Articles

Advances in research on the relationship between obstructive sleep apnea and breast cancer

HU Tingting, WANG Yuehua   

  1. Department of oncology, Affiliated Hospital of Hubei University of Arts and Science Xiangyang Central Hospital, Xiangyang 441021, Hubei, China
  • Published:2023-12-15

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Abstract: Animal studies suggest that intermittent hypoxia due to obstructive sleep apnea(OSA)is a risk factor for breast cancer. Despite biological plausibility, human epidemiological studies have shown inconsistent results. However, a recent meta-analysis of seven large studies with a total of 5 370 466 patients showed that patients with OSA had a 36% increased risk of breast cancer compared to patients without OSA(HR 1.36, 95%CI 1.03-1.80). This article reviews the research on the relationship between OSA and breast cancer, including the possible pathogenesis of OSA-associated breast cancer.

Key words: Breast cancer, Hypoxia, Mechanism, Obstructive sleep apnea

CLC Number: 

  • R563.9
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