Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (2): 163-168.doi: 10.6040/j.issn.1673-3770.0.2023.333

• Review • Previous Articles    

Role of Toll-like receptor 4/nuclear transcription factor-κB channels in diabetic retinopathy

LUN Yingjun1, CHEN Chen2, GAO Hongcheng2, FAN Qinglin3, TAI Renqing1   

  1. 1. Department of Clinical Medical College, Weifang Medical College, Weifang 261000, Shandong, China2. Department of Ophthalmology, Linyi People's Hospital, Linyi 276000, Shandong, China3. Department of Postgraduate, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, Shandong, China
  • Online:2024-03-20 Published:2024-03-29

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Abstract: Diabetic retinopathy(DR)is a microvascular complication caused by diabetes mellitus and is the primary cause of blindness in patients. Its pathogenesis is influenced by various factors,such as immune inflammation, oxidative stress, and polyol pathways. Currently, immune-inflammatory responses are considered to play important roles in the development of DR. The Toll-like receptor 4(TLR4)/nuclear transcription factor-κB(NF-κB)pathway mediates the release of inflammatory factors and plays a key role in inflammatory mechanisms. Several studies have demonstrated that inhibition of the TLR4/NF-κB signaling pathway can effectively treat DR.This review addresses the role of TLR4/NF-κB channels in DR, which may provide novel treatment targets for this disease.

Key words: Diabetic retinopathy, Toll-like receptor 4, Nuclear factor kappa B, Microglia, Inflammation

CLC Number: 

  • R774.1
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