Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (3): 26-31.doi: 10.6040/j.issn.1673-3770.0.2024.120

• Shanghai Sixth Peoples Hospital Otorhinolaryngology & Head and Neck Surgery Department dedicated to “120th Anniversary of the Sixth Hospital” Commemorative Theme • Previous Articles    

Investigating the impact of serum bilirubin levels on the prognosis of patients with acute epiglottitis

SHEN Bojun, LIU Suru, LI Chunyan, SU Kaiming   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  • Published:2025-06-04

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Abstract: Objective To investigate the serum bilirubin levels in patients with acute epiglottitis and their impact on the prognosis of the disease. Methods This single-center retrospective case-control study included 105 patients diagnosed with acute epiglottitis and 52 patients with vocal cord nodules as the control group. General clinical data, hospitalization duration, bilirubin levels, and inflammatory markers were collected. Differences in bilirubin levels between the two groups were compared. Correlation analysis and multiple linear regression models were used to assess the associations between age, bilirubin levels, inflammatory markers, and the duration of hospital stay in patients with acute epiglottitis, and to further analyze the correlation between bilirubin and inflammatory markers. Results Upon admission, patients with acute epiglottitis had significantly higher bilirubin levels compared to the control group(P<0.001). Bilirubin levels decreased before discharge compared to at admission(P<0.001). Correlation analysis showed that the duration of hospital stay was negatively correlated with bilirubin levels at admission(P=0.030), and positively correlated with age, C-reactive protein, and white blood cell count(P<0.05). Multiple linear regression models indicated that bilirubin levels at admission were an independent factor influencing the duration of hospital stay(P=0.003). No linear correlation was found between admission bilirubin levels and systemic inflammatory markers such as white blood cell count, C-reactive protein, absolute neutrophil count, and absolute lymphocyte count(P>0.05). Conclusion Serum bilirubin levels are elevated in patients with acute epiglottitis, and bilirubin may serve as a potential risk assessment indicator for these patients.

Key words: Acute Epiglottitis, Bilirubin, Vocal Cord Nodule, C-reactive Protein, Leukocyte, Neu-trophil, Lymphocyte

CLC Number: 

  • R767.5
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