Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (2): 65-73.doi: 10.6040/j.issn.1673-3770.0.2024.283

• Original Article • Previous Articles     Next Articles

Meta-analysis of clinical effect of cyclosporine eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome

FANG Lu, LEI Yudan, WANG Hua   

  1. Optometry Center, The First Affiliated Hospital of Hunan Normal University/Hunan provincial People's Hospital, Changsha 410005, Hunan, China
  • Published:2026-03-26

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Abstract: Objective To study the clinical effect of cyclosporine eye drops combined with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A comprehensive Boolean logic retrieval approach was employed, and the literature retrieval databases included CNKI, Wanfang, PubMed, VIP, Web of Science, etc. The retrieval period spanned from the inception of each database until April 1, 2024. The quality assessment of the included literature was conducted using the Cochrane Risk of Bias Assessment Tool. For the meta-analysis, RevMan 5.3 software was utilized; mean deviation(MD)were calculated for continuous variables, while relative risks(RR)were computed for dichotomous variables with separate 5% confidence intervals. Results A total of 17 RCTs were included, and the quality evaluation of all the literatures was grade B. The tear film break-up time(BUT)was higher in the experimental group than that in the control group. There was high heterogeneity among the 17 study groups(I2=99%, P<0.000 01). After removing the literatures with relatively high bias, the result changed to moderate heterogeneity(I2=34%, P<0.000 01), and the differences were all statistically significant. Conclusion Cyclosporine eye drops combined with sodium hyaluronate eye drops have a good therapeutic effect on dry eye syndrome.

Key words: Cyclosporine, Sodium hyaluronate, Dry eye, Therapeutic effect, Meta-analysis

CLC Number: 

  • R777.2
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