Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (3): 36-41.doi: 10.6040/j.issn.1673-3770.1.2019.021

• Research Progress • Previous Articles     Next Articles

Current status of genetic research on allergic rhinitis

Meiping LU1(),Lei CHENG1,2   

  1. 1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University
    2. International Centre for Allergy Research, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2019-04-15 Revised:2019-05-01 Online:2019-05-20 Published:2019-08-08
  • Contact: Meiping LU E-mail:lmp@njmu.edu.cn

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Abstract:

Allergic rhinitis is a non-infectious inflammatory disease of the nasal mucosa caused by a combination of genetic and environmental factors. Although a fair understanding of its pathogenesis already exits and research on genetic factors associated with this condition has made significant progress, these studies are still limited to achieving statistically significant results; however, their clinical applications have a long way to go. This article mainly introduces the research strategy on genes related to allergic rhinitis, their interaction with the environment, the sharing overlap of allergic disease genes, epigenetic modifications, and the direction of gene research transformation.

Key words: Allergic rhinitis, Genes, Environment, Gene-environment interaction, Epigenetics, Precision medicine

CLC Number: 

  • R765.4
1 Brożek JL , Bousquet J , Agache I , et al . Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision[J]. J Allergy Clin Immunol, 2017,140(4): 950-958. doi:10.1016/j.jaci.2017.03.050 .
doi: 10.1016/j.jaci.2017.03.050
2 Wang XD , Zheng M , Lou HF , et al . An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011[J]. Allergy, 2016, 71(8): 1170-1180. doi:10.1111/all.12874 .
doi: 10.1111/all.12874
3 Sachidanandam R , Weissman D , Schmidt SC , et al . A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms[J]. Nature, 2001, 409(6822): 928-933. doi:10.1038/35057149 .
doi: 10.1038/35057149
4 Van Eerdewegh P , Little RD , Dupuis J , et al . Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness[J]. Nature, 2002, 418(6896): 426-430. doi:10.1038/nature00878 .
doi: 10.1038/nature00878
5 Ober C , Tan Z , Sun Y , et al . Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function[J]. N Engl J Med, 2008, 358(16): 1682-1691. doi:10.1056/NEJMoa0708801 .
doi: 10.1056/NEJMoa0708801
6 Allen M , Heinzmann A , Noguchi E , et al . Positional cloning of a novel gene influencing asthma from chromosome 2q14[J]. Nat Genet, 2003, 35(3): 258-263. doi:10.1038/ng1256 .
doi: 10.1038/ng1256
7 Nicolae D , Cox NJ , Lester LA , et al . Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21[J]. Am J Hum Genet, 2005, 76(2): 349-357. doi:10.1086/427763 .
doi: 10.1086/427763
8 Holloway JW , Yang IA , Holgate ST . Genetics of allergic disease[J]. J Allergy Clin Immunol, 2010, 125(2 Suppl 2): S81-S94. doi:10.1016/j.jaci.2009.10.071 .
doi: 10.1016/j.jaci.2009.10.071
9 Altshuler D , Daly MJ , Lander ES . Genetic mapping in human disease[J]. Science, 2008, 322(5903): 881-888. doi:10.1126/science.1156409 .
doi: 10.1126/science.1156409
10 McCarthy MI, Abecasis GR , Cardon LR , et al . Genome-wide association studies for complex traits: consensus, uncertainty and challenges[J]. Nat Rev Genet, 2008, 9(5): 356-369. doi:10.1038/nrg2344 .
doi: 10.1038/nrg2344
11 MacArthur J , Bowler E , Cerezo M , et al . The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)[J]. Nucleic Acids Res, 2017, 45(D1): D896-D901. doi:10.1093/nar/gkw1133 .
doi: 10.1093/nar/gkw1133
12 Li JY , Zhang Y , Zhang L . Discovering susceptibility genes for allergic rhinitis and allergy using a genome-wide association study strategy[J]. Curr Opin Allergy Clin Immunol, 2015, 15(1): 33-40. doi:10.1097/ACI.000-0000000000124 .
doi: 10.1097/ACI.000-0000000000124
13 Waage J , Standl M , Curtin JA , et al . Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis[J]. Nat Genet, 2018, 50(8): 1072-1080. doi:10.1038/s41588-018-0157-1 .
doi: 10.1038/s41588-018-0157-1
14 Huebner M , Kim DY , Ewart S , et al . Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort[J]. J Allergy Clin Immunol, 2008, 121(2): 408-414. doi:10.1016/j.jaci.2007.09.020 .
doi: 10.1016/j.jaci.2007.09.020
15 Holloway JW , Koppelman GH . Identifying novel genes contributing to asthma pathogenesis[J]. Curr Opin Allergy Clin Immunol, 2007, 7(1): 69-74. doi:10.1097/ACI.0b013e328013d51b .
doi: 10.1097/ACI.0b013e328013d51b
16 Yang IA , Savarimuthu S , Kim ST , et al . Gene-environmental interaction in asthma[J]. Curr Opin Allergy Clin Immunol, 2007, 7(1): 75-82. doi:10.1097/ACI.0b013 e328012ce39 .
doi: 10.1097/ACI.0b013 e328012ce39
17 London SJ , Romieu I . Gene by environment interaction in asthma[J]. Annu Rev Public Health, 2009, 30: 55-80. doi:10.1146/annurev.publhealth.031308.100151 .
doi: 10.1146/annurev.publhealth.031308.100151
18 Breton CV , Vora H , Salam MT , et al . Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function[J]. Am J Respir Crit Care Med, 2009, 179(7): 601-607. doi:10.1164/rccm.200809-1384OC .
doi: 10.1164/rccm.200809-1384OC
19 Palmer CN , Irvine AD , Terron-Kwiatkowski A , et al . Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis[J]. Nat Genet, 2006, 38(4): 441-446. doi:10.1038/ng1767 .
doi: 10.1038/ng1767
20 Smit LA , Siroux V , Bouzigon E , et al . CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults[J]. Am J Respir Crit Care Med, 2009, 179(5): 363-368. doi:10.1164/rccm.200810-1533OC .
doi: 10.1164/rccm.200810-1533OC
21 Chen HI , Lin YT , Jung CR , et al . Interaction between catalase gene promoter polymorphisms and indoor environmental exposure in childhood allergic rhinitis[J]. Epidemiology, 2017, 28(Suppl 1): S126-S132. doi:10.1097/EDE.0000000000000741 .
doi: 10.1097/EDE.0000000000000741
22 Rhodes HL , Thomas P , Sporik R , et al . A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status[J]. Am J Respir Crit Care Med, 2002, 165(2): 176-180. doi:10.1164/ajrccm. 165. 2.2104032 .
doi: 10.1164/ajrccm. 165. 2.2104032
23 Moffatt MF , Kabesch M , Liang LM , et al . Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma[J]. Nature, 2007, 448(7152): 470-473. doi:10.1038/nature06014 .
doi: 10.1038/nature06014
24 Tomita K , Sakashita M , Hirota T , et al . Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population[J]. Allergy, 2013, 68(1): 92-100. doi:10.1111/all.12066 .
doi: 10.1111/all.12066
25 Li XN , Howard TD , Zheng SL , et al . Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions[J]. J Allergy Clin Immunol, 2010, 125(2): 328-335.e11. doi:10.1016/j.jaci.2009.11.018 .
doi: 10.1016/j.jaci.2009.11.018
26 Kim WK , Kwon JW , Seo JH , et al . Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children[J]. J Allergy Clin Immunol, 2012, 130(2): 421-426.e5. doi:10.1016/j.jaci.2012.04.052 .
doi: 10.1016/j.jaci.2012.04.052
27 Lu MP , Chen RX , Wang ML , et al . Association study on IL4, IL13 and IL4RA polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population[J]. PLoS One, 2011, 6(11):e27363. doi： 10.1371/journal.pone.0095033 .
doi: 10.1371/journal.pone.0095033
28 Black S , Teixeira AS , Loh AX , et al . Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort[J]. Allergy, 2009, 64(8): 1172-1178. doi:10.1111/j.1398-9995.2009.01988.x .
doi: 10.1111/j.1398-9995.2009.01988.x
29 Esparza-Gordillo J , Weidinger S , Folster-Holst R , et al . A common variant on chromosome 11q13 is associated with atopic dermatitis[J]. Nat Genet, 2009,41(5):596-601. doi： 10.1038/ng.347 .
doi: 10.1038/ng.347
30 Potaczek DP , Harb H , Michel S , et al . Epigenetics and allergy: from basic mechanisms to clinical applications[J]. Epigenomics, 2017, 9(4): 539-571. doi:10.2217/epi-2016-0162 .
doi: 10.2217/epi-2016-0162
31 向荣，刘昀，许昱 . FOXP3甲基化在变应性鼻炎中的作用研究[J]. 临床耳鼻咽喉头颈外科杂志,2016,30(9):707-711. doi:10.13201/j.issn.1001-1781.2016.09.009
doi: 10.13201/j.issn.1001-1781.2016.09.009
XIANG Rong , LIU Yun , XU Yu . Effect of the FOXP3 gene methylation status in pathogenesis of patients with allergic rhinitis[J]. Journal Clinical Otorhinolaryngology Head Neck Surgery(China),2016, 30(9):707-711. doi:10.13201/j.issn.1001-1781.2016.09.009
doi: 10.13201/j.issn.1001-1781.2016.09.009
32 Yang IV , Pedersen BS , Liu AH , et al . The nasal methylome and childhood atopic asthma[J]. J Allergy Clin Immunol, 2017, 139(5): 1478-1488. doi:10.1016/j.jaci. 2016.07.036 .
doi: 10.1016/j.jaci. 2016.07.036
33 Nicodemus-Johnson J , Myers RA , Sakabe NJ , et al . DNA methylation in lung cells is associated with asthma endotypes and genetic risk[J]. JCI Insight, 2016, 1(20): e90151. doi:10.1172/jci.insight.90151 .
doi: 10.1172/jci.insight.90151
34 Nestor CE , Barrenäs F , Wang H , et al . DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure[J]. PLoS Genet, 2014, 10(1): e1004059. doi:10.1371/journal.pgen.1004059 .
doi: 10.1371/journal.pgen.1004059
35 Heffler E , Allegra A , Pioggia G , et al . MicroRNA profiling in asthma: potential biomarkers and therapeutic targets[J]. Am J Respir Cell Mol Biol, 2017, 57(6): 642-650. doi:10.1165/rcmb.2016-0231TR .
doi: 10.1165/rcmb.2016-0231TR
36 Panganiban RP , Pinkerton MH , Maru SY , et al . Differential microRNA epression in asthma and the role of miR-1248 in regulation of IL-5[J]. Am J Clin Exp Immunol, 2012, 1(2): 154-165.
37 Maes T , Cobos FA , Schleich F , et al . Asthma inflammatory phenotypes show differential microRNA expression in sputum[J]. J Allergy Clin Immunol, 2016, 137(5): 1433-1446. doi:10.1016/j.jaci.2016.02.018 .
doi: 10.1016/j.jaci.2016.02.018
38 Milger K , Götschke J , Krause L , et al . Identification of a plasma miRNA biomarker signature for allergic asthma: a translational approach[J]. Allergy, 2017, 72(12): 1962-1971. doi:10.1111/all.13205 .
doi: 10.1111/all.13205
39 Levänen B , Bhakta NR , Torregrosa Paredes P , et al . Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients[J]. J Allergy Clin Immunol, 2013, 131(3): 894-903. doi:10.1016/j.jaci. 2012. 11.039 .
doi: 10.1016/j.jaci. 2012. 11.039
40 Li YJ , Chen J , Rui XQ , et al . The association between sixteen genome-wide association studies-related allergic diseases loci and childhood allergic rhinitis in a Chinese Han population[J]. Cytokine, 2018, 111: 162-170. doi:10.1016/j.cyto.2018.08.022 .
doi: 10.1016/j.cyto.2018.08.022
41 Kersten ET , Koppelman GH . Pharmacogenetics of asthma: toward precision medicine[J]. Curr Opin Pulm Med, 2017, 23(1): 12-20. doi:10.1097/MCP.0000000000000335 .
doi: 10.1097/MCP.0000000000000335
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