Abstract: To explore the effect of nedocromil sodium on allergic rhinitis. Methods: Toluene 2,4 diisocyanate(TDI) was used to sensitize white rabbits as allergic rhinitis models, and nedocromil sodium was used to treat the disease. The changes in nasal mucosa were studied by pathological methods. Results: Symptoms of allergic rhinitis were remarkably relieved after nedocromil sodium treatment. Hematoxylin and eosin staining demonstrated that no edema was found in the nasal mucosa, and small vessels were normal after nedocromil sodium application; whereas edema, vasodilation and inflammatory cell infiltration were discovered in the control group. Conclusion: Nedocromil sodium has salutary effect on alleviating the symptom of nasal congestion, rhinorrhea and sneezing, and on reducing the sensory neuron sensitivity of the mucosa.

Key words: Allergic rhinitis, Nedocromil sodium, Pathology