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Influence of 18-βglycyrrhetinic acid on mitochondria of nasal mucosa epithelial cells in rats with allergic rhinitis

DONG Ming1, CHEN Xiao-wan1,2, XI Ke-hu1,2, WANG You-hu1,2, GUI Yan1,2, ZHANG Fu-hong1,2, MA Chun-xia1, HONG Hao1, LIU Xiang-yi2, JIANG Ying1, MA Yi1, YANG Gui-jun1, ZHANG Xiao-bing1,2.   

  1. Department of Otolaryngology, 1. First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China; 2. Affiliated Hospital of Gansu College of Traditional Chinese Medicine, Lanzhou 730020, Gansu, China
  • Received:2014-02-20 Online:2014-06-16 Published:2014-06-16

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Abstract: Objective    To observe the mitochondria dynamic changes of nasal mucosa epithelial cells in rats with allergic rhinitis and the influence of 18β- glycyrrhetinic acid on them. Methods    Ninety-six Wistar rats were randomly divided into 4 groups: the normal group， the model group， the loratadine group and the glycyrrhetinic acid group．AR models were established by ovalbumin and each group was respectively treated subsequently. After 2 weeks， 4 weeks， 6 weeks and 10 weeks，the ultrastructure changes were observed and compared. Results    Mitochondria in the model group showed that the number of Mitochondria increased， crest disappeared，  volume swelled or even cavitated and autophagy could be found. With persistent allergen exposure，the morphological changes aggravated gradually in the model group，meanwhile the changes in the glycyrrhetinic acid group(mentioned above in the model group)were improved and the mitochondria were much closer to the normal group with the extension of observation. Conclusion    Mitochondria ultrastructure changes of nasal mucosa ciliated epithelial cells in the rat with AR exacerbated gradually due to persistent exposure to allergen and 18β-glycyrrhetinic acid is effective to relieve the mitochondria ultrastructure changes.

Key words: -Glycyrrhetinic acid； Mitochondria, Rhinitis, allergic； 18&beta

CLC Number: 

  • R765.21
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