JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (5): 47-49.doi: 10.6040/j.issn.1673-3770.0.2015.150

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The relationship between D-Dimer and nasopharyngeal carcinoma

CHE Juan1, ZHAO Hongchun1, LI Jinling2, WANG Yanfei1   

  1. 1. Department of Otolaryngology, the Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China;
    2. Department of Laboratory Medicine, the Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China
  • Received:2015-04-09 Revised:2015-07-09 Online:2015-10-16 Published:2015-10-16

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Abstract: Objective To investigate the prognostic value of plasma D-dimer for nasopharyngeal carcinoma. Method Sixty-nine nasopharyngeal carcinoma patients and their gender-and age-matched healthy individuals were prospectively enrolled, and their plasma D-Dimer on admission were compared. The association between plasma D-Dimer and clinical stage of nasopharyngeal carcinoma was analyzed. The prognostic value of D-dimer for all-cause mortality was estimated by receiver operating characteristic (ROC) curves and Kaplan-Meier approach. Results Compared with healthy individuals, nasopharyngeal patients had significantly higher plasma D-dimer. Plasma D-Dimer increased as the advance of clinical stage of nasopharyngeal carcinoma. The area under ROC curve of plasma D-Dimer for all-cause mortality was 0.72. Patients with increased D-Dimer (more than 0.55 mg/L) have higher risk of death than the patients with normal D-Dimer (less than 0.55 mg/L). Conclusion D-Dimer is a useful prognostic factor for nasopharyngeal carcinoma. Increased D-Dimer is associated with poor prognosis.

Key words: D-Dimer, Prognosis, Nasopharyngeal carcinoma

CLC Number: 

  • R766.3
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