Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 124-127.doi: 10.6040/j.issn.1673-3770.0.2018.236

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Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function

DU Jingwei, FENG Jun, MA Peng, LI Zhiyong, LI Hongguang   

  1. Department of Otorhinolaryngology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong 637000, Sichuan, China
  • Online:2019-01-20 Published:2019-01-28

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Abstract: Objective To investigate the effects of nasal irrigation combined with glucocorticoid on exhaled nitric oxide(FeNO), pulmonary function, and quality of life in patients with allergic rhinitis(AR). Methods A total of 120 AR patients, admitted to our hospital from March 2016 to March 2017, were selected and randomly divided into the observation group and control group(n=60 cases, each). The control group was treated with budesonide spray(60 μg, once on each side)once every morning and evening for 3 months. The observation group was treated with saline irrigation(100 mL, once on each side)once every morning and evening, and then with budesonide nasal spray for 3 months. The FeNO, FVC%, FEV1%, PEF, VC%, and RQLQ scores were compared between the two groups. Results The levels of FeNO in the observation group and the control group were(750.2±89.4)×10-10mol/L and(816.3±92.7)×10-10mol/L, respectively, following treatment. There was a significant difference in the levels of FeNO between the two groups(t=-3.976, P<0.001). After treatment, the levels of FVC, FEV1%, PEF, and VC% in the observation group were higher than those in the control group(t=3.207, 4.211, 2.780, 3.272 and P=0.002, <0.001, 0.006, 0.001, respectively). The RQLQ scores of the observation group and the control group were(29.0±6.4)and(34.4±7.0), respectively, with a statistically significant difference(t=-4.410, P<0.001). Conclusion Nasal irrigation combined with nasal glucocorticoid therapy can reduce FeNO, and improve the pulmonary function and quality of life of AR patients to a certain extent.

Key words: Allergic rhinitis, Nasal irrigation, Nasal glucocorticoid, Exhaled nitric oxide, Pulmonary function

CLC Number: 

  • R765.21
[1] Bellanti JA, Settiane RA. Perspectives on allergic rhinitis and its treatment[J]. Allergy Asthma Proc, 2013, 34(6):485-487. doi:10.2500/aap.2013.34.0018.
[2] Zajac AE, Adams AS, Turner JH. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis[J]. Int Forum Allergy Rhinol, 2015, 5(6):524-532. doi:10.1002/alr.21492.
[3] 张继民,张冰,张燕霞,等.鼻用糖皮质激素对变应性鼻炎鼻黏膜中PLCε1表达的影响及意义[J].中国临床研究,2016,29(2):231-233. doi: 10.13429/j.cnki.cjcr.2016.02.024 ZHANG Jimin, ZHANG Bing, ZHANG Yanxia, et al. The effect and significance of intranasal glucocorticoid on the expression of PLC epsilon 1 in nasal mucosa of allergic rhinitis[J]. China Clinical Study, 2016,29(2):231-233. doi:10.13429/j.cnki.cjcr.2016.02.024
[4] 于玲. 鼻腔冲洗联合药物治疗婴幼儿变应性鼻炎的疗效分析[J]. 中国妇幼保健, 2017, 32(16):3986-3987. doi:10.7620/zgfybj.j.issn.1001-4411.2017.16.100.
[5] 杨笑染, 刘为民, 张淼, 等. 宁夏回族变应性鼻炎患者鼻腔冲洗治疗的临床观察[J]. 宁夏医学杂志, 2015, 37(2):148-150. doi:10.13621/j.1001-5949.2015.02.0148. YANG Xiaoran, LIU Weimin, ZHANGNIAO, et al. Clinical observation on nasal irrigation treatment in patients with allergic rhinitis[J]. Ningxia Medical Journal, 2015, 37(2):148-150. doi:10.13621/j.1001-5949.2015.02.0148.
[6] 林旸. 不同方法治疗变应性鼻炎的疗效观察[J]. 中国现代医药杂志, 2016,18(12):20-22. doi:10.3969/j.issn.1672-9463.2016.12.006. LIN Yang. Curative effect of allergic rhinitis treated by varied intervention[J]. Modern Medicine Journal of China, 2016, 18(12):20-22. doi:10.3969/j.issn.1672-9463.2016.12.006.
[7] Lierl MB. New developments in the treatment of pediatric allergic rhinitis and conjunctivitis[J]. Pediatr Ann, 2014, 43(8):e192-e200. doi:10.3928/00904481-20140723-09.
[8] Licari A, Ciprandi G, Marseglia A, et al. Current recommendations and emerging options for the treatment of allergic rhinitis[J]. Expert Rev Clin Immunol, 2014, 10(10):1337-1347. doi:10.1586/1744666X.2014.955476.
[9] Bernstein DI, Schwartz G, Bernstein JA. Allergic rhinitis: mechanisms and treatment[J]. Immunol Allergy Clin North Am, 2016, 36(2):261-278. doi:10.1016/j.iac.2015.12.004.
[10] 刘岷, 李彩霞, 张秋红. 罗红霉素联合丙酸氟替卡松鼻喷雾剂治疗变应性鼻炎的研究[J]. 中国民族民间医药, 2011, 20(15):10,12. doi:10.3969/j.issn.1007-8517.2011.15.008.
[11] 陈祖尧, 罗志葵, 朱发梅, 等. 糖皮质激素对变应性鼻炎豚鼠鼻黏膜嗜酸性粒细胞及肥大细胞浸润及P物质含量的影响[J]. 中南医学科学杂志, 2017, 45(2): 122-126. doi:10.15972/j.cnki.43-1509/r.2017.02.004. CHEN Zuyao, LUO Zhikui, ZHU Famei, et al. Effect of glucocorticoid on the infiltration of eosinophils, mast cells andSP in nasal mucosa of guinea pigs with allergic rhinitis[J]. Medical Science Journal of Central South China, 2017, 45(2):122-126. doi:10.15972/j.cnki.43-1509/r.2017.02.004.
[12] 吴杏梅, 许庚. 鼻用糖皮质激素联合鼻用抗组胺药在变应性鼻炎中的应用[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(2):170-172. doi:10.3760/cma.j.issn.1673-0860.2014.02.019.
[13] 徐才成, 曾玉芝, 章学军. 不同浓度盐水鼻腔冲洗治疗变应性鼻炎效果观察[J]. 白求恩医学杂志, 2017, 15(2):178-180. doi:10.16485/j.issn.2095-7858.2017.02.018.
[14] 史丽, 赵莉, 张红萍. 变应性鼻炎的长期抗炎治疗[J]. 山东大学耳鼻喉眼学报, 2017, 31(3):9-12. doi:10.6040/j.issn.1673-3770.0.2017.184. SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(3):9-12. doi:10.6040/j.issn.1673-3770.0.2017.184.
[15] 关凯, 李丽莎. 鼻腔冲洗在变应性鼻炎防治中的应用[J]. 山东大学耳鼻喉眼学报, 2017, 31(3):22-27. doi:10.6040/j.issn.1673-3770.0.2017.151. GUAN Kai, LI Lisha. Nasal irrigation and its role in the treatment of allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(3):22-27. doi:10.6040/j.issn.1673-3770.0.2017.151.
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