Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 9-12.doi: 10.6040/j.issn.1673-3770.1.2018.019

• Invited Review • Previous Articles     Next Articles

Research progress of group Ⅱ innate lymphoid cells in the allergic rhinitis

Yinshi GUO*(),Hui LU   

  1. Department of Allergy & Immunology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • Received:2017-10-08 Online:2019-01-20 Published:2019-01-28
  • Contact: Yinshi GUO E-mail:drguoyinshi@163.com
  • Supported by:
    2013国家临床重点专科建设项目;国家卫生计生委公益性行业科研专项(2015SQ00136)

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Abstract:

Allergic rhinitis (AR) is an allergic respiratory inflammation. T helper type 2 (Th2) cell activation plays an important role in the mediation of the disease. AR involves the innate and adaptive immune systems. Type 2 innate lymphoid cells (ILC2s) are considered the innate counterparts of Th2 cells based on the cytokines they express. Accumulating evidence has demonstrated that innate immune cells function as homeostatic regulators in the body. ILC2s contribute to the pathology of allergic inflammatory diseases. Here, we review the characteristics of ILC2s and progress of research on the mechanism of AR.

Key words: Allergic rhinitis, Type 2 T helper cells, Group Ⅱ innate lymphoid cells

CLC Number: 

  • R562
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