Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (3): 95-99.doi: 10.6040/j.issn.1673-3770.1.2019.015

• Original Article • Previous Articles     Next Articles

Analysis of malignant melanoma of the nasal cavity and paranasal sinuses in 23 cases

Jiacheng ZHANG,Liqing ZHANG(),Han ZHOU,Meiping LU,Wanyun XU,Yujie SHEN,Yaqin LIU,Min YIN,Weida DONG()   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2019-03-01 Revised:2019-05-03 Online:2019-05-20 Published:2019-08-07
  • Contact: Liqing ZHANG,Weida DONG E-mail:119835289@qq.com;weidadong2649@126.com

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Abstract: Objective

To explore the clinical features, diagnosis, treatment outcomes, and prognosis of patients with malignant melanoma of the nasal cavity and paranasal sinuses.

Methods

A retrospective review was performed of 23 patients with malignant melanoma of the nasal cavity and paranasal sinuses treated between October 2007 and September 2018.

Results

The average age of the 23 patients was 61.7 years. The proportions of men and women were similar. The tumors mostly occurred in the lateral wall of the nasal cavity and often involved the maxillary, frontal, and ethmoid sinuses. After treatment, the patients were followed-up for 6 months to 10 years. The 1-, 2-, 3-, and 5-year survival rates were 78.26% (18/23), 42.10% (8/19), 20% (3/15), and 11.11% (1/9), respectively.

Conclusion

The symptoms of malignant melanoma of the nasal cavity and sinuses are concealed and complex, with high degrees of malignancy and metastasis and extremely poor prognosis. The treatment strategy includes extensive surgical resection and postoperative individualized chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Early diagnosis and comprehensive treatment can significantly improve the survival rate of malignant melanoma.

Key words: Melanoma, Nasal cavity, Paranasal sinuses, Diagnosis, Prognosis, Surgical procedures, operative, Combined modality therapy

CLC Number: 

  • R765

Fig. 1

Clinical and pathological data of patient No. 1"

Fig.2

Clinical and pathological data of patient No. 2"

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