Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (3): 95-99.doi: 10.6040/j.issn.1673-3770.1.2019.015

• Original Article • Previous Articles     Next Articles

Analysis of malignant melanoma of the nasal cavity and paranasal sinuses in 23 cases

Jiacheng ZHANG,Liqing ZHANG(),Han ZHOU,Meiping LU,Wanyun XU,Yujie SHEN,Yaqin LIU,Min YIN,Weida DONG()   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2019-03-01 Revised:2019-05-03 Online:2019-05-20 Published:2019-08-07
  • Contact: Liqing ZHANG,Weida DONG E-mail:119835289@qq.com;weidadong2649@126.com

RichHTML

12

PDF (PC)

459

Abstract: Objective

To explore the clinical features, diagnosis, treatment outcomes, and prognosis of patients with malignant melanoma of the nasal cavity and paranasal sinuses.

Methods

A retrospective review was performed of 23 patients with malignant melanoma of the nasal cavity and paranasal sinuses treated between October 2007 and September 2018.

Results

The average age of the 23 patients was 61.7 years. The proportions of men and women were similar. The tumors mostly occurred in the lateral wall of the nasal cavity and often involved the maxillary, frontal, and ethmoid sinuses. After treatment, the patients were followed-up for 6 months to 10 years. The 1-, 2-, 3-, and 5-year survival rates were 78.26% (18/23), 42.10% (8/19), 20% (3/15), and 11.11% (1/9), respectively.

Conclusion

The symptoms of malignant melanoma of the nasal cavity and sinuses are concealed and complex, with high degrees of malignancy and metastasis and extremely poor prognosis. The treatment strategy includes extensive surgical resection and postoperative individualized chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Early diagnosis and comprehensive treatment can significantly improve the survival rate of malignant melanoma.

Key words: Melanoma, Nasal cavity, Paranasal sinuses, Diagnosis, Prognosis, Surgical procedures, operative, Combined modality therapy

CLC Number: 

  • R765

Fig. 1

Clinical and pathological data of patient No. 1"

Fig.2

Clinical and pathological data of patient No. 2"

1 KellerDS, ThomayAA, GaughanJ, et al. Outcomes in patients with mucosal melanomas[J]. J Surg Oncol, 2013, 108(8): 516-520. doi:10.1002/jso.23445.
doi: 10.1002/jso.23445
2 GavrielH, McArthurG, SizelandA, et al. Review: mucosal melanoma of the head and neck[J]. Melanoma Res, 2011, 21(4): 257-266. doi:10.1097/cmr.0b013-e328-3470ffd.
doi: 10.1097/cmr.0b013-e328-3470ffd
3 LindsayCR, SpiliopoulouP, WaterstonA. Blinded by the light: why the treatment of metastatic melanoma has created a new paradigm for the management of cancer[J]. Ther Adv Med Oncol, 2015, 7(2): 107-121. doi:10.1177/1758834014566619.
doi: 10.1177/1758834014566619
4 MedinaJE, FerlitoA, PellitteriPK, et al. Current management of mucosal melanoma of the head and neck[J]. J Surg Oncol, 2003, 83(2): 116-122. doi:10.1002/jso.10247.
doi: 10.1002/jso.10247
5 BatsakisJG, SuarezP. Mucosal melanomas: a review[J]. Adv Anat Pathol, 2000, 7(3): 167-180.doi:10.1097/00125480-200007030-00006
doi: 10.1097/00125480-200007030-00006
6 ZhuZQ, LiuW, GotliebV. The rapidly evolving therapies for advanced melanoma: towards immunotherapy, molecular targeted therapy, and beyond[J]. Crit Rev Oncol Hematol, 2016, 99: 91-99. doi:10.1016/j.critrevonc. 2015.12.002.
doi: 10.1016/j.critrevonc. 2015.12.002
7 LourençoSV, FernandesJD, HsiehR, et al. Head and neck mucosal melanoma: a review[J]. Am J Dermatopathol, 2014, 36(7): 578-587. doi:10.1097/DAD.00000000-00000035.
doi: 10.1097/DAD.00000000-00000035
8 王梦君. 鼻腔鼻窦恶性黑色素瘤的临床诊疗进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(2): 116-120. doi:10.6040/j.issn.1673-3770.0.2016.293.
doi: 10.6040/j.issn.1673-3770.0.2016.293
WANGMengjun. Advances in clinical diagnosis and treatment of sinonasal mucosal malignant melanoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(2): 116-120. doi:10.6040/j.issn.1673-3770.0.2016.293.
doi: 10.6040/j.issn.1673-3770.0.2016.293
9 BacharG, LohKS, O′SullivanB, et al. Mucosal melanomas of the head and neck: experience of the Princess Margaret Hospital[J]. Head Neck, 2008, 30(10): 1325-1331. doi:10.1002/hed.20878.
doi: 10.1002/hed.20878
10 周兵, 王洁, 王晨亮. 原发性鼻腔黏膜恶性黑色素瘤6例临床病理分析并文献复习[J]. 临床与实验病理学杂志, 2015, 31(5): 587-588,589. doi:10.13315/j.cnki.cjcep.2015.05.027.
doi: 10.13315/j.cnki.cjcep.2015.05.027
11 刘雯, 曾智, 周亨, 等. 原发性鼻黏膜恶性黑色素瘤17例临床病理分析[J]. 临床与实验病理学杂志, 2017, 33(2): 169-173. doi:10.13315/j.cnki.cjcep.2017.02.012.
doi: 10.13315/j.cnki.cjcep.2017.02.012
LIUWen, ZENGZhi, ZHOUHeng, et al. Primary mucosal melanoma of the nasal cavity: a linicopathological analysis of 17 cases[J]. Chinese Journal of Clinical and Experimental Pathology, 2017, 33(2): 169-173. doi:10.13315/j.cnki.cjcep.2017.02.012.
doi: 10.13315/j.cnki.cjcep.2017.02.012
12 杨娜, 张佳, 孙克巍. 鼻腔恶性黑色素瘤的确诊及治疗分析[J]. 中国耳鼻咽喉头颈外科, 2016, 23(4): 237-238. doi:10.16066/j.1672-7002.2016.04.014.
doi: 10.16066/j.1672-7002.2016.04.014
13 吴云腾, 任国欣, 孙沫逸, 等. 中国头颈黏膜黑色素瘤临床诊治专家共识[J]. 中国口腔颌面外科杂志, 2015, 13(3): 262-269.
WUYunteng, RENGuoxin, SUNMoyi, et al. Chinese expert consensus document on head and neck mucosal malignant melanoma[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(3): 262-269.
14 MatinRN, ChikhA, ChongSL, et al. p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis[J]. J Exp Med, 2013, 210(3): 581-603. doi:10.1084/jem.20121439.
doi: 10.1084/jem.20121439
15 徐婧雯, 蒋惠慈, 陈汐敏, 等. 抗体药物治疗黑色素瘤的现状及进展[J]. 中国药科大学学报, 2014, 45(3): 259-266. doi:10.11665/j.issn.1000-5048.20140302.
doi: 10.11665/j.issn.1000-5048.20140302
XUJingwen, JIANGHuici, CHENXimin, et al. Advances in antibody drugs for treatment of melanoma[J]. Journal of China Pharmaceutical University, 2014, 45(3): 259-266. doi:10.11665/j.issn.1000-5048.20140302.
doi: 10.11665/j.issn.1000-5048.20140302
16 McDermottDF, AtkinsMB. PD-1 as a potential target in cancer therapy[J]. Cancer Med, 2013, 2(5): 662-673. doi:10.1002/cam4.106.
doi: 10.1002/cam4.106
17 SwaikaA, HammondWA, JosephRW. Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy[J]. Mol Immunol, 2015, 67(2 Pt A): 4-17. doi:10.1016/j.molimm.2015.02.009.
doi: 10.1016/j.molimm.2015.02.009
[1] SUN Xiaohan, LI Na. Application of laryngeal retention strategy in the treatment of laryngeal cancer - introduction to the clinical practice guide of the American Society of Clinical Oncology(2017) [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 40-42.
[2] HUANG He, OUYANG Hui. Risk factors and prognosis of esophageal cancer with hypopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 82-86.
[3] YAN Zhigang, ZHANG Huihui, YU Dan, LIU Yan, WEN Lianji, WANG Di. Diagnosis and treatment of cognitive deficits in adult patients with obstructive sleep apnea hypopnea syndrome [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 155-161.
[4] Qing ZHAO,Han ZHOU,Min YIN,Jian FENG,Jiacheng ZHANG,Yaqin LIU,Yujie SHEN,Ziping LIN,Weida DONG. Value of preoperative hyperselective vascular embolization in juvenile nasopharyngeal angiofibroma treatment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 100-105.
[5] Huijun CHEN,Shenghua SONG,Han ZHOU,Weida DONG,Mingzhe QIAO,Xi CHEN,Jin XU,Ziping LIN,Guangqian XING. Preoperative platelet-lymphocyte ratio is an independent prognostic factor for laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 106-110.
[6] Jian FENG,Han ZHOU,Weida DONG. Advances in endoscopic diagnosis of laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 129-133.
[7] Xiaolu LI. Differential diagnosis of vestibular migraines and several common types of peripheral vertigo [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 23-26.
[8] WANG Yue, LIU Qian, WANG Haibo. Prospect and progress of spontaneous cerebrospinal fluid otorrhea [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 130-135.
[9] Kai GUAN,Lianglu WANG. Overall diagnosis and treatment strategy for allergic diseases related to hay fever [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 13-19.
[10] Chuanhe LIU. The prevalence, diagnosis and management of asthma in children in China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 28-32.
[11] CHEN Lixiao, JIANG Rui, YU Ziwei. Narrow-band imaging in diagnosis and treatment of tumors of the pharynx and larynx [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 104-108.
[12] ZHANG Jingyi, WANG Wenyi, ZHANG Qingquan. A case of mucosa-associated lymphoid tissue lymphoma initiating in conjunctiva [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 121-122.
[13] ZHANG Ruxiang, TIAN Hao, MA Youxiang. Computed tomography assessment of skull base height before endoscopic sinus surgery [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 75-77.
[14] ZHU Mingjuan, XING Kai, KANG Zefeng, LIU Jian. Diagnosis and treatment of thyroid-associated ophthalmopathy [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 110-113.
[15] ZHONG Jianwen, LIU Dabo, LUO Xiangqian, HUANG Zhenyun, QIU Shuyao, CHENG Chao, YANG Liqiang, YI Xinhua, ZENG Jinhong. The application of wearable devices in the diagnosis of children obstructive sleep apnea [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 30-33.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 84 -87 .
[3] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 90 -91 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 200 -203 .
[5] BAI Guang-ping,LI Jun,DONG Pin . Endscopic surgery for chronic nasosinusitis and nasal polyps in 180 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 242 -243 .
[6] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 285 -285 .
[7] ZHANG Ji-zhong,LI Da-jian . Chondroseptum or ethmoid in repairing of nasal septum perforation under endoscopy[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 336 -337 .
[8]

YU De-xian,ZHANG Wen-shan,PI Shi-jun,CAO Gui-xia,LI Yong-qiang,MA Qing,HUANG Jian

. Oil gauze of traditional Chinese medicine for nasal packing after functional endoscopic sinus surgery[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 340 -342 .
[9] WEI Li-ping,LIU Hong-ying,XU Zhao-xia . Effect of trans-nasal endoscopic sinus surgery on chronic sinusitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 345 -346 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 349 -349 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd