Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 195-201.doi: 10.6040/j.issn.1673-3770.0. 2020.477

Previous Articles     Next Articles

Effects of three different nasal uses of glucocorticoid on mucosal outcome after endoscopic sinus surgery

CHEN Shiqin, WEI Pingcun, HU Yunlong, HU Jinwang   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Anhui No.2 Provincial People's Hospital, Hefei 230041, Anhui, China
  • Published:2022-06-15

PDF (PC)

210

Abstract: Objective To study the effects of three different glucocorticoid administration methods on nasal mucosal outcome after endoscopic sinus surgery for chronic rhinosinusitis patients. Methods 60 patients who with chronic rhinosinusitis after endoscopic surgery were randomly divided into three groups, 20 patients cavities in each group. Respectively nasopore filled in surgical cavity and conventional hormone nasal spray(Group A), nasopore with budesonide suspension liquid filled and conventional hormone nasal spray(Group B), nasopore filled and hormone nasal spray at the head back position(Group C). Comparing nasal symptoms improvement and mucous membrane outcome between groups of patients. Results Visual analogue scale(VAS)and Lund-Kennedy scores of nasal endoscopy in group B and group C were lower than those in group A at the 2, 4 and 12 weeks after surgery(P<0.05). The rates of nasal vesicles, edema, secretion and scab in group B and group C were lower than those in group A at 2, 4 and 12 weeks after operation(P<0.05). The nasal scar adhesion rate of group B and group C were lower than those in group A at 4 and 12 weeks after surgery(P<0.05). At 4 and 12 weeks after surgery, VAS and Lund-Kennedy scores in group C were lower than those in group B(P<0.05). The incidence of nasal edema and secretions in group C were lower than those in group B at 12 weeks after operation(P<0.05). Conclusion The two methods of nasopore with budesonide suspension liquid filled in the nasal cavity joint with conventional hormone nasal spray,and nasopore filled joint with the hormone spray at the head back position after the operation play an active role after endoscopic surgery for chronic rhinosinusitis. They can relieving patients'symptoms, repairing and remodeling the mucous membrane in the operative cavity. And the effect of the hormone spray at the head back position is better.

Key words: Glucocorticoid, Chronic rhinosinusitis, Endoscopic sinus surgery, Mucous membrane, Visual analogue scale, Nasal endoscopic Lund-Kennedy scale

CLC Number: 

  • R765.4
[1] Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(Suppl S29): 1-464. doi:10.4193/Rhin20.600.
[2] 杨钦泰, 孙悦奇, 吴庆武, 等. 2020年欧洲鼻窦炎和鼻息肉意见书解读[J]. 中华耳鼻咽喉头颈外科杂志, 2020, 55(3): 304-308. doi:10.3760/cma.j.issn.1673-0860.2020.03.024. YANG Qintai, SUN Yueqi, WU Qingwu, et al. Interpretation of 2020 European position paper on rhinosinusitis and nasal polyps[J]. Chin J Otorhinolaryngol Head Neck Surg, 2020, 55(3): 304-308. doi:10.3760/cma.j.issn.1673-0860.2020.03.024.
[3] 付清玲, 史剑波. 我国慢性鼻-鼻窦炎的流行病学特征及其伴随疾病和危险因素解析[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(5): 321-324. doi:10.13201/j.issn.1001-1781.2018.05.001. FU Qingling, SHI Jianbo. Epidemiology, occupational and environmental risk factors of chronic rhinosinusitis in China[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(5): 321-324.doi:10.13201/j.issn.1001-1781.2018.05.001.
[4] 李晓华, 詹志荣, 孙建设, 等. 布地奈德对不伴鼻息肉的慢性鼻-鼻窦炎术后鼻黏膜细胞外基质的影响[J]. 中国耳鼻咽喉头颈外科, 2014,21(10): 546-549. doi:10.16066/j.1672-7002.2014.10.029. LI Xiaohua, ZHAN Zhirong, SUN Jianshe, et al. Effects of budesonide on extracellular matrix in nasal mucosa of chronic rhinosinusitis without nasal polyps after endoscopic sinus surgery[J]. Chin Arch Otolaryngol-Head Neck Surg, 2014,21(10): 546-549. doi:10.16066/j.1672-7002.2014.10.029.
[5] 徐翔, 葛亮, 刘蓓, 等. 鼻内镜术后鱼腥草滴鼻液与糠酸莫米松鼻喷雾剂联合局部应用对鼻黏膜组织重塑的影响研究[J]. 中国耳鼻咽喉头颈外科, 2020, 27(1): 43-46. doi:10.16066/j.1672-7002.2020.01.012.
[6] Snidvongs K, Pratt E, Chin D, et al. Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2012, 2(5): 415-421. doi:10.1002/alr.21047.
[7] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 中国慢性鼻窦炎诊断和治疗指南(2018)[J]. 中华耳鼻咽喉头颈外科杂志, 2019, 54(2): 81-100. doi:10.3760/cma.j.issn.1673-0860.2019.02.001.
[8] 陈晓栋, 王海婷, 石照辉, 等. 慢性鼻-鼻窦炎内镜手术应用布地奈德混悬液中鼻道浸润的长期疗效观察[J]. 临床耳鼻咽喉头颈外科杂志, 2016,30(3): 203-205,208. doi:10.13201/j.issn.1001-1781.2016.03.008. CHEN Xiaodong, WANG Haiting, SHI Zhaohui, et al. Long-term outcome of budesonide middle meatus treatment for chronic rhinosinusitis patients following endoscopic sinus surgery[J]. J Clin Otorhinolaryngol Head Neck Surg, 2016, 30(3): 203-205,208. doi:10.13201/j.issn.1001-1781.2016.03.008.
[9] 李华斌, 赖玉婷. 慢性鼻-鼻窦炎的发病机制及诊疗进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 4-9. doi: 10.6040/j.issn.1673-3770.1.2018.004. LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 4-9. doi: 10.6040/j.issn.1673-3770.1.2018.004.
[10] 谭国林. 从慢性鼻-鼻窦炎鼻息肉的发病机制认识鼻内镜手术后的高复发率[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(5): 324-327. doi:10.13201/j.issn.1001-1781.2018.05.002. TAN Guolin. Mechanism of chronic rhinosinusitis with polyps and its association with high recurrence rate of polyps after sinus surgery[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(5): 324-327.doi:10.13201/j.issn.1001-1781.2018.05.002.
[11] Rezaeian A. Outcome of spray cryotherapy plus functional endoscopic sinus surgery on management of healing in nasal polyposis[J]. Am J Otolaryngol, 2018, 39(1): 10-13.doi:10.1016/j.amjoto.2017.10.007.
[12] Hwang CS, Al Sharhan SS, Kim BR, et al. Randomized controlled trial of steroid-soaked absorbable calcium alginate nasal packing following endoscopic sinus surgery[J]. Laryngoscope, 2018, 128(2): 311-316. doi:10.1002/lary.26871.
[13] Xu JJ, Busato GM, McKnight C, et al. Absorbable steroid-impregnated spacer after endoscopic sinus surgery to reduce synechiae formation[J]. Ann Otol Rhinol Laryngol, 2016, 125(3): 195-198. doi:10.1177/0003489415606446.
[14] Levy JM, Mace JC, DeConde AS, et al. Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2016, 6(9): 906-913. doi:10.1002/alr.21776.
[15] 王建强, 白东风, 田春艳, 等. 三种填塞材料在鼻内镜术后填塞中的临床效果分析[J]. 中国耳鼻咽喉头颈外科, 2019, 26(11): 624-625. doi:10.16066/j.1672-7002.2019.11.013.
[16] 许海波, 洪燕丽, 李兆生, 等. 鼻内镜术后不同填塞材料对术后黏膜转归的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 85-87,91. XU Haibo, HONG Yanli, LI Zhaosheng, et al. Packing material on outcomes of sinus mucosa with chronic rhinosinusitis after endoscopic sinus surgery[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(5): 85-87,91.
[17] Chandra RK, Conley DB, Haines GK, et al. Long-term effects of FloSealTM packing after endoscopic sinus surgery[J]. Am J Rhinol, 2005, 19(3): 240-243. doi:10.1177/194589240501900304.
[18] Tajudeen BA, Ganti A, Kuhar HN, et al. The presence of eosinophil aggregates correlates with increased postoperative prednisone requirement[J]. Laryngoscope, 2019, 129(4): 794-799. doi:10.1002/lary.27693.
[19] Poetker DM, Jakubowski LA, Lal D, et al. Oral corticosteroids in the management of adult chronic rhinosinusitis with and without nasal polyps: an evidence-based review with recommendations[J]. Int Forum Allergy Rhinol, 2013, 3(2): 104-120. doi:10.1002/alr.21072.
[20] Marple BF, Smith TL, Han JK, et al. Advance II: a prospective, randomized study assessing safety and efficacy of bioabsorbable steroid-releasing sinus implants[J]. Otolaryngol Head Neck Surg, 2012, 146(6): 1004-1011. doi:10.1177/0194599811435968.
[21] Hox V, Lourijsen E, Jordens A, et al. Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper[J]. Clin Transl Allergy, 2020, 10: 1.doi:10.1186/s13601-019-0303-6.
[22] 岑瑞祥, 许昱, 万浪, 等. 纳吸棉联合布地奈德混悬液在内镜鼻窦术后填塞中的应用[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(23): 1835-1838. doi:10.13201/j.issn.1001-1781.2014.23.005. CEN Ruixiang, XU Yu, WAN Lang, et al. Application of nasopore and budesonide suspension on tamping after endoscopic sinus surgery[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2014, 28(23): 1835-1838. doi:10.13201/j.issn.1001-1781.2014.23.005.
[23] 许庚, 李源, 谢民强, 等. 功能性内窥镜鼻窦手术后术腔粘膜转归阶段的划分及处理原则[J]. 中华耳鼻咽喉科杂志, 1999,34(5):302-305. XU Geng, LI Yuan, XIE Minqiang, et al. Staging of mucous membrane outcome in operative cavity after functional endoscopic sinus surgery[J]. Chin J Otorhinolaryngol, 1999, 34(5):302-305.
[1] AO Tian,CHENG Lei. An endotype study of chronic rhinosinusitis with nasal polyps and precise control and treatment under the guidance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 7-14.
[2] YAO Shuang,LOU Hongfei. Advances in endotypes and precision medicine in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 20-29.
[3] SHI Shuai, ZHENG Quan,CHENG Lei. Research advances of dupilumab in the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 36-42.
[4] WANG Huan, HU Li,YU Hongmeng. Research progress of olfactory dysfunction in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 43-49.
[5] YI Ruonan,CHEN Fuquan. Eosinophils and Olfactory Dysfunction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 50-55.
[6] GU Yu, WAN Xin,XIAO Zi'an. The interaction between neutrophils and eosinophils in chronic rhinosinusitis and the implications on treatment options [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 56-63.
[7] LIN Hai, ZHU Ying,ZHANG Weitian. The roles of ion channels in the pathogenesis of chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 64-70.
[8] QIAO Xinjie,. Research progress on the signal transduction pathway and other factors related to epithelial-mesenchymal transformation in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 71-77.
[9] HUANG Danyi, ZHANG Ting,CHEN Jing, ZHANG Wei. Progress of research regarding the role of the epithelial barrier in chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 78-83.
[10] LI Jiani, ZHU Dongdong,MENG Cuida. The role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 84-91.
[11] CAO Xuan,XIAO Xuping, LI Yunqiu. Advances in the application of hyaluronic acid in chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 104-109.
[12] WANG Na,CHAI Xiangbin. Research progress on prostate-derived ETS factor in asthma and inflammatory diseases of the nasal mucosa [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 136-141.
[13] LIU Yitong, ZHOU Suizi,QIU Qianhui. Research progress on NLRP3 inflammasome in chronic rhinosinusitis and allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 142-146.
[14] QIN Ming, SUN Zhanwei, WANG Weiwei, LI Shichao, WU Tianyi, WANG Guangke. Efficacy of alkaline isotonic saline in laryngopharyngeal reflux symptom-positive or finding score-positive patients with chronic rhinosinusitis following endoscopic sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 147-153.
[15] LI Lin, GAO Zhengwen, CUI Nan, SUN Jianping, HUANG Xianming, CUI Jing. Bioinformatics analysis of gene expression profile in pediatric patients with chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 171-180.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] MA Bao-feng,DANG Guang-fu .

Trans-scleral suture fixation in implantation of foldable intraocular lenses

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 376 -378 .
[2] FENG Xin-rong,ZHANG Hong-xia,XU Zhen-ji,QU Jun-jun, . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(3): 225 -226 .
[3] ZHANG Qiu-gui,HE Hai-yan . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 520 -521 .
[4] LI Hai-yan,ZHAO Qiu-liang,HAN Xiao-pan,YU li . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 527 -529 .
[5] SONG Xi-cheng,ZHANG hua,ZHANG Qing-quan . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(5): 385 -387 .
[6] ZHAN Shan-qiang,KONG Fan-li,CAO Wen-juan,TANG Jie . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 559 -560 .
[7] ZHANG Hu,AI Qin . Re-operation for thyroid cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(2): 166 -167 .
[8] HU Ming,LI Zhao-na,LI Yun-jie ,TAO Xiang-chen . Effect of rigid gas permeable contact lens on keratoconus[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(2): 171 -173 .
[9] LOU Feng . Effect of bilateral superior laryngeal nerve block on preventing cardiovascular reaction[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 173 -175 .
[10] CHEN Wei-Xiong, WANG Yue-Jian, CENG Yong, HE Fa-Yao, ZHANG Jian-Li, ZHENG Li-Gang, TANG Su-Cheng. Clinical experience of no-insufflation endoscopic thyroidectomy by a small incision upon the sternum[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(4): 24 -26 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd