Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (5): 26-33.doi: 10.6040/j.issn.1673-3770.0.2023.325

• Original Article • Previous Articles    

Meta-analysis of the efficacy of omalizumab in combination with specific immunotherapy for allergic rhinitis

XU Xuemeng1, FAN Lei1, YU Wangbo1, JIANG Zhiyue2, PAN Chen1, HUANG Yongqin1   

  1. 1. Department of Otorhinolaryngology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637002, Sichuan, China2. Guizhou University of Medical Sciences, Guiyang 550004, Guizhou, China
  • Published:2025-09-19

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Abstract: Objective To examine the disparity in effectiveness between the combination therapy of omalizumab with specific immunotherapy and specific immunotherapy alone, aiming to furnish insights for the clinical management of allergic rhinitis. Methods Computerized searches were performed using CNKI, Pubmed, SinoMed, Embase, and Cochrane, with the start and end of the literature search from the period of establishment of the database to June 2023, respectively. Data were extracted after screening the literature according to inclusion criteria and performing a rigorous quality evaluation of the included literature; meta-analysis was performed by applying R 4.3.1 software. Results Five randomized controlled studies with 445 patients were included. 223 cases of patients treated with omalizumab combined with specific immunotherapy and 222 cases of those treated with specific immunotherapy alone were analyzed. Meta-analysis showed that the severity score and use of rescue medication score were reduced in patients treated with omalizumab combined with specific immunotherapy compared to those treated with specific immunotherapy alone(P<0.001); however, differences in the scores of adverse effects between the two groups were not statistically significant(P=0.52). Conclusion Existing evidence indicates that combining omalizumab with specific immunotherapy offers superior control over clinical symptoms and reduces the need for palliative medications compared to specific immunotherapy alone in patients with allergic rhinitis. However, further confirmation through large-sample, multicentric, double-blind randomized controlled trials is warranted in the future.

Key words: Allergic rhinitis, Specific immunotherapy, Omalizumab, Meta-analysis

CLC Number: 

  • R765
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