JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (2): 40-45.doi: 10.6040/j.issn.1673-3770.0.2015.473

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Expressions and significance of TNF-α and IL-8 in serum and peripheral blood mononuclear cells from patients with sudden sensorineural hearing loss.

HENG Weiwei1,2, HOU Jie1, WEI Xianmei1, SHE Wandong1   

  1. 1. Department of Otolaryngology &Head and Neck Surgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Nanjing 210008, Jiangsu, China;2. Department of Otolaryngology &Head and Neck Surgery, Nanjing Stomatological Hospital, Medical College of Nanjing University, Nanjing 210008, Jiangsu, China
  • Received:2015-11-09 Online:2016-04-16 Published:2016-04-16

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Abstract: Objective To explore the expressions of tumor necrosis factor-α(TNF-α)and intedeukik-8(IL-8)in serum and peripheral blood mononuclear cells(PBMCs)from patients with sudden sensorineural hearing loss(SSNHL)and their clinical significance. Methods A total of 44 patients with SSNHL and 32 age-matched controls were enrolled in the study. The expressions of TNF-α and IL-8 in the serum and PBMCs were detected respectively. Results The expressions of TNF-α and IL-8 in the serum from patients with SSNHL were not much different from those in normal controls(P>0.05). However, they were significantly higher in PBMCs(P<0.05). Conclusion The elevated expressions of TNF-α and IL-8 in patients with SSNHL are closely related to the inner ear immune-mediation, indicating that inflammation may play an important role in the pathogenesis of the disease. The expressions of TNF-α and IL-8 may serve as novel diagnostic and therapeutic targets of SSNHL.

Key words: IL-8, Sudden sensorineural hearing loss, Inflammation, TNF-α, Immune-mediated, Serum, Peripheral blood mononuclear cell

CLC Number: 

  • R764.4
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