Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 124-127.doi: 10.6040/j.issn.1673-3770.0.2018.236

Previous Articles     Next Articles

Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function

DU Jingwei, FENG Jun, MA Peng, LI Zhiyong, LI Hongguang   

  1. Department of Otorhinolaryngology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong 637000, Sichuan, China
  • Online:2019-01-20 Published:2019-01-28

PDF (PC)

195

Abstract: Objective To investigate the effects of nasal irrigation combined with glucocorticoid on exhaled nitric oxide(FeNO), pulmonary function, and quality of life in patients with allergic rhinitis(AR). Methods A total of 120 AR patients, admitted to our hospital from March 2016 to March 2017, were selected and randomly divided into the observation group and control group(n=60 cases, each). The control group was treated with budesonide spray(60 μg, once on each side)once every morning and evening for 3 months. The observation group was treated with saline irrigation(100 mL, once on each side)once every morning and evening, and then with budesonide nasal spray for 3 months. The FeNO, FVC%, FEV1%, PEF, VC%, and RQLQ scores were compared between the two groups. Results The levels of FeNO in the observation group and the control group were(750.2±89.4)×10-10mol/L and(816.3±92.7)×10-10mol/L, respectively, following treatment. There was a significant difference in the levels of FeNO between the two groups(t=-3.976, P<0.001). After treatment, the levels of FVC, FEV1%, PEF, and VC% in the observation group were higher than those in the control group(t=3.207, 4.211, 2.780, 3.272 and P=0.002, <0.001, 0.006, 0.001, respectively). The RQLQ scores of the observation group and the control group were(29.0±6.4)and(34.4±7.0), respectively, with a statistically significant difference(t=-4.410, P<0.001). Conclusion Nasal irrigation combined with nasal glucocorticoid therapy can reduce FeNO, and improve the pulmonary function and quality of life of AR patients to a certain extent.

Key words: Allergic rhinitis, Nasal irrigation, Nasal glucocorticoid, Exhaled nitric oxide, Pulmonary function

CLC Number: 

  • R765.21
[1] Bellanti JA, Settiane RA. Perspectives on allergic rhinitis and its treatment[J]. Allergy Asthma Proc, 2013, 34(6):485-487. doi:10.2500/aap.2013.34.0018.
[2] Zajac AE, Adams AS, Turner JH. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis[J]. Int Forum Allergy Rhinol, 2015, 5(6):524-532. doi:10.1002/alr.21492.
[3] 张继民,张冰,张燕霞,等.鼻用糖皮质激素对变应性鼻炎鼻黏膜中PLCε1表达的影响及意义[J].中国临床研究,2016,29(2):231-233. doi: 10.13429/j.cnki.cjcr.2016.02.024 ZHANG Jimin, ZHANG Bing, ZHANG Yanxia, et al. The effect and significance of intranasal glucocorticoid on the expression of PLC epsilon 1 in nasal mucosa of allergic rhinitis[J]. China Clinical Study, 2016,29(2):231-233. doi:10.13429/j.cnki.cjcr.2016.02.024
[4] 于玲. 鼻腔冲洗联合药物治疗婴幼儿变应性鼻炎的疗效分析[J]. 中国妇幼保健, 2017, 32(16):3986-3987. doi:10.7620/zgfybj.j.issn.1001-4411.2017.16.100.
[5] 杨笑染, 刘为民, 张淼, 等. 宁夏回族变应性鼻炎患者鼻腔冲洗治疗的临床观察[J]. 宁夏医学杂志, 2015, 37(2):148-150. doi:10.13621/j.1001-5949.2015.02.0148. YANG Xiaoran, LIU Weimin, ZHANGNIAO, et al. Clinical observation on nasal irrigation treatment in patients with allergic rhinitis[J]. Ningxia Medical Journal, 2015, 37(2):148-150. doi:10.13621/j.1001-5949.2015.02.0148.
[6] 林旸. 不同方法治疗变应性鼻炎的疗效观察[J]. 中国现代医药杂志, 2016,18(12):20-22. doi:10.3969/j.issn.1672-9463.2016.12.006. LIN Yang. Curative effect of allergic rhinitis treated by varied intervention[J]. Modern Medicine Journal of China, 2016, 18(12):20-22. doi:10.3969/j.issn.1672-9463.2016.12.006.
[7] Lierl MB. New developments in the treatment of pediatric allergic rhinitis and conjunctivitis[J]. Pediatr Ann, 2014, 43(8):e192-e200. doi:10.3928/00904481-20140723-09.
[8] Licari A, Ciprandi G, Marseglia A, et al. Current recommendations and emerging options for the treatment of allergic rhinitis[J]. Expert Rev Clin Immunol, 2014, 10(10):1337-1347. doi:10.1586/1744666X.2014.955476.
[9] Bernstein DI, Schwartz G, Bernstein JA. Allergic rhinitis: mechanisms and treatment[J]. Immunol Allergy Clin North Am, 2016, 36(2):261-278. doi:10.1016/j.iac.2015.12.004.
[10] 刘岷, 李彩霞, 张秋红. 罗红霉素联合丙酸氟替卡松鼻喷雾剂治疗变应性鼻炎的研究[J]. 中国民族民间医药, 2011, 20(15):10,12. doi:10.3969/j.issn.1007-8517.2011.15.008.
[11] 陈祖尧, 罗志葵, 朱发梅, 等. 糖皮质激素对变应性鼻炎豚鼠鼻黏膜嗜酸性粒细胞及肥大细胞浸润及P物质含量的影响[J]. 中南医学科学杂志, 2017, 45(2): 122-126. doi:10.15972/j.cnki.43-1509/r.2017.02.004. CHEN Zuyao, LUO Zhikui, ZHU Famei, et al. Effect of glucocorticoid on the infiltration of eosinophils, mast cells andSP in nasal mucosa of guinea pigs with allergic rhinitis[J]. Medical Science Journal of Central South China, 2017, 45(2):122-126. doi:10.15972/j.cnki.43-1509/r.2017.02.004.
[12] 吴杏梅, 许庚. 鼻用糖皮质激素联合鼻用抗组胺药在变应性鼻炎中的应用[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(2):170-172. doi:10.3760/cma.j.issn.1673-0860.2014.02.019.
[13] 徐才成, 曾玉芝, 章学军. 不同浓度盐水鼻腔冲洗治疗变应性鼻炎效果观察[J]. 白求恩医学杂志, 2017, 15(2):178-180. doi:10.16485/j.issn.2095-7858.2017.02.018.
[14] 史丽, 赵莉, 张红萍. 变应性鼻炎的长期抗炎治疗[J]. 山东大学耳鼻喉眼学报, 2017, 31(3):9-12. doi:10.6040/j.issn.1673-3770.0.2017.184. SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(3):9-12. doi:10.6040/j.issn.1673-3770.0.2017.184.
[15] 关凯, 李丽莎. 鼻腔冲洗在变应性鼻炎防治中的应用[J]. 山东大学耳鼻喉眼学报, 2017, 31(3):22-27. doi:10.6040/j.issn.1673-3770.0.2017.151. GUAN Kai, LI Lisha. Nasal irrigation and its role in the treatment of allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(3):22-27. doi:10.6040/j.issn.1673-3770.0.2017.151.
[1] QIN Ya′nan, WANG Lin, JIANG Yan, YAN Shu, CHEN Min, YU Longgang, LI Na. Characteristics of the distribution of inhaled allergens in patients with allergic rhinitis in Qingdao from 2008 to 2017 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 67-72.
[2] ZHANG Wei, LIU Yonggang, JIANG Lingyan. Clinical effect of budesonide nasal irrigation shortly after functional endoscopic endonasal surgery of chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 128-130.
[3] HONG Dongdong, LIU Yuanxian, ZOU Lianqiang, WENG Juanling, DENG Wenxian. An analysis of 764 positive skin prick test results for Dermatophagoides farinae in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 119-123.
[4] QI Yan, LIU Junqi, PENG Shuya, LUO Kai, ZHANG Mingxia, WANG Zhenlin. Therapeutic ecacy of endoscopic elective vidian neurectomy for moderate-severe persistent allergic rhinitis with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 109-113.
[5] Yinshi GUO,Hui LU. Research progress of group Ⅱ innate lymphoid cells in the allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 9-12.
[6] CAO Cheng, XU Yu. Clinical compliance and related factors to sublingual immunotherapy in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 114-118.
[7] Qianhui QIU,Junxiao GAO. Synchronous control and long-term efficacy of specific immunotherapy for allergic rhinitis and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 33-37.
[8] JIN Xing, HU Dayu, ZHU Li, DENG Furong, LIU Junxiu. Correlation between PM2.5 and upper airway resistance in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 77-80.
[9] LI Lisha, GUAN Kai, WANG Zixi, CUI Le. The effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 81-87.
[10] HONG Haiyu, XU Guangfu, YANG Shuowei, SU Rongfei, HUANG Yili, CHI Mengshi,WANG Weihao,YANG Qintai. The prevalence and risk factors of bronchial asthma in patients with allergic rhinitis in Guangdong Province [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 94-98.
[11] WANG Yakun, ZHANG Yu, SONG Xicheng. Analysis of pulmonary function and its influencing factors in chronic rhinosinusitis without lower airway disease [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 99-102.
[12] WANG Jianwei, ZHANG Yu, SONG Xicheng. Analysis of pulmonary function of patients who developed chronic rhinosinusitis with nasal polyps and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 103-108.
[13] LU Hangui, LIN Xinsheng, YAO Danmian, WEI Yongxin, LI Chuangwei. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 66-70.
[14] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[15] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] WANG Xiao-feng,LIN Chang,CHENG Jin-mei . Expression of ABAD in inner ears and its clinical significance in different age mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 207 -211 .
[3] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[5] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[6] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 227 -227 .
[7] LIN Feng,LIANG Yong,LU Yong-tian,WAN Li-xia . Classification and surgical treatment for nasal inverted papilloma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 231 -233 .
[8] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[9] WANG Xu,ZHANG Hua,LV Li-ping,CUI Lei,LI Miao . Quality of tear film of adolescence during internet terminal use[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 265 -268 .
[10] YU Zhi-liang,WANG Wei-wei,WANG Ming-hua . Excision of huge epiglottis cysts under MedtrnicXPS3000 in 23 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 278 -279 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd