自噬在变应性鼻炎发病的作用机制研究

doi:10.6040/j.issn.1673-3770.0.2022.428

Abstract

Abstract: Autophagy is an evolutionarily highly conserved catabolic process that plays a key role in cell growth and development, innate and adaptive immunity, and programmed cell death. In recent years, autophagy has become a focus of research in the field of immunity and oncology, and there is increasing evidence that altered expression of autophagy-related genes may be involved in the pathogenesis of allergic inflammation through the regulation of inflammatory factors, and that autophagy can be targeted for treatment. New studies have shown that autophagy is involved in the pathogenesis of allergic rhinitis(AR)by regulating the activation and function of T cells and affecting respiratory epithelial fibrosis. There is no effective targeted treatment for the global allergic disease of AR. In this review, we address the role of autophagy in the pathogenesis and treatment of allergic inflammation and in the pathogenesis of AR, with the aim of providing new strategies for autophagy as a therapeutic target for AR.

Key words: Autophagy, Allergic rhinitis, Allergic inflammation, T-cell, Fibrosis of epithelium

CLC Number:

R765.22

ZHU Han, LIU Xuexia, ZHANG Hua. Study on the role of autophagy in the pathogenesis of allergic rhinitis[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(1): 79-86.

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