氧化应激在老年性聋发病机制中的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.518

Abstract

Abstract: Presbycusis is a sensorineural hearing loss caused by senescence of the inner ear and auditory cortex. Oxidative stress plays a key role in the occurrence and development of presbycusis. During aging, mitochondrial damage and the release of reactive oxygen species(ROS)promote each other, leading to oxidative stress and a variety of subsequent pathophysiological processes such as an imbalance in mitochondrial quality control, ubiquitin-proteasome system disorders, and programmed cell death. Antioxidants play a role in scavenging ROS, regulating mitochondrial function and inhibiting programmed cell death, and have shown great potential in the prevention and treatment of presbycusis. This review focuses on the progress of research of oxidative stress and subsequent cellular processes in the pathogenesis of presbycusis and antioxidants in delaying presbycusis in order to provide a theoretical basis for its treatment.

Key words: Presbycusis, Oxidative stress, Mitochondrial quality control, Programmed cell death

CLC Number:

R764.35

ZHOU Yingdong, ZHANG Mengxian, WANG Qingling, KANG Haoran, GUO Xiangdong. Progress of research of oxidative stress in the pathogenesis of presbycusis[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(1): 72-78.

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Progress of research of oxidative stress in the pathogenesis of presbycusis

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