Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (1): 95-98.doi: 10.6040/j.issn.1673-3770.0.2024.375

• Original Article • Previous Articles    

Primary high-grade non-intestinal-type adenocarcinoma of the nasal cavity: a case report and review of the literature

PENG Zhonghua, CHEN Zhu, YUAN Luohua, YU Shaolan, MA Yuling   

  1. Department of Otorhinolaryngology, Sichuan Provincial Maternal and Child Health Care Hospital, Sichuan 610031, Chengdu, China
  • Published:2026-02-13

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Abstract: Objective To explore the clinicopathological characteristics, diagnosis, and therapies of non-intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Methods Retrospectively analyzed the clinical presentation, imaging manifestations, pathological findings, and follow-up data of a pediatric case of high-grade NITA. Summarize the diagnosis and treatment strategies, as well as the prognosis of NITA of the nasal cavity and paranasal sinuses, based on literature reviews. Results The patient underwent tumor resection of the left nasal cavity + sinus opening surgery by nasal endoscopy. Postoperative pathology confirmed a malignant nasal cavity tumor, immunohistochemistry showing positivity for CK7 and negativity for CK20, CDX2 and SOX10. No recurrence was observed during follow-up. Conclusion High-grade NITA of the nasal cavity and paranasal sinuses is rare, and pathological biopsy remains the gold standard for diagnosis. Complete surgical resection with negative margins is the primary treatment, and the state of the margins is a critical prognostic factor.

Key words: Nasal cavity neoplasms, High-grade non-intestinal-type adenocarcinoma, Adenocarcinoma, Pathological characteristics, Prognosis

CLC Number: 

  • R739.62
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