Table of Content

16 February 2009 Volume 23 Issue 1

  

Articles

Risk factors of snoring among college students

LI Ye, LU Meiping, TANG Shaowen, SHEN Chong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  1-3 . 

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To investigate the population distribution and risk factors of snoring among college students, and to provide a theoretic basis for preventing and controlling snoring. MethodsCluster sampling was applied to 485 students, in the same grade, who were investigated through questionnaires and physical examinations. ChiSquare test and Logistic regression analysis were used to evaluate the risk factors of snoring. ResultsFour hundred and eightyfive questionnaires were received with a prevalence of 35.6%. Gender, obesity, diseases of the pharynx and drinking showed significant correlations with snoring. Multivariate logistic regression analysis further indicated that being male, overweight and diseases of the pharynx had a statistical relation to snoring. ConclusionThe prevalence of snoring among college students is high. Obesity, drinking and diseases of the pharynx are risk factors of snoring.


Seasonal effect on children with obstructive sleep apnea hypopnea syndrome

LIN Di，TIAN Li

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  4-5 . 

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To explore the effect of the season on children with obstructive sleep apnea hypopnea syndrome by polysomnogram. Methods21 children with OSAHS were monitored with PSG in summer and in winter from Dec 2006 to Sep 2008 in our hospital. The observed variables included AHI, ASaO2, LSaO2, ＞3%ODI, supine apnea and hypopnea index, snoring index and N/A of the adenoid. ResultsThere were no significant differences of N/A of the adenoid and ASaO2 between the paired variables with a P value of 0.261?2 and 0.062?2. AHI, LSaO2, ＞3%ODI, supine respiration event index and snoring index were significantly different with a P value of 0.000?0, 0.003?1, 0.002?8, 0.010?2 and 0.004?6, respectively. ConclusionClinical degrees of OSAHS are different in children by seasons, which is different from adults.


ARelationship between expression of Survivin and radiosensitization effect of EGCG in xenotransplanted nasopharyngeal carcinoma

LEIXun, LIU Qianghe, KONG Zhongyu, XIANG Qiu, GENG WANping, HUANG Hui, DONG Yiyuan, LIU Fangxian

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  6-9 . 

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To investigate the relationship between expression of Survivin and radiosensitization effects of EGCG in the in vivo growth of nasopharyngeal carcinoma. MethodsThe nasopharyngeal carcinoma undifferentiated cell line (CNE2) was subcutaneously inoculated into 20 nude mice (46weeks, female), and the volume and the shorter diameter of tumors were determined. When the shorter diameter of tumors reached 46?mm, NS, EGCG(50?mg/kg·w), radiotherapy(15?Gy), and EGCG(50?mg/kg·w) followed by radiotherapy(15?Gy) 24 hours later, were administered to the animals. The volume and the shorter diameter of tumors were checked. The excised tumor masses on the 21st day after administration were frozen and processed for reverse transcriptionpolymerase chain reaction(RTPCR) to investigate expression of Survivin mRNR. At the same time, one part of each tumor mass was processed for immunohistochemical TUNEL staining to get the apoptosis index(AI). ResultsEGCG in combination with radiotherapy showed a significant inhibitory effect on both tumor growth and expression of Survivin mRNA（P＜0.05). The apoptosis index increased after EGCG treatment in combination with radiotherapy（P＜0.05）. ConclusionEGCG is a good choice for the treatment of nasopharyngeal carcinoma and has radiosensitization on nasopharyngeal carcinoma. Survivin is a molecular agent taking part in the course of apoptosis induced by EGCG in combination with radiotherapy.

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Expression of Slit2 and its correlation with microvessel density in hypopharyngeal squamous cell carcinoma

YAO Lei1, ZHANG Zhonghua1, MA Chao2, LEI Dapeng1,　PAN Xinliang1


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  10-14 . 

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To investigate expression of Slit2 and its correlation with microvessel density in human hypopharyngeal squamous cell carcinomas, and to analyze their influences on the biological behavior of human hypopharyngeal squamous cell carcinoma. MethodsExpressions of Slit2 and CD34labeled microvessel density (MVD) were measured by immunohistochemical staining (Envision), and expression of Slit2 mRNA in 24 cases of fresh tissues was determined by reversetranscript polymerase chain reaction. ResultsThe positive rates of Slit2 in cancerous tissues and paracancerous tissues were respectively 65.2% and 40.5%（χ2=6.329，P<0.05）. Slit2 mRNA expressions between them also had statistical significance (t=8.230, P<0.05). Expression rate of Slit2 and enumeration of MVD were significantly associated with tumor size，TNM stage, and lymph node metastasis. Enumeration of MVD was increased in Slit2positive tissues（t=2.273, P<0.05）. Expression of Slit2 had a positive correlation with MVD（rs=0.430，P<0.05）. ConclusionExpression of Slit2 and enumeration of MVD are significantly higher in hypopharyngeal squamous cell carcinoma than in normal mucosa. They have significant relations to tumor invasion and lymph node metastasis，and the mechanism might be that Slit2 mediated new vessel formation in tumors.


Articles

Effects of testosterone on proliferation and telomerase activity of Hep2 cells

WANG Hongbo¹,　TIAN Jun²,　LI Hongmei³


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  15-17 . 

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To investigate the effects of testosterone on proliferation and telomerase activity of Hep2 cells. MethodsProliferation activity of Hep2 cells was assessed by MTT assay. Expressions of Androgen Receptor antigen and Telomerase antigen were determined at 48?h after testosterone (10-8mol/L ) treatment by an immunocytochemistry method. ResultsOD values of Hep2cells before treatment and at 48?h after testosterone (10-8mol/L) treatment were 0.150±0.008 and 0.281±0.010. Testosterone at a concentration of 10-8mol/L may stimulate proliferation activity of Hep2 cells. Others had no such effect. Testosterone antigen activity was respectively 95.73% and 93.84% before and after testosterone (10-8mol/L) treatment, with no significant changes. However, telomerase activity increased from 52.35% to 89.21%, with obvious statistical significance. Slides with strong expression of telomerase increased from 2 to 8. ConclusionThe Hep2 cell line is androgensensitive cell. Testosterone can stimulate proliferation of Hep2 cells through increasing telomerase activity. Therefore, it has potential to develop endocrine therapy and antitelomerase drugs for laryngeal carcinoma.


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Transnasal endoscopic surgery for anterior skull base and sella region tumors

CHEN Chengfang¹, LI Xuezhong¹, XU Haojie², CAI Xiaolan¹,
ZHANG Liqiang¹, LI Yanzhong¹, LIU Zhonglu¹


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  18-22 . 

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To explore the effect of a transnasal endoscopic approach for anterior skull base and sella region tumors. MethodsClinical data of 16 patients with anterior skull base tumors from November 2004 to June 2008 were retrospectively analyzed. All of them received transnasal endoscopic surgeries and one of them underwent evisceration of the orbit. All the operations were performed under general anesthesia. There were 6 pituitary adenomas, 5 inverted papilloma，1 squamous cell carcinoma， 1 chordoma, 1 primitive neuroectodemal tumor, 1 olfactory neuroblastoma, and 1 ossifying fibroma. The followup period ranged from 3 months to 4 years. ResultsTumors were totally removed in 15 cases and subtotally removed in 1 case. Cerebrospinal leakage appeared after the operations and was cured by two operations in 1 case. There was no intracranial hemorrhage, intracranial infection or death in any patient. ConclusionAn endonasal endoscopic approach can expose and completely remove anterior skull base and sella region tumors in appropriate cases and can identify the deep tissues. Reconstruction of the skull base and dural treatment is not necessary in most cases. Operators must have adequate anatomic knowledge, surgical technique and experiences as well as advanced surgical apparatuses.


Human papilloma virus expressions in nose and larynx diseases

ZHUANG Xuewei, XIA Xiyan,　LU Hongxia,　et al

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  23-25 . 

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To evaluate the relationship between human papilloma virus(HPV) infection and diseases in the nose and the larynx, such as squamous epithelial and adenoepithelial carcinoma, papilloma, polyp, and inflammation. MethodsExpressions of HPV6, 11, 16, 18, 31, 33,42,51,52,56 and 58 were determined using SP staining of immunohistochemistry. ResultsExpression percentage of HPV was 41.38% in squamous carcinoma, 20.00% in adenocarcinoma, 47.62% in squamous papilloma, 20.00% in glandular papilloma, 7.14% in squamous polyp,3.57% in adenopolyp, and not found in allergic rhinith and nasosinusitis. Correlation analysis showed that there was no significant difference (P＞0.05) in HPV infection rate between squamous carcinoma and adenocarcinoma, between squamous papilloma and adenopapilloma, or between squamous polyp and adenopolyp, but there was a significant difference (P＜0.05) in HPV infection rate between squamous carcinoma plus squamous papilloma and adenocarcinoma plus adenopapilloma, and also there was a significant difference (P＜0.05) in HPV infection rate between squamous carcinoma plus papilloma and polyp, and between adenocarcinoma plus papilloma and polyp. ConclusionHPV infection may have a correlation with the genesis and development of tumors in the nose and the larynx. The probability of HPV infecting the squamous epithelium is higher than that of HPV infecting the adenoepithelium.


Molecular genetic analysis of the mtDNA A1555G mutation in patients with nonsyndromic hearing loss

LIU Tao¹, BAO Yin², YAN Jiangwei³, LI Lingxiang¹, LI Jianrui⁴

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  40-42 . 

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To analyze the prevalence of an AtoG mutation at nucleotide 1555 of the mitochondrial genome in 102 patients with nonsyndromic hearing loss in Erdos, Inner Mongolia. MethodsData on the medical history of 102 deaf school students were collected by a questionnaire survey. An audiological examination was conducted with puretone audiometry (Madsen Orbiter 922) and acoustic immittance measurement(Madsen ZODIAC 901). The MtDNA 12SrRNA A1555G mutation was identified by restriction enzyme AIW26I digestion. ResultsAll 102 patients were proved to have sensorineural hearing impairment. 54 of them had used aminoglycoside antibiotics. 7 cases (6.9%) carried the mtDNA A1555G mutation. ConclusionThe mtDNA 12S rRNA A1555G mutation has a relatively high incidence in people with nonsyndromic sensorineural hearing loss. The MtDNA A1555G mutation is related to aminoglycoside antibioticsinduced deafness, which can cause genetic susceptibility to aminoglycoside antibiotics ototoxicity.


Balanced fast field echo in diagnosis of trigeminal neuralgia with blood vessel compression at the cerebellopontine angle

GAO Xingqiang¹, LI Ming², ZHANG Qizhou³


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  43-45 . 

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To assess the clinical value of the balanced fast field echo (BFFE) in detection of trigeminal neuralgia with blood vessel compression at the cerebellopontine angle. MethodsConventional magnetic resonance imagings and BFFE imagings in 50 cases were retrospectively analyzed. ResultsAll trigeminal nerves of the 50 cases exhibited a clear signal on BFFE imaging and the signal intensities of the blood vessel of the cerebellopontine angle of 45 cases was relatively similar to the trigeminal nerves, which made a sharp contrast with the high signal intensity of the cerebrospinal fluid of the cerebellopontine angle. In 17 of the 42 cases of blood vessel compression of the cerebellopontine angle, the trigeminal nerves exhibited an obvious aversion. ConclusionThe balanced fast field echo is a fast and high performance technique for diagnosing trigeminal neuralgia with blood vessel compression of the cerebellopontine angle.


Clinical value of the acoustic reflex in patients with myasthenia gravis

BAI Yanxia, WANG Xuan


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  46-47 . 

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ObjectiveTo study the clinical value of the acoustic reflex in patients with myasthenia gravis. Methods16 patients who were diagnosed as myasthenia gravis with initial head and neck symptoms were determined by a pure tone audiometer and acoustic immitance measurement and then the acoustic reflex was reexamined 30 min after injection of Neostigminum sulfate 0.5～1?mg. Results13 patients (81.3%) had positive results. ConclusionThe acoustic reflex has advantages such as sensitive, convenient and so on, and is an objective, reliable and atraumatic examination in diagnosis and surveillance of myasthenia gravis.


Pathogenic bacterium and its resistance in aural inflammatory diseases

ZHANG Xiuxiu， ZHANG Qiugui， ZHU Fugao， ZHANG Xiaoheng


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  48-51 . 

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To explore the bacteriology of chronic suppurative otitis media and diffuse external otitis and examine antibiotic sensitivity of a certain isolated bacterium for guiding appropriate use of antibiotics. MethodsMiddle ear or deep external acoustic meatus purulence were collected from 238 patients with chronic suppurative otitis media or diffuse external otitis and cultured for bacteria, fungi and an antimicrobial susceptibility test. ResultsThere were 206 strains of microbes isolated from the 238 cases. Staphylococcus aureus accounted for 34.95％, methicillinresistant coagulase negative staphylococcus for 20.38％， pseudomonas aeruginosa for 7.28％， and fungi for 18.45％. The antibiotic sensitivity was variable among the isolated bacterial strains. ConclusionStaphylococcus aureus is the main pathogenic bacteria of chronic suppurative otitis media and diffuse external otitis, and methicillinresistant coagulase negative staphylococcus is the second. The infective rate of fungi increased. Pathogenic bacteria have resistance to commonly used antibiotics. We should perform bacterial culture, fungal culture, and antimicrobial susceptibility tests for patients with chronic suppurative otitis media and diffuse external otitis in order to choose appropriate antibiotics.


Epidemiology of allergic rhinitis in bronchial asthma patients and correlation between allergic rhinitis and bronchial asthma

XUE Fei¹， LI Zeqing¹，　JIANG Manjie¹， CHENG You¹，　WANG Qiuping¹，　XIN Xiaofeng²


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  54-56 . 

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To study the epidemiology of allergic rhinitis in bronchial asthma patients from Nanjing, China, and to analyze the correlation of clinical characteristics between allergic rhinitis and bronchial asthma. MethodsA questionnaire survey of 134 bronchial asthma patients from the city of Nanjing was carried out. Their clinical situations and treatment status were investigated in detail, and a database was set up for statistics. ResultsIn 134 bronchial asthma patients, 82 (61.2%) were accompanied with allergic rhinitis. The episode ages and their courses of diseases of both groups had no significant differences (P＞0.10). In respect of severity of bronchial asthma in 82 patients, 56 were in the first degree, 21 in the second degree, 4 in the third degree, and 1 in the fourth degree. In respect to classification of allergic rhinitis, 65 were intermittent and 17 persistent. In respect to severity of allergic rhinitis, 63 were mild and 19 moderatesevere. Of all the asthma patients, 42 (31.3%) had a family history of airway inflammatoryrelated diseases in the direct parent tertstrain. ConclusionThe morbidity of allergic rhinitis in bronchial asthma patients is high in Nanjing, China. There are correlations between clinical characteristics of allergic rhinitis and bronchial asthma, and their classification and severity are highly coherent.


Effects of upper airway allergic inflammation on the lower airway

XU Dingyuan¹, LI Zeqin¹,　WU Bo², ZHANG Yong¹,　JI Junfeng¹, XUE Fei¹,　WANG Qiuping¹


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  57-59 . 

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To observe pathological and immunological changes of the lower airway in intranasal ovabumin induced animal models of allergic rhinitis in guinea pigs. Methods12 Hartley guinea pigs (250300?g) were randomly divided into two groups (the control group and the allergen exposure group). Guinea pigs were intranasally sensitized with ovalbumin absorbed on aluminum hydroxide twice a day for 10 days, and after one week they were challenged with 2% ovalbumin solution once every day for a total of 7 times. The negative control group was shamsensitized and shamchallenged by PBS. The symptoms of allergic rhinitis as well as asthma were evaluated. Eosinophils infiltration and pathological changes of the nasal and lung tissues were observed. Levels of IgE and IL5 of the serum were determined by the Elisa method. ResultsIn the allergen exposure group, symptoms of sneezing, nasal scratching, nasal and rhinorrhea were induced after ovalbumin challenge. IgE and IL5 levels increased after challenges. Eosinophil infiltration in the mucosa of the nose and the lungs was more obvious in the allergen exposure group in comparison with the negative control group (P<0.001). Pathological changes were also founded in the nose and lung tissues of the allergen exposure group. ConclusionIt is clear that antigenic stimulation of the upper part of the respiratory mucosa has ripple effects on the lower airway and leads to changes in immunology, which supports the united airway concept.


Grillform suture of bone and cartilage of the nasal septum in the treatment of deflection of the nasal septum in teenagers

MA Jing, HE Junling, ZHOU Liuqing


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  60-61 . 

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To explore the feasibility and curative effect of grillform suture of bone of the nasal septum and cartilage in the treatment of deflection of the nasal septum in teenagers. MethodsThe bulk which initiated from bone of the nasal septum and cartilage from inframucosa to the nasal roof and basis nasi，was removed under general anesthesia. The cristae in the lateral protrusion of the pars cartilaginea septi nasi was repaired to evenness, the cartilage was dissected to a stickform of 0.30.5?cm width. Based on the size of the flankcurvature radian in the cartilaginous and the bony parts, bone fracture was used to flatten or trim the bony part, the buck of closing cartilage was from upper inframedium to 1/4 lower infra medium and interruptedly sutured with a 5° needle of absorption line by 0.1cm. Grill of the bone and cartilage were reestablished and the incision was sutured. ResultsComplications were not found in all patients during a 23.5 year followup. The nasal passage was good for ventilation, the external nose shape was not changed, and the nasal septum had no perforation and flutter in forced breathing. ConclusionGrillform suture in bone of the nasal septum and cartilage is a feasible method for recurring deflection of the nasal septum in children.


Tracheotomy and sutured tracheostomy in the treatment of complicated bronchial foreign bodies

L Zhenghua, XU Wei, ZHANG Jun, CAO Hongyuan


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  68-69 . 

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To explore a feasible operative method for removal of complicated foreign bodies through a tracheoscope by tracheotomy and sutured tracheostomy. MethodsFive patients, aged from 4 to 8 years with complicated airway foreign bodies were subjected to removal operations from March 2004 to July 2007. Foreign bodies included one plastic ballpen cap, two smooth plastic beads, one steel ball and one smooth ceramic stick. Under general anesthesia， foreign bodies were loosened and pulled to the subglottic region. Simultaneously， tracheotomy was performed and the foreign body was extracted by cervical tracheotomy. The trachea was sutured till respiration was safe and steady. Permanent tracheotomy was not necessary. ResultsAll succeeded without complications, such as dyspnea, pneumoderma, and infection. Tracheal stenosis was not found after a 12month or more period. ConclusionIt is feasible to extract complicated airway foreign bodies through a tracheotomy with bronchoscopic control and to suture the trachea instantly after removal of the foreign bodies. The key point of success is to avoid profuse attempts of extraction through the glottis and keep smooth breathing.


Application of laryngeal endoscope in diagnosis and treatment of foreign bodies in the hypopharynx

HE Zhongyang， PANG Shuxing， SU Hechao


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  70-71 . 

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To evaluate a 90 degree laryngeal endoscope used in diagnosis and treatment of foreign bodies in the hypopharynx. Methods102 patients with foreign bodies lodged in the hypopharynx but which had failed to be identified with indirect laryngoscopy were reexamined under video with a 8?mm,90 degree laryngeal endoscope from Mar.2003 to Sep.2007. Results98 cases with foreign bodies in hypopharynx were found and removed successfully under laryngeal endoscope. 4 cases which had failed to be identified foreign bodies in hypopharynx were referred for xray examination, foreign bodies were embedded in the entrance of the esophagus. ConclusionForeign body lodged in the hypopharynx can be easily located and removed under 90 degree laryngeal endoscope, which has the advantages of good illumination, clear visualization, and convenient manipulation.The technique has been proven to be efficient, safe, well tolerated and to reduce missed diagnosis.


One patient with tracheal bronchus malformation combined with a foreign body: Literature review

MA Lianshan, ZHANG Xiaoyan, XU Wenguang, TAO Yanli, LIU Liting


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  72-73 . 

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To improve diagnostic technique on tracheal bronchus diseases. MethodsThe clinical data of 1 patient with a tracheal bronchus foreign body were retrospectively analyzed. ResultsBy screw CT gas channel and threedimensional reconstruction, the tracheal bronchus was found accompanied by a bronchus foreign body. The foreign body was taken out, and the tracheal bronchus was not processed. ConclusionThe tracheal bronchus stems from the trachea wall′s bronchial tube dystopia above the carina of the trachea or unnecessary malformation. The screw CT lung gas channel and threedimensional reconstruction may help diagnosis. It must not be used if there is not a clinical symptom.


Clinical observation on suspensory intraocular lens implantation in the ciliary groove after ocular trauma

LI Jun, YUAN Gongqiang, DONG Xiaoguang


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  76-78 . 

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To evaluate the effect of suspensory intraocular lens implantation in the ciliary groove after ocular trauma. MethodsThe clinical data were retrospectively analyzed in 19 eyes of 19 patients treated with suspensory intraocular lens implantation in the ciliary groove. ResultsDuring a followup of 6 to 25 months, postoperative correct visual acuity of 0.3 to 0.5 was achieved in 4 eyes (21.1%), 0.6 to 0.7 in 5 eyes (26.3%), and 0.8 to 1.0 in 9 eyes (52.6%) without severe complications. ConclusionSuspensory intraocular lens implantation in the ciliary groove is an effective and safe surgery for the aphakic eye after ocular trauma.


Effects of phacoemulsification on intraocular pressure and anterior chamber depth

LIU Xinquan, LI Mingfei, ZHU Huaying


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  79-82 . 

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To investigate the effects of phacoemulsification and intraocular lens implantation on intraocular pressure (IOP) and anterior chamber depth in patients with cataract or cataract combined with angle closure glaucoma. Methods361 patients (481 eyes) with senile cataract (cataract group) and 44 patients (52 eyes) with cataract combined with angle closure glaucoma (cataract with glaucoma group) accepted phacoemulsification and intraocular lens implantation from July 2005 to May 2007, and were followed up for 325 months. ResultsThere was a significant difference between preoperative and postoperative IOP (t=9.270,P＜0.01)　in the cataract group, and the preoperative IOP was 14.86±3.79?mmHg and the postoperative IOP was 12.56±3.43?mmHg; there was a significant difference between preoperative and postoperative IOP （t=3.29,P＜0.01） in the cataract with glaucoma group, and the preoperative IOP was 19.92±3.76?mmHg and the postoperative IOP was 16.52±3.15?mmHg; there was no significant difference in preoperative IOP （t=-2.437，P＞0.05）and the IOP 3 months after operation （t＝2.154，P＞0.05）between the two groups. There was a significant difference between the preoperative and postoperative depths of the anterior chamber（t=7.781，P＜0.01） in the cataract group, and the preoperative depth of the anterior chamber was 2.28±0.32?mm and the postoperative depth of the anterior chamber was 3.04±0.39?mm; there was a significant difference between preoperative and postoperative depths of the anterior chamber（t=4.528，P＜0.01）in the cataract with glaucoma group and the preoperative depth of the anterior chamber was 1.69±0.35?mm and the postoperative depth of the anterior chamber was 2.82±0.41?mm; there was a significant difference between the two groups in the preoperative depth of the anterior chamber （t=8.325,P＜0.01）and no significant difference after operation（t=2.86,P＞0.05）. ConclusionPhacoemulsification and intraocular lens implantation are effective in curing cataract and decreasing IOP. If the IOP of patients with cataracts and glaucoma was controlled to normal preoperatively, the antiglaucoma medication was no longer needed after phacoemulsification and intraocular lens implantation.


Silicone oil removal to control high intraocular eye pressure

TAN Ruili， WANG Yu， JI Qiang, FAN Chuanfeng


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  83-84 . 

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To evaluate the effect of silicone oil removal on control of high intraocular pressure (IOP) of eyes after silicone oil injection. Methods84 cases subjected to inhospital treatments from June 2006 to March 2007 were grouped based on whether there was lens and silicon oil emulsification. Preoperative and postoperative IOP and other conditions were compared. ResultsAfter silicone oil was removed, the intraocular pressure was controlled to normal in 48 cases (57.1%). There were no statistical differences in efficiency between phakic and aphakic eyes (P>0.05). There were significant statistical differences in efficiency between the emulsified silicone oil cases and the nonemulsified cases (P<0.05). ConclusionSilicone oil removal is effective in controlling high IOP after intravitreal silicone oil injection. Cases without silicone oil emulsification may have better therapeutic value than those with emulsification oil.


Trichiasis electrolyzer in treatment of congenital lacrimal fistula

CHEN Jianhua, CHEN Wei


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  85-86 . 

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To explore the therapeutic effect of the Trichiasis electrolyzer on congenital lacrimal fistula. MethodsFirst an exploring needle or irrigating needle was used to determine the course and total length of the fistula in13 cases of congenital lacrimal fistula patients. Second, bathing the lacrimal passage was carried out to make sure that the fistula and the lacrimal sac were connected. An electrolysis needle was inserted into the whole fistula and the source of electricity was turned on for 15 to 20 seconds until an air bladder appeared in the orifice of the fistula. Antibiotics were postoperatively used. ResultsAll cases were cured without epiphora. None recurred during a 16 month followup after the treatment. ConclusionThe Trichiasis electrolyzer is convenient, safe, effective without bleeding, infection, and scaring for congenital lacrimal fistula.


Optical coherence tomography combined with fundus photochromy in locating central serous chorioretinopathy

WANG Guanghui, YOU Xinying, ZHANG Dan, L Fuli


JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2009, 23(1):  87-89 . 

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To explore the clinical significance of locating central serous chorioretinopathy( CSC) by optical coherence tomography(OCT) combined with fundus photochromy. Methods43 patients(49 eyes with 59 leakage spots) proved by fluorescein fundus angiography(FFA) were subjected to OCT combined with fundus photochromy. The distance from spotlike leakage to the fovea was measured by FFA and OCT combined with fundus photochromy. ResultsAmong the 59 leakage spots, 54(91.53%) had positive signs in OCT or fundus photochromy . The average distance from the leakage to the macula fovea by the two methods was 2.15±1.06?mm and 2.09±1.04?mm(P＞0.05). ConclusionOCT combined with fundus photochromy can be used to locate CSC.