山东大学耳鼻喉眼学报 ›› 2026, Vol. 40 ›› Issue (4): 119-128.doi: 10.6040/j.issn.1673-3770.0.2025.389

• 论著 • 上一篇    

新型滚轮式睑板腺按摩镊对睑板腺功能障碍患者眼表症状与腺体功能的影响:一项随机对照试验

陈艾,刘春麟,熊晓菁   

  1. 重庆医科大学附属第二医院 眼科, 重庆 400010
  • 发布日期:2026-07-10
  • 通讯作者: 刘春麟. E-mail:570037067@qq.com
  • 基金资助:
    重庆医科大学附属第二医院2023年度护理骨干科研资助计划项目(HL2023-04)

Efficacy of a novel roller-type meibomian gland massage forceps on ocular surface symptoms and gland function in patients with meibomian gland dysfunction: arandomized controlled trial

CHEN Ai, LIU Chunlin, XIONG Xiaojing   

  1. Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  • Published:2026-07-10

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摘要： 目的 探讨新型滚轮式睑板腺按摩镊与传统工具(圆头镊、棉签)在改善睑板腺功能障碍(meibomain gland dysfunction,MGD)患者眼表状况和睑板腺功能方面的效果。 方法 选取确诊为 MGD 的患者共84例(168眼)作为研究对象,按照随机数字表法分为新型睑板腺按摩镊组、圆头镊组、传统棉签组,每组28例。分别采用相应工具进行睑板腺按摩,每周1次,共干预4周。并在干预前及干预后1、2、4周评估研究对象的眼表疾病指数(ocular surface disease index, OSDI)评分、角膜荧光素染色(fluorescein staining, FL)评分、睑板腺排出能力评分及睑板腺分泌物性状评分,从而评估三种睑板腺按摩工具对 MGD 患者的护理治疗效果。 结果 三组患者干预前的一般资料及各观察指标(OSDI、FL、睑板腺排出能力及分泌物性状)基线水平一致,具有可比性(P均>0.05)。干预后第2周起,三组患者OSDI、FL、睑板腺排出能力及分泌物性状评分均较治疗前明显改善,且改善程度随干预时间延长而增加(P均<0.05)。组间比较中,新型滚轮式睑板腺按摩镊在改善患者主观症状(OSDI)、促进睑脂排出及改善分泌物性状方面均优于传统棉签(P均<0.05),且在多个指标上优于或等效于圆头镊;在改善FL评分方面,新型镊与圆头镊效果相当(干预后2周P=0.206,4周P=0.397),但二者均优于棉签组(P均<0.05)。 结论 新型滚轮式睑板腺按摩镊在改善患者主观症状、泪膜稳定性、促进睑脂排出及改善分泌物性状方面均显著优于传统棉签,且在多个指标上优于或等效于圆头镊,为MGD治疗提供了一种更高效、安全的物理干预选择。

关键词: 睑板腺功能障碍, 干眼症, 睑板腺按摩

Abstract: Objective The objective of this study is to compare the efficacy of a novel roller-type meibomian gland massage forceps with traditional instruments(round-tip forceps and cotton-tipped applicator)in managing meibomian gland dysfunction(MGD). The study will evaluate improvements in ocular surface parameters and meibomian gland function. Methods In this randomised controlled trial, 84 patients(168 eyes)diagnosed with MGD were enrolled between April 2023 and April 2024. Participants were randomly allocated to one of three intervention groups: cotton-tipped applicator(n=28), round-tip forceps (n=28), or novel massage forceps(n=28). The study protocol stipulated that all groups receive a standardized meibomian gland massage protocol once per week for a period of four weeks. The primary outcomes encompassed the Ocular Surface Disease Index(OSDI)score, the corneal fluorescein staining(FL)score, the meibomian gland expressibility score, and the meibomian secretion quality score. These were assessed at baseline and at weeks 1, 2, and 4 post-intervention. Results A subsequent analysis of baseline demographic data and all outcome measures(OSDI, FL, meibomian gland expressibility, and secretion quality scores)revealed no statistically significant differences among the three groups, indicating consistent baseline characteristics and comparability(P>0.05). Subsequent to the second week following the intervention, all three groups exhibited significant enhancements in all outcome measures in comparison with baseline, with the extent of the enhancements increasing over time(P<0.05). Inter-group comparisons revealed that the novel roller-type meibomian gland massage forceps was significantly superior to the traditional cotton-tipped applicator in alleviating subjective symptoms(OSDI), promoting meibum expression, and improving secretion quality(P<0.05), and was either superior or equivalent to round-tip forceps across multiple indicators. With regard to the enhancement of FL scores, the novel forceps and round-tip forceps exhibited comparable efficacy(week 2: P=0.206; week 4: P=0.397), yet both were found to be significantly superior to the cotton-tipped applicator group(P<0.05). Conclusion The novel roller-type meibomian gland massage forceps have been demonstrated to be a more efficacious intervention than the traditional cotton-tipped applicator method for alleviating symptoms, restoring tear film stability, and improving meibomian gland function in patients diagnosed with MGD. Its efficacy is comparable to or superior to that of conventional round-tip forceps, suggesting that it is a promising and potentially more efficient tool for clinical practice.

Key words: Meibomian gland dysfunction, Dry eye, Meibomian gland massage

中图分类号: 

  • R777.13
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