中药“益视合剂”辅助治疗儿童弱视

doi:10.6040/j.issn.1673-3770.0.2014.312

摘要/Abstract

摘要： 目的客观评价"益视合剂"的疗效,以指导儿童弱视的临床治疗。方法根据病例选择标准共纳入36例61眼,随机分为对照组及治疗组。对照组(27眼)予以屈光矫正加精细目力训练,治疗组(34眼)在对照组治疗基础上加用"益视合剂",以4周为1个疗程,共3个疗程。于治疗前及每个疗程结束后检查视力,于治疗前和全部疗程结束后行光学相干断层扫描(OCT)检查。观察两组视力情况及黄斑区视网膜神经上皮层厚度。结果 ①治疗后,治疗组总有效率为85.3%,基本治愈率为52.9%;对照组总有效率为59.3%,基本治愈率为29.6%。两组疗效差异有统计学意义(P<0.05),治疗组疗效明显优于对照组,其中屈光不正性弱视及中度弱视疗效较好;②治疗后黄斑区视网膜神经上皮层厚度变薄,尤其是黄斑内环区上方视网膜,外环区上方、鼻侧及下方视网膜厚度变化差异有统计学意义(P<0.05)。结论中药益视合剂作为辅助治疗方法可以显著提高儿童弱视的治愈率,缩短治疗时间,在改善黄斑区形态和功能方面起到一定的作用。

关键词: 弱视, 中药, 益视合剂, 光学相干断层扫描

Abstract: Objective To objectively and scientifically evaluate the efficacy of "Yishi mixture", so as to guide clinical treatment of amblyopia in children. Methods A total of 61 eyes of 36 patients based on inclusion criteria were enrolled in this study. 27 eyes in the control group received routine treatment including vision correction and training from fine work and 34 eyes in the treatment group were treated with "Yishi mixture" based on routine treatment, 4 weeks as a course, and 3 course in total. At the beginning of treatment and at the end of 4, 8 and 12 weeks after the treatment, vision was determined, before the treatment and at the end of 3 therapeutic courses optical coherence tomography (OCT) was used to determine the neurosensory retinal thickness in the macula. Results 1. After 3 courses of therapy, of the treatment group, the effective rate was 85.3% and the main cure rate was 52.9%; of the control group (27 eyes), the effective rate was 59.3% and the main cure rate was 29.6% (P<0.05), especially for ametropic amblyopia and moderate amblyopia. 2. After the treatment, the neurosensory retinal thickness in the macula and the retinal nerve fiber layer thickness had a decrease tendency in different degrees, especially in the inferior inner macula, superior, nasal and inferior outer macula. Conclusion As an adjuvant therapy, the "Yishi mixture" can significantly improve the cure rate of amblyopia in children, shorten the treatment time, and plays some role in improving the form and function of retina and visual cortex.

Key words: Chinese materia medica, Optical coherence tomography, Yishi mixture, Amblyopia

中图分类号:

R777.44

汪新, 魏伟. 中药“益视合剂”辅助治疗儿童弱视[J]. 山东大学耳鼻喉眼学报, 2015, 29(1): 56-59.

WANG Xin, WEI Wei. Chinese materia medica Yishi mixture in treatment of amblyopia in children[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 56-59.

参考文献

[1] 中华眼科学会全国儿童弱视斜视防治学组. 弱视的定义、分类及疗效评价标准[J].中国斜视与小儿眼科杂志,1996,4(3):97-98. National Children's strabismus amblyopic treatment group. The definition, classification and evaluation standard of amblyopia[J]. Chin J strab Pedia Ophthalmol, 1996, 4(3):97-98.
[2] 石荣先,晁小蕊,张建华,等.儿童弱视综合治疗802例临床疗效分析[J].眼科新进展, 2013,33(9):881-882,897. SHI Rongxian, CHAO Xiaorui, ZHANG Jianhua, et al. Analysis of clinical efficacy of comprehensive therapy on 802 cases of children amblyopia[J]. Rec Adv Ophthalmol, 2013, 33(9):881-882, 897.
[3] 林夕梅,郑洁琼. 综合疗法治疗儿童弱视360例临床观察[J].江苏医药,2013,39(20):2475-2476. LIN Ximei, ZHENG Jieqiong. Comprehensive treatment for amblyopia in children: clinical observation of 360 cases[J]. Jiangsu J Med, 2013, 39(20):2475-2476.
[4] 陈澎,王鸿,王静,等.综合疗法治疗儿童弱视166例临床疗效分析[J].山东大学耳鼻喉眼学报,2013,27(3):1-3. CHEN Peng, WANG Hong, WANG Jing, et al. Comprehensive treatment of amblyopia in 166 children[J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(3):1-3.
[5] Nassif N, Cense B, Park B H, et al. In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography[J]. Opt Lett, 2004, 29(5):480- 482.
[6] Huynh S C, Samarawickrama C, Wang X Y, et al. Macular and nerve fiber layer thickness in amblyopia:the Sydney Childhood Eye Study[J]. Ophthalmology, 2009, 116(9):1604-1609.
[7] 刘虹,周欣,章淑华,等.单眼弱视患者黄斑光学相干断层成像检查[J].中国斜视与小儿眼科杂志, 2007, 15(3):119-120. LIU Hong, ZHOU Xin, ZHANG Shuhua, et al. The examination of optical coherence tomography (OCT) in macula of unilateral amblyopia eye [J]. Chin J Strab Pedia Ophthalmol, 2007, 15(3):119-120.
[8] Aguirre F, Mengual E, Hueso J R, et al. Comparison of normal and amblyopic retinas by optical coherence tomography in children[J]. Eur J Ophthalmol, 2010, 20(2):410-418.

相关文章 15

[1]	赵娟,焦万珍,赵博军. UWFSS-OCTA检测糖尿病视网膜病变微循环的变化[J]. 山东大学耳鼻喉眼学报, 2026, 40(2): 80-86.
[2]	朱明琼,李征,刘茹,田涛,彭婧利,吕倩怡,谭华霞. 基于OCT/OCTA的AI筛查系统在抗VEGF治疗糖尿病性黄斑水肿患者效果评价中的应用[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 68-73.
[3]	李世强,马燕,王家伟. 光学相干断层扫描血管成像在全身疾病中的临床应用研究进展[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 127-134.
[4]	王鑫,原晶晶,郝鹏鹏,闫占峰,刘建华,钟利群,刘思溟,吴薇,赵晓阳,张莹. 中药复方治疗突发性聋的疗效和可能机制:一项结合网络药理学研究的回顾性临床分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 6-17.
[5]	黄娇,彭昌福. 甲状腺相关性眼病活动性客观评价的研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 171-178.
[6]	吴丽丽,曲毅. OCTA在病理性近视脉络膜新生血管应用及其在人工智能的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 144-149.
[7]	王新钰,高丽芬,路晖,宋文琦,杨钰. 帕金森疾病的相关视网膜表现[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 156-162.
[8]	刘江川,李鹏伟,郭建强,陆慧琴. 光学相干断层扫描成像在特发性视网膜前膜中的应用研究[J]. 山东大学耳鼻喉眼学报, 2024, 38(1): 138-142.
[9]	买尔哈巴·玉素甫,克里木江·阿不拉,丁琳,秦艳莉,陈雪艺. 伴发于后巩膜葡萄肿的高度近视性白内障眼底病变相关研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 107-114.
[10]	张晓晗,魏丽,杨凯莉,陈海燕,李彦松,王平. 中医辨证论治前后CSC患者OCTA变化及其与视力的相关性研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 115-122.
[11]	赵露,田慧文,孟博,王薇,王艳玲. 颈内动脉闭塞患者黄斑区视网膜脉络膜厚度变化分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 72-76.
[12]	尤冉,郭笑霄,王薇,陈曦,王艳玲. 高度近视患者黄斑区视网膜劈裂分型与脉络膜特征分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 83-87.
[13]	赵泓霄,张晗. 光学放大效应对神经节细胞复合体测量的影响[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 105-109.
[14]	李鹏伟,苏光明,刘江川,穆雅林. 光学相干断层扫描血管成像在2型黄斑毛细血管扩张症中的应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 140-144.
[15]	杨茹,张玉光,徐湘辉,吴雪莲,陶远,谭越. 超声乳化术对老年性白内障黄斑区视网膜结构影响的临床研究[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 97-102.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed