山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (3): 91-94.doi: 10.6040/j.issn.1673-3770.0.2016.392

• 论著 • 上一篇    下一篇

喉鳞癌组织中抑癌基因Maspin和转录因子Ets1的表达及意义

安永明1,穆文利2a,田艳勋3,李伟2b,吴彦桥4   

  1. 1.张家口建国医院耳鼻咽喉科, 河北 张家口 075000;
    2.解放军第251医院 a. 消化内科;
    b. 病理科, 河北 张家口 075000;
    3.邢台市人民医院耳鼻咽喉科, 河北 邢台 054000;
    4.白求恩国际和平医院耳鼻咽喉科, 河北 石家庄 050000
  • 收稿日期:2016-09-07 出版日期:2017-06-16 发布日期:2017-06-16

The significance of Maspin and Ets1 in laryngeal squamous carcinoma.

AN Yongming1, MU Wenli2a, TIAN Yanxun3, LI Wei2b, WU Yanqiao4   

  1. 1. Department of Otolaryngology, Jianguo Hospital of Zhangjiakou, Zhangjiakou 075000, Hebei, China;2a. Department of Gastroenterology, 2b. Department of Pathology, The 251st Hospital of Chinese PLA, Zhangjiakou 075000, Hebei, China;3. Department of Otolaryngology, Peoples Hospital of Xingtai, Xingtai 054000, Hebei, China;4. Department of Otolaryngology, Bethune International Peace Hospital, Shijiazhuang 050000, Hebei, China
  • Received:2016-09-07 Online:2017-06-16 Published:2017-06-16

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摘要： 目的 探讨在喉鳞癌组织中抑癌基因Maspin和转录因子Ets1的表达及意义。 方法 采用免疫组织化学(EnVisionTM)法检测70例手术切除的喉鳞状细胞癌组织及30例癌旁组织中Maspin、Ets1的表达。 结果 Maspin、Ets1在喉鳞状细胞癌组织中和癌旁组织中的阳性表达率差异有统计学意义(P<0.05);Maspin的阳性表达率与肿瘤直径、组织学分级、TNM分期及增殖活性Ki-67相关(P<0.05);Ets1的阳性表达率与组织学分级、TNM分期、淋巴结转移及增殖活性Ki-67相关(P<0.05)。Maspin、Ets1在喉鳞状细胞癌组织中的表达呈负相关性(P<0.01)。 结论 Maspin、Ets1共同参与了喉鳞状细胞癌的发生、发展,其表达反映了喉鳞状细胞癌的恶性程度,有利于进一步阐述喉鳞状细胞癌演变的相关机制。

关键词: 喉鳞状细胞癌, Ets1, 免疫组织化学, Maspin

Abstract: Objective To investigate the significance of Maspin, an anti-oncogene, and the transcription factor Ets1 in laryngeal squamous carcinoma. Methods The expression of Maspin and Ets1 was evaluated in 70 samples of laryngeal squamous carcinoma and 30 samples of non-cancerous adjacent tissues by immunohistochemistry(EnVisionTM, Fuzhou Mai Xin Biological Ltd. Co., China). Results The difference in the positive rates of expression of Maspin and Ets1 between the laryngeal squamous carcinoma and adjacent samples was statistically significant(P<0.05)Positive expression of Maspin was associated with tumor size, histological classification, TNM staging, and Ki-67 expression(P<0.05). Additionally, positive expression of Ets1 was associated with histological classification, TNM staging, lymph node metastasis, and Ki-67 expression(P<0.05). However, there was negative correlation between the expression of Maspin and Ets1 in laryngeal squamous carcinoma. Conclusion Maspin and Ets1 are involved in the progression of laryngeal squamous carcinoma; their expression not only reflects the malignant degree of laryngeal squamous carcinoma, but also is helpful in further expounding related mechanisms in the development of laryngeal squamous carcinoma.

Key words: Ets1, Immunohistochemistry, Maspin, Laryngeal squamous carcinoma

中图分类号: 

  • R739.65
[1] 黄选兆,汪吉宝. 实用耳鼻咽喉科学[M]. 北京: 人民卫生出版社, 2005: 502-506.
[2] 高鹏,王培戈,范晓琳, 等. Maspin和E-cadherin蛋白表达与胃癌临床病理学的关系[J].山东医药,2007,47(6):30-31.
[3] 齐淑轶, 蔡勇, 邓莅霏, 等. Maspin在非小细胞肺癌组织中的表达及意义[J]. 山东医药,2012, 52(3):9-11. QI Shuyi, CAI Yong, DENG Lifei, et al. Maspin expression and its clinical significance in non-small cell lung cancer[J]. Shandong Med J, 2012, 52(3):9-11.
[4] 杨伟萍, 韦长元, 周建华, 等. Maspin在65例乳腺癌中的表达及其临床意义[J]. 肿瘤学杂志,2010, 16(3):163-167. YANG Weiping, WEI Changyuan, ZHOU Jianhua, et al. Expression of Maspin in 65 Cases with Breast Cancer and its Significance[J]. J Oncol, 2010, 16(3):163-167.
[5] 杨娜, 安牧尔. Maspin和VEGF-C蛋白表达与卵巢癌发生及临床病理学的关系[J].疑难病杂志, 2012, 11(4):274-276. YANG Na, AN Muer. Expression of Maspin and VEGF-C protein in human ovarian carcinoma and its relationship with clinicopathological variables[J]. Chin J Diff Complicated Cases, 2012, 11(4):274-276.
[6] 邸丽双,王德华,高阳. Maspin和Caspase-3在宫颈癌中的表达及相关性[J]. 天津医科大学学报,2009, 15(1):77-80. DI Lishuang, WANG Dehua, GAO Yang. The expression and correlation of Maspin and Caspase-3 in cervical carcinoma[J]. J Tianjin Med Univ, 2009, 15(1):77-80.
[7] 吴齐斌, 宋一一, 孙蓬明. Maspin基因在妇科恶性肿瘤中的研究进展[J]. 海峡预防医学杂志,2012, 18(1):25-27.
[8] Odero-Marah VA, Khalkhali-Ellis Z, Chunthapong J, et al. Maspin regulates different signaling pathways for motility an adhesion in aggressive breast cancer cells[J]. Cancer Biol Ther, 2003, 2(4):398-403.
[9] Shi HY, Zhang W, Liang R, et al. Modelinghuman breast cancer metastasis in mice:maspin as a paradigm[J]. Histol Histopathol, 2003, 18(1):201-206.
[10] 马瑛. Maspin在肿瘤中的研究进展[J].中国现代药物应用,2015, 9(22):250-251.
[11] Song SH, Park HM, Eom DW, et al. The expression of p16(INK4a)and Ki-67 in relation to high-risk human papilloma viral load and residual disease after conization with positive margins[J]. Int J Gynecol Cancer, 2007, 17(4):858-867.
[12] Oikawa T. ETS transcription factors: possible targets for cancer therapy[J]. Cancer Sci, 2004, 95(8):626-633.
[13] 于湧,张一楚. Ets家族转录因子及其与肿瘤浸润转移的关系[J]. 国外医学肿瘤学分册, 2003, 30(3):177-179. YU Yong, ZHANG Yichu. Ets family of transcription factors and its relationship with tumor infiltration and metastasis[J]. Foreign Med Sci(Cancer Section), 2003, 30(3):177-179.
[14] 王新允,孙翠云,郑海燕,等. 肺癌中Etsl mRNA和c-Met蛋白表达细胞芯片的研究[J]. 国际呼吸杂志,2008, 28(1):1-3.
[15] 任涛文,周永宁,吴静. 等. 胃癌组织中Ets-1的表达及其与血管生成临床病理特征和预后的关系[J]. 中华肿瘤杂志,2009, 31(9):674-677. REN Taowen, ZHOU Yongning, WU Jing, et al. Relationship between Ets-1 expression and angiogenesis,clinicopathological features and survival of patients with gastric carcinoma[J]. Chin J Oncol, 2009, 31(9):674-677.
[16] 何常, 陈佳, 钟愉,等. 结直肠癌内Ets-1、血管内生长因子C蛋白及微血管和微淋巴管密度的意义[J].中华病理学杂志, 2007, 36(5):331-332.
[17] 郑丽娟, 卢启明. Ets-1和E-cadherin 在食管鳞状细胞癌中的表达及临床意义[J].中华消化内镜杂志,2010,27(4):204-205.
[18] Pap Z, Pavai Z, Denes L, et al. An immunohistochemical study of colon adenomas and carcinomas:E-cadherin, Syndecan-1, Ets-1[J]. Pathol Oncol Res, 2009, 15(4):579-587.
[19] Zhang M, Volpert O, Shi YH, et al. Maspin is anangiogenesis inhibitor[J]. Nat Med, 2000, 6(2):196-199.
[20] 周立莉,葛新国,蔡茂怀,等. 非小细胞肺癌中ETS-1与E-cadherin、N-cadherin、Vimentin表达相关性的研究[J].癌症进展,2015, 13(5):504-511. ZHOU Lili, GE Xinguo, CAI Maohuai, et al. The correlation between expression of ETS-1 and E-cadherin, N-cadherin and Vimentin in non-small cell lung cancer[J]. Oncol Prog, 2015, 13(5):504-511.
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