鼻呼出气一氧化氮的检测及临床应用

doi:10.6040/j.issn.1673-3770.1.2019.026

摘要/Abstract

摘要：

一氧化氮（NO）是L-精氨酸被一氧化氮合成酶催化后所生成的产物，是气道炎症的标志物之一。鼻部NO（nNO）可构成鼻腔的防御屏障，保持鼻窦的相对无菌。临床上最常用的nNO检测方法是利用鼻塞式探头置于前鼻孔直接采集鼻呼出气。目前nNO已用于囊性纤维化及原发性纤毛运动障碍的筛查诊断，由于nNO与鼻窦窦口的阻塞程度等多种因素相关，动态监测治疗前后的nNO值及联合口呼出气一氧化氮（FeNO）检查对早期发现上下气道嗜酸粒细胞性炎症更有临床应用价值。

关键词: 一氧化氮, 鼻部一氧化氮, 呼出气一氧化氮, 检测, 临床应用

Abstract:

Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO）examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable.

Key words: Nitric oxide, Nasal nitric oxide, Frictional exhaled nitric oxide, Detection, Clinical application

中图分类号:

R765

陈芝文,程雷. 鼻呼出气一氧化氮的检测及临床应用[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 124-128.

Zhiwen CHEN,Lei CHENG. Detection and clinical application of nasal nitric oxide[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 124-128.

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