山东大学耳鼻喉眼学报 ›› 2026, Vol. 40 ›› Issue (6): 125-132.

• 综述 • 上一篇    

视盘旁高反射卵圆形团块样结构的多模态影像特征、相关疾病谱与临床意义

张俊臣1,李鹏伟2,李志刚2   

  1. 濮阳市眼科医院)眼底内科, 河南 濮阳 457000 ;
    2. 黄河三门峡医院 眼科, 河南 三门峡 472000
  • 发布日期:2026-11-03
  • 通讯作者: 李鹏伟. E-mail:1354972836@qq.com

Peripapillary hyperreflective ovoid mass-like structures: multimodal imaging features, associated disease spectrum, and clinical significance

ZHANG Junchen1, LI Pengwei2, LI Zhigang2   

  1. 1. Department of Retinal Medicine, Puyang Second People's Hospital (Puyang Eye Hospital), Puyang 457000, Henan, China 2. Department of Ophthalmology, Huanghe Sanmenxia Hospital, Sanmenxia 472000, Henan, China
  • Published:2026-11-03

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摘要： 视盘旁高反射卵圆形团块样结构(peripapillary hyperreflective ovoid mass-like structures, PHOMS)是多模态影像技术发展催生的重要影像学标志物。本综述首次以轴浆淤滞为统一病理机制,系统阐释了PHOMS 的多模态影像学特征及演变规律,并明确其与各类视神经疾病及系统性疾病的广泛关联,此外还着重指出儿童与青少年群体中 PHOMS 的高检出率及其与视盘解剖形态的相关性。同时,本文还系统构建了 PHOMS 与视盘玻璃膜疣的鉴别诊断框架,明确了其在疾病活动性监测及预后评估中的潜在应用价值。值得注意的是,本综述总结了当前研究的争议与未解问题,展望了人工智能辅助量化分析等未来研究前沿,以期为 PHOMS 的临床解读与相关研究提供更为系统的理论框架与创新视角。

关键词: 视盘旁高反射卵圆形团块样结构, 光学相干断层扫描, 光学相干断层扫描血管成像, 轴浆淤滞, 视盘玻璃膜疣

Abstract: Objective Peripapillary hyperreflective ovoid mass-like structures(PHOMS)are an important imaging biomarker that has emerged with the advancement of multimodal imaging technologies. This review, for the first time, adopts axoplasmic stasis as a unifying pathological framework to systematically elucidate the multimodal imaging features and evolutionary rules of PHOMS, clarify their extensive association with various optic nerve and systemic diseases, and highlight the high detection rate of PHOMS in children and adolescents as well as its correlation with optic disc morphology. Meanwhile, this paper systematically establishes a differential diagnostic framework for distinguishing PHOMS from optic disc drusen and defines the potential application value of PHOMS in monitoring disease activity and evaluating prognosis. Notably, this review summarizes the current controversies and unresolved issues in the field and outlines future research frontiers, such as artificial intelligence-assisted quantitative analysis, aiming to provide a more systematic theoretical framework and innovative perspectives for the clinical interpretation of PHOMS and related research.

Key words: Peripapillary hyperreflective ovoid mass-like structures, Optical coherence tomography, Optical coherence tomography angiography, Axoplasmic stasis, Optic disc drusen

中图分类号: 

  • R774.2
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