关键词: 氯雷他定；治疗；生活质量, 变应性鼻炎；儿童；丙酸氟替卡松

Abstract:

Objective   To evaluate the therapeutic effect of fluticasone propionate and loratadine granules on quality of life(QOL) in patients with allergic rhinitis in childhood. Methods   77 patients with allergic rhinitis in childhood were randomly in this study. They were compared with self-controlled and healthcontrolled groups.QOL was measured by using rhinoconjunctivitis quality of life questionnaire(RQLQ). Patients were investigated 2 and 4 weeks after using fluticasone and Loratadine respectively. Symptoms were evaluated by the patients, and signs were evaluated by the investigators using scores under self-controlled models. RQLQ was administered at the start of treatment and 2 and 4 weeks after the treatment. Results   Fluticasone and loratadine improved the symptoms and signs. The 4-week scores which reached that of the health group were significantly less than the pre-treatment scores and the 2- week scores.  Conclusion   Fluticasone and loratadine play an extremely important role in the treatment and improve the QOL in patients with allergic rhinitis in childhood.

Key words: Childhood, Fluticasone propionate, Treatment； Quality of life, Loratadine granules, Allergic rhinitis