山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (3): 29-31.doi: 10.6040/j.issn.1673-3770.0.2015.389

• 论著 • 上一篇    下一篇

咽异物感伴有咽喉反流患者抗反流治疗的临床观察

周锋,王兴君,赵军,章少彬   

  1. 广州市第十二人民医院耳鼻咽喉头颈外科, 广东 广州 510620
  • 收稿日期:2015-09-11 出版日期:2016-06-16 发布日期:2016-06-16
  • 作者简介:周锋. E-mail:z63f@163.com

Clinical observation of anti-reflux treatment in patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux

ZHOU Feng, WANG Xingjun, ZHAO Jun, ZHANG Shaobin   

  1. Department of Otolaryngology &Head and Neck Surgery, The 12th Hospital of Guangzhou City, Guangzhou 510620, Guangdong, China
  • Received:2015-09-11 Online:2016-06-16 Published:2016-06-16

摘要: 目的 观察抗反流治疗对咽异物感伴有咽喉反流的临床疗效。 方法 将门诊以咽异物感自评超过3分,患病1个月以上的患者,进行反流症状指数量表(RSI)及反流临床表现量表(RFS)评分,对RSI超过13分及RFS超过7分的患者进行抗反流治疗,以能持续治疗8周以上为有效观察对象,共104例。分析入组患者反流各症状发生率、反流临床表现各体征发生率,并进行疗效评定。 结果 104例咽异物感患者多有反流症状清嗓动作(92/104,88.46%),主要反流体征为后连合肥厚(97/104,93.27%),红斑/充血(89/104,85.57%),喉内黏稠分泌物(87/104,83.65%),喉室阻塞(73/104,70.19%)等,经抗反流治疗,有效61例,有效率为58.65%;RSI治疗前后比较,差异有统计学意义(t=1.975,P<0.05);RFS治疗前后比较,差异无统计学意义(t=1.258,P>0.05)。 结论 咽异物感伴反流症状的患者,通过反流治疗是有效的。对于有咽异物感的患者,经过长期治疗效果不明显,应考虑是否有咽喉反流的可能。

关键词: 反流临床表现评分, 咽异物感, 反流症状指数, 咽喉反流

Abstract: Objective To observe the clinical efficacy of anti-refleux therapy in patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux. Methods A total of 104 patients were selected as study subjects, who had self-rating foreign-body sensation score>3 points, disease course≥1 months, and received continuous anti-reflux treatment for more than 8 weeks due to reflux symptom index(RSI)>13 points and reflux clinical presentation syndrome(RFS)>7 points after scoring. The rates of all reflux syndromes and signs of reflux clinical symptoms were analyzed, and clinical efficacy was evaluated. Results Of the 104 patients, most had reflux symptom hawking behavior(92/104,88.46%), with primary reflux signs being posterior commissurehypertrophy(97/104,93.27%), Erythema/congestion(89/104,85.57%), intra-throat sticky secretions(87/104,83.65%), ventriculuslaryngis obstruction(73/104,70.19%)and so on. After anti-reflux treatment, 61 were effective, with effective rate of 58.65%. Compared with treatment before, there was significant difference in RSI(t=1.975,P<0.05)but no significant difference was observed in RFS (t=1.258,P>0.05)after treatment. Conclusion Anti-reflux treatment is effective to patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux. As to patients with pharyngealforeign body sensation, laryngopharyngeal reflux should be considered if long-term treatment shows no significant efficacy.

Key words: Laryngopharyngeal reflux, Pharyngeal foreign body sensation, Reflux symptom index, Reflux clinical presentation syndrome

中图分类号: 

  • R766.1
[1] James B Snow Jr., P.AshleyWackym. Ballenger耳鼻咽喉头颈外科学[M].李大庆,译.北京:人民卫生出版社,2012:995.
[2] 刘慧茹, 陈广杰.咽异感症268例病因分析[J].蚌埠医学院学报, 2007, 32(1):70-71. LIU Huiru, CHEN Guangjie. Analysis of disease causes for 268 patients with pharyngealforeign body sensation[J]. J Bengbu Med Coll, 2007, 32(1):70-71.
[3] Cherry J, Margulies S I. Contact ulcer of the larynx[J].Laryngoscope,1968, 78(11):1973-1940.
[4] 郑宏良, 陈东辉.咽喉反流疾病的诊治亟待规范[J].中华耳鼻咽喉头颈外科杂志, 2013, 48(6):441- 444. ZHENG Hongliang, CHEN Donghui. The diagnosis and treatment of laryngopharyngeal refulxdisease urgent to be specified[J]. Chin J Otorhinolaryngol Head Neck Surg, 2013, 48(6):441- 444.
[5] Belafsky P C, Postma G N, Koufman J A.The validity and reli—ability of the reflux finding score(RFS)[J].Laryngoscope, 2001, 111(8):1313.
[6] Belafsky P C, Postma G N, Koufman J A.Validity and reliabil—ityofthe reflux symptom index(RSI)[J].J Voice, 2002, 16(2):274.
[7] 彭莉莉, 李进让, 张立红.三位不同职称喉科医师对咽喉反流体征评分量表的应用研究[J].中华耳鼻咽喉头颈外科杂志, 2013, 48(6):461- 464. PENG Lili, LI Jinrang, ZHANG Lihong. Study on consistency of reflux score evaluated by three different level of throat physicians[J]. Chin J Otorhinolaryngol Head Neck Surg, 2013, 48(6):461- 464.
[8] 李进让.咽喉反流性疾病的诊断和治疗[J].中华耳鼻咽喉头颈外科杂志, 2009, 44(2):172-176. LI Jinrang. Diagnosis and treatment of laryngopharyngeal refulxdisease[J]. Chin J Otorhinolaryngol Head Neck Surg, 2009, 44(2):172-176.
[9] Gupta R, Sataloff R T.Laryngopharyngeal reflux: current concepts and questions[J].Curr Opin Otolaryngol Head Neck Surg, 2009, 17(3):143-148.
[1] 吴玮,王磊,陈升,李连勇,王刚. 胃食管气道反流性疾病多学科研究及进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 1-14.
[2] 刘莲莲,李进让. 阻塞性睡眠呼吸暂停与咽喉反流[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 15-22.
[3] 张利,张梦茹,阿丽米热·艾尔肯,邱忠民. 咽喉反流性疾病在常见呼吸道疾病中的作用[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 23-29.
[4] 胡志伟,陈冬,杨栋,吴继敏. 胃食管气道反流性疾病的诊断和治疗:基于2020~2024年相关共识和指南[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 30-38.
[5] 赵佳宁,崔元馨,王丹,赵明. 咽喉反流与复发性呼吸道乳头状瘤病的关系及其机制探讨[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 39-45.
[6] 张杉,陈秋,周方伟,马亦飞. 生物标志物在咽喉反流性疾病中的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 46-54.
[7] 周诗侗,杨艳艳,杨玉成,方红雁. 胃蛋白酶与咽喉反流性疾病:从致病机制到咽喉鳞状细胞癌的潜在风险因素[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 55-60.
[8] 席晓宇,隋昕珂,陈升,李连勇,钟长青. 咽喉反流性疾病的内镜下治疗[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 61-65.
[9] 牛燕燕,顾伟,金晓峰,霍红,杨大海,崔婷婷,王剑. 声带白斑组织中胃蛋白酶的表达分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 66-70.
[10] 王磊,王刚,孙喆喆,刘红丹,韩浩伦,李保卫,张晓丽,吴玮. 咽喉反流与声带良性增生性病变、声带白斑、慢性咽喉炎相关性研究[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 71-77.
[11] 崔小缓,尹龙龙,张延平,蒋兴旺,李丽娜. 咽喉反流患者唾液菌群与反流症状相关性分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 78-84.
[12] 李逗,隋昕珂,杨小慢,郭红媛,王敏,钟长青,李连勇. 单纯咽喉反流患者食管下段黏膜细胞内镜及病理指标变化[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 85-90.
[13] 孙喆喆,王刚,王磊,李保卫,韩浩伦,刘红丹,张晓丽,吴玮. 咽喉反流性疾病不同体位反流模式的研究[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 91-95.
[14] 魏鑫,邢东升,翟振伟,阎艾慧,刘振宇,曹弘薇. 妊娠期女性咽喉反流症状指数调查及影响因素分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 96-102.
[15] 李逢将,魏婕,刘红丹,张丽,赵伟超,武娜娜,王磊,吴玮,王瑞娟. 老年肺炎患者胃食管反流病和咽喉反流性疾病25例[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 103-107.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!