突发性聋预后的相关因素分析及疗程选择

doi:10.6040/j.issn.1673-3770.0.2015.429

摘要/Abstract

摘要： 目的探讨突发性聋预后的相关因素及疗程选择。方法回顾性分析突发性聋患者185例(228耳)的临床资料,分别就性别、年龄、耳侧、伴随症状、听力曲线类型、发病至治疗时间、损伤频率平均听阈及疗程对总有效率的影响,筛选出相关因素后行多因素二元Logistic回归分析。结果 228耳中无效144耳,有效31耳,显效23耳,痊愈30耳,总有效率为36.8%。单因素分析显示,性别、年龄、听力曲线类型、发病至治疗时间、损伤频率平均听阈及疗程均与总有效率密切相关(P<0.05),而与耳侧及眩晕、耳鸣及耳闷等伴随症状无关(P>0.05)。多因素回归分析表明,性别、年龄、听力曲线类型、发病至治疗时间、疗程与总有效率有相关性(P<0.05),而听力损伤频率平均听阈与总有效率无关(P>0.05)。结论女性患者预后优于男性患者;随着年龄增大、发病至治疗时间的延长,总有效率呈下降趋势;低频下降型预后最好,平坦下降型、全聋型次之,高频下降型最差。早期治疗可提高临床疗效,而对第1疗程无效者,宜再继续治疗2个疗程。

关键词: 突发性聋, 预后, 疗程, 相关因素

Abstract: Objective To explore the relevant prognostic factors of sudden deafness and selection of course of treatment. Methods Theclinical data of 185 patients with sudden deafness(228 ears)treated in the Affiliated Hospital of Qingdao University were retrospectively analyzed. The influence of gender, age, lesion sides, concurrent symptoms, audiogram types, duration between onset and treatment, pure tone average of injury frequency and course of treatment on overall response rate(ORR)was analyzed. After screening the relevant factors, multi-factor binary Logistic regression analysis was applied. Results Among 228 ears, 144 ears were non-effective, 31 ears were effective, 23 ears were markedly effective, and 30 ears were healed. ORR was 36.8%. Single factor analysis showed that gender, age, audiogram types, duration between onset and treatment, pure tone average of injury frequency and course of treatment were closely related to ORR(P<0.05), but not to lesion sides and concurrent symptoms, such as vertigo, tinnitus and ear fullness(P>0.05). Multi-factor regression analysis displayed that gender, age,audiogram types, duration between onset and treatmentand course of treatment all had a certain correlation with ORR(P<0.05), but the pure tone average of injury frequency was not correlated with ORR(P>0.05). Conclusion The prognosis of female patients is better than male patients. With age growing and duration between onset and treatment prolonging, the ORR has the decreased tendency. The prognosis oflow-frequencydescending type isthe best,followed by the flat-type andcompletely deafness type, and the high-frequencydescending type is the worst. Early treatment can improve the clinical efficacy of sudden deafness, and the patients who failin the first course of treatment shouldcontinue to be treated for two courses of treatment.

Key words: Relevant factors, Sudden deafness, Prognosis, Course of treatment

中图分类号:

R764.43

马荣峰,朱富高,孙美红,付涛,张晓恒,曹琳. 突发性聋预后的相关因素分析及疗程选择[J]. 山东大学耳鼻喉眼学报, 2016, 30(4): 69-74.

MA Rongfeng, ZHU Fugao, SUN Meihong, FU Tao, ZHANG Xiaoheng, CAO Lin. Analysis on the relevant prognostic factors of sudden deafness and selection of course of treatment.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 69-74.

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