Kimura病11例并文献复习

doi:10.6040/j.issn.1673-3770.0.2016.094

摘要/Abstract

摘要： 目的探讨Kimura病的临床症状、体征、相关病理学检查及实验室检测,并对其诊断、鉴别诊断及治疗的方法进行相关讨论总结。方法回顾性分析11例就诊于耳鼻咽喉头颈外科及皮肤科的Kimura病患者的临床相关资料,总结其实验室检查及病理检查的特点,同时对比分析经手术治疗及保守治疗后的疗效。结果 11例Kimura患者年龄平均39岁,均为男性,分别发生于耳前、耳后、颈部、颌下等部位,临床表现无显著特异性,常表现为病变区的无痛性渐近性肿胀,病理学表现为大量淋巴组织增生,有淋巴滤泡形成,并见有多量嗜酸性粒细胞浸润。实验室检查见外周血嗜酸性粒细胞升高,血清IgE升高。结论 Kimura病的诊断主要依据临床表现、实验室检查及病理检查。由于该病罕见、无特异性临床表现、病程长、慢性起病,易导致漏诊。对于耳鼻咽喉头颈外科医生来说,应具备相关知识储备,通过主诉、视诊、实验室检查及病理活检等给予早期诊断,避免误诊漏诊。Kimura病可通过手术切除或激素、放射治疗等多种方式相应控制肿物的扩散及复发。

关键词: Kimura病, 嗜酸性粒细胞, 血清IgE

Abstract: Objective To explorethe clinical signs,symptoms,pathological and laboratory examinations, diagnosis, differential diagnosis and treatmentof Kimuras disease. Methods Clinical data of 11 cases of Kimuras disease were retrospectively reviewed. The characteristics of laboratory and pathological examinations were summarized. The efficacies of surgical treatment and expectant treatmentwere compared. Results All patients were male, aged 39 years on theaverage.The location of the disease was preauricular, retroauricular, neck andsubmaxillay. Theclinical manifestations were painless progressive swelling. Pathologic characteristics were massivelymphadenosis, with the formation of lymphoid folliculars, and eosinophil infiltration. Laboratory examinationsshowed increased peripheral blood eosinophilia, and elevated serum IgE. Conclusion The diagnosis of Kimuras disease is mainly based on clinical manifestations, laboratory and pathological examinations. As the disease is rare, with no specific clinical manifestations, chronic onset, and duration long, misdiagnosis is likely to occur. Kimura disease through or Hormone therapy, radiotherapyand surgery can be adopted to treat this disease.

Key words: Serum IgE, Eosinophils, Kimuras disease

中图分类号:

R780.2

金成勋,赵雪,刘悦,魏宁,金春顺. Kimura病11例并文献复习[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 63-66.

JIN Chengxun, ZHAO Xue, LIU Yue, WEI Ning, JIN Chunshun. Report of 11 cases of Kimuras disease and review of literature.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 63-66.

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