山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (5): 50-53.doi: 10.6040/j.issn.1673-3770.0.2017.243

• 论著 • 上一篇    下一篇

耳鸣治疗仪联合银杏叶提取物注射液治疗突聋伴耳鸣的疗效分析

张玉波,岳丽艳,尹晓妍,吕哲,单春光   

  1. 河北医科大学第二医院耳鼻喉科, 河北 石家庄 050000
  • 收稿日期:2017-06-02 出版日期:2017-10-16 发布日期:2017-10-16
  • 通讯作者: 单春光. E-mail:shanchunguang@163.com

Effect of tinnitus treatment instrument combined with Ginkgo biloba extract on hearing and hemorheology in patients with sudden deafness and tinnitus.

ZHANG Yubo, YUE Liyan, YIN Xiaoyan, LÜ Zhe, SHAN Chunguang   

  1. Department of Otorhinolaryngology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
  • Received:2017-06-02 Online:2017-10-16 Published:2017-10-16

摘要: 目的 观察耳鸣治疗仪联合银杏叶提取物注射液对突聋伴耳鸣的疗效。 方法 选取108例突聋伴耳鸣患者,随机数表法分为观察组与对照组,各54例。对照组应用银杏叶提取物注射液治疗,观察组联合耳鸣治疗仪。比较两组患者的听力总有效率、耳鸣总有效率、治疗前后听阈值与血液流变学指标。 结果 两组患者听力总有效率比较,观察组(88.89%)高于对照组(66.67%);两组患者耳鸣总有效率比较,观察组(81.48%)高于对照组(61.11%)。治疗1周、2周、4周后,观察组的听阈值均低于对照组。治疗后观察组的全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度、红细胞聚集指数均低于对照组;治疗后观察组的红细胞变形指数高于对照组。 结论 耳鸣治疗仪联合银杏叶提取物注射液可有效改善突聋患者血液流变,缓解耳鸣症状,提高患者听力。

关键词: 突发性聋, 银杏叶提取物注射液, 耳鸣, 耳鸣治疗仪, 血液流变学

Abstract: Objective To observe the effect of a tinnitus treatment instrument combined with Ginkgo biloba extract injection on sudden deafness and tinnitus. Methods A total of 108 patients with sudden deafness and tinnitus were randomly divided into observation and control groups using the random number table, 54 assigned to each group. Control group was treated with ginkgo biloba extract injection, and observation group was additionally treated with tinnitus treatment instrument. The total effective rate of hearing, the total effective rate of tinnitus, the hearing threshold, and the hemorheology index before and after treatment were compared between the two groups. Results The total effective rate of hearing and the total effective rate of tinnitus after treatment in the observation group were 88.89% and 81.48% respectively, which were 66.67% and 61.11% in the control group. The auditory thresholds at 1 week, 2 weeks, and 4 weeks after treatment in the observation group were(48.67±5.20 )dB,(37.22±4.17 )dB, and(29.54±3.68)dB respectively, which were lower than those measured pre-treatment and those measured in the control group. The high shear viscosity, whole blood viscosity, whole blood low shear viscosity, plasma viscosity, and erythrocyte aggregation index in the observation group were lower than those measured pre-treatment and those measured in the control group, the red blood cell deformation index was higher than that of the pre-treatment and the control group. Conclusion Tinnitus treatment instrument combined with ginkgo biloba extract injection can effectively improve sudden deafness in patients with hemorheology, improve patient hearing, and provide relief from symptoms of tinnitus.

Key words: Ginkgo biloba extract injection, Hemorheology, Tinnitus, Tinnitus treatment instrument, Sudden deafness

中图分类号: 

  • R764.43
[1] 钱怡, 钟时勋, 胡国华, 等. 双侧突发性耳聋疗效的影响因素分析[J]. 现代生物医学进 展, 2014, 14(29): 5675-5679. QIAN Yi, ZHONG Shixun, HU Guohua, et al. Analysis of the influencing factors of therapeutic effect of sudden bilateral sensorineural hearing loss[J]. Prog Mod Biom, 2014, 14(29):5675-5679.
[2] 闫波. 突发性耳聋患者耳鸣状况的危险因素研究[J]. 安徽医药, 2014, 18(8):1496-1498. YAN Bo. Risk factors of tinnitus in patients with sudden deafness[J]. Anhui Med Pharm J, 2014, 18(8):1496-1498.
[3] 叶放蕾, 王乐, 陈蓓, 等. 耳鸣患者耳鸣的心理声学特征分析[J]. 听力学及言语疾病杂志, 2012, 20(4):339-341. YE Fanglei, WANG Le, CHEN Bei, et al. The characteristics of tinnitus psychoacoustic in 159 patient[J]. J Aud Speech Pathology, 2012, 20(4):339-341.
[4] 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性 聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志,2015,50(6):443-445. Editorial Board of Chinese Otorhinolaryngology Head and Neck Surgery, Department of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association [J]. Guideline of diagnosis and treatment of sudden deafness(2015)[J]. Chin J Otorhinolaryngol Head Neck Surg, 2015, 50(6):443-445.
[5] 王洪田, 李明, 刘蓬, 等. 耳鸣的诊断和治疗指南(建议案)[J]. 中华耳科学杂志, 2009, 7(3):185-186. WANG Hongtian, LI Ming, LIU Peng, et al. Guidelines for the diagnosis and management of tinnitus(a parliamentary proposal)[J]. Chin J Otol, 2009, 7(3):185-186.
[6] 王强, 童步升, 段茂利, 等. 局部和全身应用激素治疗突发性耳聋耳鸣近期疗效的比较[J]. 安徽医药, 2015, 19(4):753-755. WANG Qiang, TONG Busheng, DUAN Maoli, et al. To invastigate the recent efficacy of systemic compared with local steroid in the treatment of tinnitus in patients with sudden hearing loss[J]. Anhui Med Pharmac J, 2015, 19(4):753-755.
[7] Rumeau C, Frère J, Montaut-Verient B, et al. Quality of life and audiologic performance through the ability to phone of cochlear implant users[J]. Eur Arch Otorhinolaryngol, 2015, 272(12):3685-3692.
[8] Zenner HP, Delb W, Kröner-Herwig B, et al. On the interdisciplinary S3 guidelines for the treatment of chronic idiopathic tinnitus[J]. HNO, 2015, 63(6):419-427.
[9] 刘俊杰, 张克军, 高福秀, 等. 声频共振治疗仪治疗耳鸣疗效观察[J]. 听力学及言语疾病杂志, 2012, 20(4):381-382.
[10] 胡娅琴, 邹帆, 高明华, 等. 听尼特耳鸣综合诊断治疗仪的疗效分析[J]. 重庆医 学, 2014, 43(2): 165-166. HU Yaqin, ZOU Fan, GAO Minghua, et al. Analysis on curative effect of TinniTest tinnitus comprehensive diagnostic and therapeutic apparatus[J]. Chongqing Med, 2014, 43(2):165-166.
[11] 赵颖, 张勋. 耳鸣治疗仪联合银杏蜜环口服液对突发性耳聋伴耳鸣的疗效观察[J]. 中国医学装备, 2016, 13(2):89-90. ZHAO Ying, ZHANG Xun. Clinical observation on treatment of sudden sensorineural hearing loss with tinnitus with Ginkgo mihuan oral liquid combined with Tinnitus-curing instrument[J]. Chin Med Equip, 2016, 13(2):89-90.
[12] Tunkel DE, Bauer CA, Sun GH, et al. Clinical practice guideline: tinnitus[J]. Otolaryngol Head Neck Surg, 2014, 151(2 S):1-40.
[13] Ramakers GG, van Zon A, Stegeman I, et al. The effect of cochlear implantation on tinnitus patients with bilateral hearing loss: a systematic review[J]. Laryngoscope, 2015, 125(11):2584-2592.
[14] Han SS, Nam EC, Won JY, et al. Clonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba[J]. J Neurol Neurosurg Psychiatry, 2012, 83(8):821-827.
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