PM2.5与变应性鼻炎患者上气道阻力的相关性研究

doi:10.6040/j.issn.1673-3770.1.2018.031

摘要/Abstract

摘要： 目的探讨变应性鼻炎(AR)患者上气道阻力与其周边环境PM_2.5浓度的关系。方法随机选取60例在临床上确诊为AR的患者行鼻声反射和鼻阻力测量,并连续监测其生活地区的PM_2.5浓度,使用SPSS 20.0统计软件,采用多元线性回归模型,对所纳入患者的鼻腔总阻力、鼻腔容积和鼻腔最小横截面积与空气污染暴露水平的关联进行分析。结果鼻声反射和鼻阻力测量结果显示,受试者鼻腔总阻力、鼻腔最小横截面积、鼻腔容积随着PM_2.5浓度的变化动态改变,差异具有统计学意义。结论 PM_2.5的浓度变化影响AR患者的上气道阻力,PM_2.5的浓度越大、暴露时间越长,AR患者的上气道阻力越大。

关键词: 变应性鼻炎, 细颗粒物, 上气道阻力, 鼻声反射, 鼻阻力测量

Abstract: Objective To investigate the relationship between upper airway resistance and the concentration of atmospheric particulate matter with diameter <2.5 micrometers(PM_2.5)in patients with allergic rhinitis(AR). Methods Sixty patients with clinically diagnosed AR were randomly selected for nasal acoustic reflex and nasal resistance measurement. The PM_2.5 concentration in their living areas was continuously monitored. Using SPSS 20.0 statistical software, multiple linear regression models were used. The patient's total nasal resistance, nasal volume, and nasal minimum cross-sectional area were correlated with the air pollution exposure levels. The level of significance was set at P<0.05. Results Nasal acoustic reflex and nasal resistance measurements showed that the total nasal resistance, nasal minimum cross-sectional area, and nasal volume of the subject varied dynamically with varying PM_2.5 concentration, and the difference was statistically significant. Conclusion The concentration of PM_2.5 affects the upper airway resistance of patients with AR. The greater the concentration of PM_2.5 and longer the exposure time, the greater the upper airway resistance of patients with AR.

Key words: Allergic rhinitis, Fine particulate matter, Upper airway resistance, Nasal acoustic reflex, Nasal resistance measurement

中图分类号:

R765.2

金兴,胡大宇,朱丽,邓芙蓉,刘俊秀. PM_2.5与变应性鼻炎患者上气道阻力的相关性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 77-80.

JIN Xing, HU Dayu, ZHU Li, DENG Furong, LIU Junxiu. Correlation between PM_2.5 and upper airway resistance in patients with allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 77-80.

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