大气污染物对于变应性鼻炎症状严重度的影响

doi:10.6040/j.issn.1673-3770.1.2018.026

摘要/Abstract

摘要： 目的以柏树花粉过敏所致变应性鼻炎(AR)为研究对象,探讨大气污染物对变应性鼻炎严重程度的影响。方法招募柏树花粉AR患者81例,2016~2018年间每年在柏树花粉授粉期间记录患者每日鼻结膜炎症状评分,同时从中国气象局气象数据中心获取气象数据,从国家环境监测站数据库获取大气污染数据,应用多元线性回归分析探讨大气污染物浓度对于AR日均症状评分的影响。结果在控制柏树花粉浓度与气象因素影响的前提下,AR患者日均症状评分与大气中SO₂浓度有统计学意义的正相关,多元线性回归分析显示其相关系数=0.038, 95% CI (0.004, 0.072), P=0.027;而大气中PM_2.5, PM₁₀, CO, NO₂, O₃指标的浓度与AR日均症状评分均无统计学意义的关联。结论柏树花粉过敏性AR患者的症状严重度受到大气污染物的影响,SO₂浓度越高,AR症状越重。

关键词: 变应性鼻炎, 症状评分, 大气污染, 二氧化硫, 柏树花粉

Abstract: Objective The association between allergic disorder prevalence and monitored air pollutants has been supported by past research evidence. The aim of this study was to evaluate the effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen. Methods Eighty-one patients with allergic rhinitis(AR)caused by cypress pollen were recruited. From 2016 to 2018, patients recorded daily average symptom scores during the cypress pollen season. Meanwhile, the meteorological data were acquired from the Meteorological Data Center of the China Meteorological Administration, and air pollutant data were acquired from the database of the China National Environmental Monitoring Center. The effects of air pollutant concentrations on the daily average symptom scores of patients with AR were then analyzed using the multiple linear regression model. Results A statistical correlation between the concentration of SO₂ and daily average AR symptom score was found in this study(regression coefficient=0.038, 95% CI［0.004, 0.072］, P=0.027)after adjusting for the effects of cypress pollen concentration and meteorological variables, while the associations between average symptom score and other air pollutants including PM_2.5, PM₁₀, CO, NO₂, and O₃ were insignificant. Conclusion The severity of AR caused by cypress pollen is correlated with air pollutant concentrations, and SO₂ might significantly increase the severity of AR symptoms.

Key words: Allergic rhinitis, Symptom score, Air pollution, Sulfur dioxide, Cypress pollens

中图分类号:

R765

李丽莎,关凯,王子熹,崔乐. 大气污染物对于变应性鼻炎症状严重度的影响[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 81-87.

LI Lisha, GUAN Kai, WANG Zixi, CUI Le. The effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 81-87.

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