肿瘤转移抑制蛋白在舌鳞状细胞癌中的表达与临床意义

doi:10.6040/j.issn.1673-3770.0.2018.465

摘要/Abstract

摘要： 目的研究肿瘤转移抑制蛋白1(MTSS1)在舌鳞状细胞癌、癌旁正常组织中的表达及其意义。方法应用免疫组织化学方法检测舌鳞状细胞癌、癌旁正常组织中MTSS1蛋白的表达,并用单因素分析法研究其与临床病理因素的关系。结果 20例舌鳞状细胞癌组织中MTSS1的蛋白表达水平与20例配对癌旁正常组织相比,差异有统计学意义(P=0.005);34例转移组中MTSS1的蛋白表达水平与46例非转移组相比,差异有统计学意义(P =0.033);37例临床Ⅲ~Ⅳ期组中MTSS1的蛋白表达水平与43例临床Ⅰ~Ⅱ期组相比,差异有统计学意义(P<0.001)。结论 MTSS1蛋白在舌鳞状细胞癌的早期进展中发挥了重要作用,MTSS1蛋白表达水平的降低可能与舌鳞状细胞癌的浸润转移有关,可能抑制了TSCC的发生和发展。

关键词: 肿瘤转移抑制蛋白1, 舌鳞状细胞癌, 免疫组织化学, 转移, 蛋白表达

Abstract: Objective To compare the expression of metastasis suppressor 1(MTSS1)protein in tongue squamous cell carcinoma(TSCC)and normal tongue mucosa. Methods The expression of MTSS1 was analyzed in TSCC and normal tongue mucosa using immunohistochemical staining. Single-factor analysis was used to study the relationship between MTSS1 expression and clinicopathological factors. Results The expression of MTSS1 was lower in TSCC than in normal tongue mucosa(20 cases each). The expression of MTSS1 was higher in cases with positive lymph node metastasis(34 cases)than those negative for lymph node metastasis(46 cases). Furthermore, the expression of MTSS1 was higher in cases with higher clinical stage(37 cases)than in those with lower clinical stage(43 cases). Conclusion The decrease of MTSS1 expression may be associated with infiltration and metastasis of TSCC. MTSS1 may inhibit the occurrence and development of TSCC and play an important role in the early development of TSCC.

Key words: Metastasis suppressor 1, Tongue squamous cell carcinoma, Immunohistochemistry, Metastasis, Protein expression

中图分类号:

R766.49

蒋宁宁,王鹏来,袁长勇,黄晓峰,蒋常委,刘宗响,孙铁忠. 肿瘤转移抑制蛋白在舌鳞状细胞癌中的表达与临床意义[J]. 山东大学耳鼻喉眼学报, 2019, 33(6): 64-67.

JIANG Ningning, WANG Penglai, YUAN Changyong, HUANG Xiaofeng, JIANG Changwei, LIU Zongxiang,SUN Tiezhong. The expression and significance of metastasis suppressor 1 protein in tongue squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(6): 64-67.

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