Tim-3在变应性鼻炎中的作用及机制研究进展

doi:10.6040/j.issn.1673-3770.0.2019.582

摘要/Abstract

摘要： 变应性鼻炎(AR)是一种慢性非特异性鼻黏膜炎性病变,属于Ⅰ型变态反应,是一个全球性健康问题,可导致许多疾病和劳动力丧失,给社会带来的负担也越来越重。其发病过程中所包括的免疫细胞受到了不同的基因组的调控作用。现已有研究论证T细胞免疫球蛋白黏蛋白结构域分子-3(Tim-3)参与到免疫细胞的表达中,对很多免疫反应都有调节作用,与免疫系统疾病密切相关。目前针对变应性鼻炎的药物及治疗方法存在一定的局限性,因此找到更多有效的治疗方法刻不容缓。关于Tim-3在变应性鼻炎中的作用机制的相关研究很多,但其综述却是匮乏的,希望该文章,希望能丰富AR的免疫调控机制研究,并且为其治疗方法提供新的思路。

关键词: 变应性鼻炎, T细胞免疫球蛋白黏蛋白结构域分子-3, 发病机制, 综述

Abstract: Allergic rhinitis(AR)is a chronic, non-specific inflammatory disease of the nasal mucosa. As a Type I hypersensitivity reaction, it leads to several diseases and labor losses and is a global health problem that burdens society. Different proteins, including Tim-3, regulate the immune cells that are involved in the pathogenesis of AR. Tim-3 has been demonstrated to be involved in immune cell expression and has a regulatory effect on several immune responses. Thus, it is also closely related to disorders of the immune system. Presently, the treatment options and medications for AR are limited, and it require more effective therapeutic interventions. While there are several studies on Tim-3's mechanism of action in AR, a review of the available literature is lacking. This article aims to enrich the body of research on the immune regulation mechanism behind AR and provide new ideas for its treatment.

Key words: Allergic rhinitis, T cell immunoglobulin domain and mucin domain protein-3, Pathogenesis, Review

中图分类号:

R765

向浏岚,叶远航,蒋璐云,刘洋. Tim-3在变应性鼻炎中的作用及机制研究进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(6): 118-122.

XIANG Liulan, YE Yuanhang,JIANG Luyun, LIU Yang. Elucidating the role and mechanism of Tim-3 in allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 118-122.

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