ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (2): 151-158.doi: 10.6040/j.issn.1673-3770.0.2021.536
• 综述 • 上一篇
李孟婷,何书喜,王华
LI Mengting, HE Shuxi, WANG Hua
摘要： 圆锥角膜(KC)是一种进行性的角膜扩张性疾病,常常导致近视加重、散光增加。圆锥角膜的病理生理机制尚不完全清楚,除遗传因素外,近年来有很多关于KC和炎症性因素的研究。有研究表明在KC患者的泪液中发现有可检测水平的炎症因子与蛋白酶,其中发现KC患者泪液的白细胞介素-6、肿瘤坏死因子-α和基质金属蛋白酶-9水平升高,且升高的水平与KC的病程发展呈正相关。除此之外,一些外界因素可以通过某些行为间接导致炎症的加重,从而加速KC的发生发展,比如揉眼、过敏反应等。病理性揉眼会使角膜形态发生变化,同时改变角膜环境,导致角膜间接性损伤。过敏反应中的免疫球蛋白E则是KC的潜在炎症分子。论文从炎症因子的来源、导致KC的途径进行综述。
中图分类号:
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