JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression and significance of VEGF in nasal polyps

GAO Ying1，PAN Xin-liang2，WANG Yan1，LIU Ping-yun1   

  1. 1. Department of Otolaryngology, General Hospital of Jinan Iron and Steel Group Corporation, Jinan 250101, China;2. Department of Otolarynglogy & Head and Neck Surgery, Qilu Hospital of Shandong University, Jinan 250012
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-04-24 Published:2008-04-24
  • Contact: GAO Ying

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Abstract: To evaluate the role of vascular endothelial growth factor (VEGF) in the pathophysiology of nasal polyps. MethodsForty patients with nasal polyps were divided into two groups: group A (representing type 2 phase 1-2) and group B (representing type 2 phase 3 and type 3). Also 20 normal inferior turbinate tissues served as the control. The expression of VEGF in three groups was determined by an immunohistochemical method. ResultsThe expression of VEGF was weak in normal nasal mucous but strong in nasal polyps. The expression rate of VEGF in groups A and B was significantly higher than that in the control group, furthermore it was higher in group B than in group A. VEGF is mainly located in the inflammatory cells and epithelial cells surrounding the basilar membrane and inflammatory cells and endothelial cells surrounding the vessels. ConclusionOverexpression of VEGF in nasal polyps may contribute to growth of vessels and accumulation of inflammatory cells, and as a result, enhances development of nasal polyps.

Key words: Vascular endothelial growth factor, Immunohistochemistry , Nasal polyps

CLC Number: 

  • R765.21
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